The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes
Falcone JD, Sohal H, Kyriakides T, Bellamkonda RV. The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes. Journal Of Neural Engineering 2019, 16: 046005. PMID: 31048574, DOI: 10.1088/1741-2552/ab1ef9.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBlood-Brain BarrierCerebral CortexElectrodes, ImplantedElectrophysiological PhenomenaHistological TechniquesMaleMicroelectrodesRatsRats, Sprague-DawleyConceptsCCL2/CCR2 pathwayCCR2 pathwayBlood-brain barrier integrityIntracortical electrodesPro-inflammatory monocytesBlood-brain barrierBBB breachFunctional electrophysiologyChronic outcomesHistological outcomesWeek cohortCCR2 antagonistHistological effectsTreatment groupsElectrode implantationNeurodegenerative modelsBarrier integrityElectrophysiological recordingsNumber of neuronsWeeksHistologyLong-term recordingsBiological mechanismsNeural populationsElectrophysiology