2024
The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova
Chitwood M, Colijn C, Yang C, Crudu V, Ciobanu N, Codreanu A, Kim J, Rancu I, Rhee K, Cohen T, Sobkowiak B. The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova. Nature Communications 2024, 15: 2962. PMID: 38580642, PMCID: PMC10997638, DOI: 10.1038/s41467-024-47282-9.Peer-Reviewed Original ResearchConceptsMDR M. tuberculosisGenome sequenceResistance-conferring mutationsBeijing sublineageMDR strainsReproductive fitnessBeijing strainsCulture-positive casesLineagesMtb strainsMultidrug-resistant tuberculosisMDRMtbStrainMDR-TBMutationsResistant tuberculosisMDR-MTBSubstantial riskSublineagesTuberculosisSequence
2015
Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study
Salvatore PP, Becerra MC, Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T. Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. The Journal Of Infectious Diseases 2015, 213: 149-155. PMID: 26092854, PMCID: PMC4676541, DOI: 10.1093/infdis/jiv347.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsCase-control studyKatG Ser315Thr mutationMDR strainsMultiple case householdsResistance mutationsDrug resistance-associated mutationsMycobacterium tuberculosisMultidrug-resistant Mycobacterium tuberculosisSecondary household casesSer315Thr mutationMDR M. tuberculosisMultidrug-resistant tuberculosisMDR Mycobacterium tuberculosisResistance-associated polymorphismsLong-term prevalenceResistance-associated mutationsVivo fitness costsCase-control designEpidemiologic studiesHousehold casesTuberculosisExperimental modelM. tuberculosisMutations
2004
Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness
Cohen T, Murray M. Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness. Nature Medicine 2004, 10: 1117-1121. PMID: 15378056, PMCID: PMC2652755, DOI: 10.1038/nm1110.Peer-Reviewed Original ResearchConceptsDrug-sensitive strainsMDR strainsMultidrug resistanceMultidrug-resistant M. tuberculosisM. tuberculosisMultidrug-resistant tuberculosisTuberculosis control effortsEmergence of resistanceTB controlFuture burdenMDR diseaseMDRTB strainsEpidemiological measuresTuberculosisMDRSmall subpopulationMDRTBControl programsBurdenSingle locus mutationsSequential acquisitionDisease