2018
Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects
Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause The Journal Of The North American Menopause Society 2018, 25: 1201-1207. PMID: 30358714, DOI: 10.1097/gme.0000000000001219.Peer-Reviewed Original ResearchConceptsCoronary arteryEstrogen receptor immunoreactivityAmount of atherosclerosisHuman placental estrogen synthetaseHuman subjectsSmooth muscle cellsPrecursor androgensReceptor immunoreactivityCardioprotective effectsCoronary circulationEstrogen formationEstrogen receptorArteryCardiovascular systemER αMuscle cellsEndothelial cellsEstrogenEstrogen synthetaseMonkeysFirst evidenceSubjectsCellsAtherosclerosisLocal regulation
2017
Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum
Zsarnovszky A, Kiss D, Jocsak G, Nemeth G, Toth I, Horvath TL. Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum. Frontiers In Neuroendocrinology 2017, 48: 23-36. PMID: 28987779, DOI: 10.1016/j.yfrne.2017.10.001.Peer-Reviewed Original ResearchConceptsEffects of phytoestrogensThyroid hormonesBrain functionNormal physiological settingsMetabolic parametersMature brainEstrogen receptor interactionSteroid hormonesBrain developmentHormoneHomeostatic parametersIntercellular actionsHormonal mechanismsReceptor interactionNatural ligandEnergy metabolismCerebellumEndocrine disruptorsPhytoestrogensPivotal rolePhysiological settingsMetabolismGliaEstrogenNeurons
2015
Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats
Toth I, Kiss DS, Jocsak G, Somogyi V, Toronyi E, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. PLOS ONE 2015, 10: e0137462. PMID: 26339901, PMCID: PMC4560379, DOI: 10.1371/journal.pone.0137462.Peer-Reviewed Original ResearchConceptsAd libitum fed animalsFemale ratsRight-sided dominanceSatiety stateFed animalsOvariectomized female ratsContribution of estrogenMetabolic differencesHours of fastingIntensity of cellsState 3 mitochondrial respirationHypothalamic functionMetabolic asymmetryTissue metabolismHypothalamusEstrogenProportion of animalsHypothalamic asymmetryRatsAd libitumLateralizationHigher centersMitochondrial respiration rateEnergy metabolism
2012
A marriage made to last in drug design
Dietrich MO, Horvath TL. A marriage made to last in drug design. Nature Medicine 2012, 18: 1737-1738. PMID: 23223057, DOI: 10.1038/nm.3018.Peer-Reviewed Original Research
2009
Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge
Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge. Endocrinology 2009, 150: 2783-2790. PMID: 19282389, DOI: 10.1210/en.2008-0927.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstradiolEstrogensEstrous CycleFemaleGonadotropinsMiceMice, Inbred C57BLMidline Thalamic NucleiModels, AnimalNeural Cell Adhesion Molecule L1Neural Cell Adhesion MoleculesNeuronal PlasticityProtein IsoformsProtein Processing, Post-TranslationalRNA, MessengerSialic AcidsSialyltransferasesSynapsesConceptsNeural cell adhesion moleculePeriventricular areaIR-PSAPerineural spacePSA-NCAMCell adhesion moleculeAdhesion moleculesPSA-NCAM stainingExtent of stainingSialyltransferase mRNA levelsGonadotropin surgeNCAM stainingPreovulatory gonadotropinSynaptic plasticityProestrous afternoonEstrogenWestern blotProestrusIndividual neuronsRT-PCRMetestrusMRNA levelsHypothalamus tissueStainingSialyltransferase mRNA
2008
Cross-talk between estrogen and leptin signaling in the hypothalamus
Gao Q, Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus. AJP Endocrinology And Metabolism 2008, 294: e817-e826. PMID: 18334610, DOI: 10.1152/ajpendo.00733.2007.Peer-Reviewed Original ResearchConceptsAdipocyte-secreted hormone leptinGonadal steroid hormone estrogenAction of leptinMajor risk factorNeuroendocrine reproductive axisEnergy expenditureHalf of adultsSteroid hormone estrogenEnhanced food intakeFunction of estrogenEstrogen deficiencyRisk factorsHormone leptinCardiovascular diseaseHormone estrogenFood intakeBody fatReproductive axisLeptinEstrogenRegulation of reproductionEnergy homeostasisWeight gainEstrogen facilitatesNeuroendocrine processes
2007
Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge
Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge. Reproductive Sciences 2007, 14: 101-116. PMID: 17636222, DOI: 10.1177/1933719107301059.Peer-Reviewed Original ResearchConceptsGnRH secretionPituitary gonadotrophsGonadotrophin surgeSynaptic plasticityInsulinlike growth factor 1Triggering of ovulationOvarian estrogen secretionGrowth factor-1Neural cell adhesion moleculePituitary sensitizationGnRH cellsGnRH neuronsEstrogen secretionHypothalamic neuronsGonadal functionCell adhesion moleculeSex steroidsSpecific immunoneutralizationOvarian cycleGonadotrophsAdhesion moleculesEstrogenMaximal sensitizationSecretionFactor 1
2005
Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons
Abizaid A, Mezei G, Thanarajasingam G, Horvath TL. Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons. European Journal Of Neuroscience 2005, 21: 1536-1546. PMID: 15845081, DOI: 10.1111/j.1460-9568.2005.03964.x.Peer-Reviewed Original ResearchConceptsOvariectomized ratsRaphe nucleusDorsal raphe serotonergic neuronsEstradiol-treated ovariectomized ratsAbility of estradiolDouble-labeled cellsFos-immunoreactive cellsRaphe serotonergic neuronsMedian raphe nucleusFos-positive nucleiRaphe nuclei regionMidbrain rapheSerotonin immunocytochemistryOvarian functionSerotonergic neuronsEstrogen treatmentFos immunoreactivitySerotonergic systemFood intakeNeuronal responsesDirect projectionsPhotic stimulationEstradiolEstrogenNormal onset
2004
Presynaptic N‐methyl‐D‐aspartate receptor expression is increased by estrogen in an aromatase‐rich area of the songbird hippocampus
Saldanha CJ, Schlinger BA, Micevych PE, Horvath TL. Presynaptic N‐methyl‐D‐aspartate receptor expression is increased by estrogen in an aromatase‐rich area of the songbird hippocampus. The Journal Of Comparative Neurology 2004, 469: 522-534. PMID: 14755533, DOI: 10.1002/cne.11035.Peer-Reviewed Original ResearchConceptsHP neuronsVertebrate hippocampusSongbird hippocampusN-methyl-d-aspartate receptor expressionSubcellular characteristicsInfluence of estrogenFunctional plasticityType glutamate receptorsZebra finch brainPrecise mechanismSomal sizeExcitatory pathwaysReceptor expressionExcitatory neurotransmissionExcitatory synapsesGlutamate receptorsPostsynaptic locusPresynaptic boutonsHippocampusEstrogenKey interfacePlasticityNeuronsAromataseAutoreception
2000
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeurons
1999
Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat
Leranth C, Shanabrough M, Horvath T. Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat. Experimental Brain Research 1999, 128: 417-420. PMID: 10501815, DOI: 10.1007/s002210050863.Peer-Reviewed Original ResearchConceptsEstrogen receptorLong-term potentiationMedian rapheSupramammillary areaSubcortical structuresCalretinin-containing neuronsHippocampal long-term potentiationEffects of estrogenHippocampal electric activityCalretinin neuronsFemale ratsGonadal hormonesTheta rhythmRapheVibratome sectionsReceptorsNeuronsSerotoninElectric activityEstrogenRhythm regulationPotentiationLarge populationMemory processesCalretininEstrogen and microglia: A regulatory system that affects the brain
Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia‐Segura L, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Developmental Neurobiology 1999, 40: 484-496. PMID: 10453051, DOI: 10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsSex hormonesRat microglial cellsSecretion of cytokinesPresence of estrogenGlial cell typesMicroglial functionEstrogen actionMicroglial cellsGonadal steroidsGlial cellsSteroid actionNeuroendocrine eventsMicrogliaPresent review detailsGrowth factorEstrogenBrainPhysiological regulationHormoneCell typesReview detailsNew studiesRegulatory actionCellsRegulatory functionsAromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human Subjects
Diano S, Horvath T, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human Subjects. Menopause The Journal Of The North American Menopause Society 1999, 6: 21-28. PMID: 10100176, DOI: 10.1097/00042192-199906010-00006.Peer-Reviewed Original ResearchConceptsCoronary arteryEstrogen receptor immunoreactivityAmount of atherosclerosisHuman placental estrogen synthetaseHuman subjectsSmooth muscle cellsPrecursor androgensReceptor immunoreactivityCardioprotective effectsCoronary circulationEstrogen formationER alphaEstrogen receptorArteryCardiovascular systemMuscle cellsEndothelial cellsEstrogenEstrogen synthetaseAromataseMonkeysFirst evidenceSubjectsCellsAtherosclerosis
1998
Hormonal control of brain cells: Opposite effects of estrogen vs estrogen-progestin replacement on GnRH cell membrane composition in female monkey brains
