2021
A Multicenter, Real World Analysis of Primary Central Nervous System Lymphoma in Those with and without Human Immunodeficiency Virus
Dittus C, Grover N, Sethi T, Cohen J, Voloschin A, Rabadey J, Tan X, Beaven A, Park S. A Multicenter, Real World Analysis of Primary Central Nervous System Lymphoma in Those with and without Human Immunodeficiency Virus. Blood 2021, 138: 1457. DOI: 10.1182/blood-2021-145133.Peer-Reviewed Original ResearchPrimary CNS lymphomaWhole-brain radiation therapyHD-MTXNon-Hodgkin lymphomaReal-world survivalPCNSL groupMedian PFSAntiretroviral therapyWorse OSPerformance statusEntire cohortAstra ZenecaDiffuse large B-cell lymphoma histologyExact testPrimary central nervous system lymphomaAutologous stem cell transplantExtranodal non-Hodgkin lymphomaCentral nervous system lymphomaLactose dehydrogenaseSignificant differencesCentral nervous system tumorsSeattle GeneticsAdvisory CommitteeDeep structure involvementHD-MTX treatmentImpact of Molecular Features of Diffuse Large B-Cell Lymphoma on Treatment Outcomes with Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy
Hill B, Roth C, Kositsky R, Dave T, Love C, McKinney M, Galal A, Neff J, Mian A, Kendall E, Ondrejka S, Chiaramonte M, Bhagat G, Ofori K, Reshef R, Kovach A, Sethi T, Mason E, Bhaskar S, Oluwole O, Pallas C, Ghosh N, Ferdman R, Chen G, Hernandez-Ilizaliturri F, Zurko J, Cunningham A, Shah N, Hu B, Stephens D, Ghosh M, Bailey N, Patel K, Pagel J, Kannan K, Hsi E, Vaidya R, Ip A, Goy A, Kambhampati S, Ohgami R, Andreadis C, Thacker E, Rozzi C, Parker C, Happ L, Dave S. Impact of Molecular Features of Diffuse Large B-Cell Lymphoma on Treatment Outcomes with Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy. Blood 2021, 138: 165. DOI: 10.1182/blood-2021-145764.Peer-Reviewed Original ResearchCAR T-cell therapyDiffuse large B-cell lymphomaChimeric antigen receptor T-cell therapyLarge B-cell lymphomaT-cell therapyCAR-T therapyB-cell lymphomaInferior PFSR diseaseBristol-Meyers SquibbCurrent equity holderADC therapeuticsCell therapySpeakers bureauBristol-Myers SquibbKite PharmaDLBCL patientsTreatment outcomesAnti-CD19 chimeric antigen receptor (CAR) T-cell therapyCD19 chimeric antigen receptor (CAR) T-cell therapyIntroduction Diffuse large B-cell lymphomaPre-treatment tumor biopsiesRelapsed/refractory (R/R) diseaseCAR T-cell infusionAdvisory CommitteeNo Difference in Survival Among Black Patients with Mycosis Fungoides and Sézary Syndrome: A Multicenter Retrospective Analysis
Allen P, Goyal S, Greenwell I, Scribner J, Rangarajan S, Mehta A, O'Leary C, Niyogusaba T, Huen A, Switchenko J, Tarabadkar E, Ayers A, Krishnasamy S, Porcu P, Sethi T, Iyer S, Lechowicz M. No Difference in Survival Among Black Patients with Mycosis Fungoides and Sézary Syndrome: A Multicenter Retrospective Analysis. Blood 2021, 138: 2441. DOI: 10.1182/blood-2021-151911.Peer-Reviewed Original ResearchMF/SSWhite blood cell countB patientsNB patientsMedian survivalSézary syndromeInferior survivalSystemic therapyMycosis fungoidesBlack patientsInsurance statusSeattle GeneticsExact testMultivariate Cox proportional hazards modelT-cell receptor clonalityHigh rateCox proportional hazards modelAdvisory CommitteeHigher nodal stageLarge registry studyHigh-risk featuresMulticenter retrospective analysisNumber of comorbiditiesYear of diagnosisKaplan-Meier curves
2016
Correlation of Toll-like Receptor (TLR) and PD-1 Pathways in Central Nervous System Lymphoma: A Clinicopathological Study on Outcomes
Sethi T, Kovach A, Rubinstein S, Lee L, Wang Y, Morgan D, Greer J, Vnencak-Jones C, Reddy N. Correlation of Toll-like Receptor (TLR) and PD-1 Pathways in Central Nervous System Lymphoma: A Clinicopathological Study on Outcomes. Blood 2016, 128: 929. DOI: 10.1182/blood.v128.22.929.929.Peer-Reviewed Original ResearchCentral nervous system lymphomaPD-1/PD-L1 expressionProgression-free survivalPD-L1 expressionToll-like receptorsPD-1/PD-L1Diffuse large B-cell lymphomaPD-1/ PDNervous system lymphomaPD-L1Overall survivalMYD88 mutationsPD-1System lymphomaStimulation of TLRsCancer cell survivalHigh-dose methotrexate-based therapySystemic diffuse large B-cell lymphomaCo-expressing PD-1Median progression-free survivalPrior solid organ transplantMyeloid differentiation primary response protein 88Adaptor proteinAdvisory CommitteeB-cell receptor pathway