HORVATH T, PARK M, GARCIASEGURA L, NAFTOLIN F. Hormonal control of brain cells: Opposite effects of estrogen vs estrogen-progestin replacement on GnRH cell membrane composition in female monkey brains. Reproductive Sciences 1998, 5: 95a-95a. DOI: 10.1016/s1071-5576(97)86303-4.Peer-Reviewed Original Research
1997
Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus
Horvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.Peer-Reviewed Original ResearchConceptsArcuate nucleusFemale ratsSynaptic plasticitySynaptic retractionMale ratsSynapse countsEstrogen-induced synaptic plasticityFemale arcuate nucleusVehicle-injected groupHypothalamic arcuate nucleusAdministration of estrogenAfternoon of proestrusQuantitative electron microscopic analysisOil-injected controlsGonadotropin secretionSynaptic reorganizationSynaptic countsConstant estrusEndogenous estrogensSynaptic remodelingSingle injectionTreatment groupsHormone injectionEstrogenOvarian cycleControl of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity
Horvath TL, Garcia-segura LM, Naftolin F. Control of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecological Endocrinology 1997, 11: 139-143. PMID: 9174856, DOI: 10.3109/09513599709152525.Peer-Reviewed Original ResearchConceptsSynaptic plasticityEstrogen-induced synaptic plasticityHypothalamic arcuate nucleusPreovulatory gonadotropin surgeInhibitory synaptic connectionsGonadotropin feedbackGonadotropin surgeArcuate nucleusPreovulatory surgePituitary gonadotrophsSynaptic connectionsSecretion resultsRecent evidenceMassive releaseEstrogenPossible roleGonadotropinHypothalamusCritical eventsGonadotrophs
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.
Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-80. PMID: 8940386, DOI: 10.1210/endo.137.12.8940386.Peer-Reviewed Original ResearchConceptsSynaptic retractionArcuate nucleusAxosomatic synapsesPreovulatory gonadotropinEstrous cycleMorning of metestrusPhysiological synaptic plasticitySurge of gonadotropinsMorning of estrusPreovulatory LH surgePreovulatory estradiolPreovulatory levelsLH surgeGonadotropin surgeHypothalamic mechanismsSynaptic remodelingEstrogen diethylstilbestrolSynaptic plasticityGonadotropinOvarian cycleControl femalesSynapsesPositive controlEstradiolEstrogenSynaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge
Naftolin F, Mor G, Horvath T, Luquin S, Fajer A, Kohen F, Garcia-Segura L. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-5580. DOI: 10.1210/en.137.12.5576.Peer-Reviewed Original ResearchPreovulatory gonadotropin surgeArcuate nucleusGonadotropin surgeSynaptic retractionMorning of metestrusEstrous cycleMorning of estrusAxosomatic synapsesPhysiological synaptic plasticitySurge of gonadotropinsPreovulatory estradiol surgePreovulatory LH surgeEstradiol surgeCirculating estradiolHypothalamic mechanismsPreovulatory levelsEstrogen diethylstilbestrolSynaptic plasticityLH surgeSynaptic remodelingGonadotropinEstrogenMidcycleMorphological eventsOvarian cyclePotential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity
Naftolin F, Leranth C, Horvath TL, Garcia-Segura LM. Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity. Cellular And Molecular Neurobiology 1996, 16: 213-223. PMID: 8743970, DOI: 10.1007/bf02088177.Peer-Reviewed Original ResearchConceptsSynaptic plasticityArcuate nucleusRole of GABAergicControl of LHMechanism of estrogenRat arcuate nucleusPotential neuronal mechanismsNeural cell adhesion moleculePOMC projectionsSynaptic retractionFSH secretionGnRH cellsGonadotropin levelsConstant estrusDevelopmental synaptogenesisEstrogen actionCell adhesion moleculeSynaptic inputsSynaptic patternsNeuronal mechanismsNeuronal membranesDevelopmental sex differencesAdhesion moleculesEstrogenAdult life
1995
Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins
Horvath T, Leedom L, Lewis C, Garcia-Segura L, Naftolin F. Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins. Current Opinion In Endocrinology Diabetes And Obesity 1995, 2: 186. DOI: 10.1097/00060793-199504000-00018.Peer-Reviewed Original ResearchSynaptic plasticityNumber of synapseRegulation of gonadotrophinBasal estrogen levelsUnderstanding of estrogenGonadotrophin controlSynaptic retractionEstrogen surgeGonadotrophin levelsEstrogen levelsPreovulatory riseArcuate nucleusGlial ensheathmentNeuronal perikaryaGlial cellsNeurotransmitter effectsEstrogenEstrogen inducesNegative feedback controlGonadotrophinPossible mechanismRetractionHypothalamusPerikaryaLevels