2023
Lead induced differences in bone properties in osteocalcin +/+ and −/− female mice
Yildirim G, Budell W, Berezovska O, Yagerman S, Maliath S, Mastrokostas P, Tommasini S, Dowd T. Lead induced differences in bone properties in osteocalcin +/+ and −/− female mice. Bone Reports 2023, 18: 101672. PMID: 37064000, PMCID: PMC10090701, DOI: 10.1016/j.bonr.2023.101672.Peer-Reviewed Original ResearchBone strengthMineral/matrixBone remodelingHigher blood lead levelsSerum turnover markersLow lead exposureMajor health problemBlood lead levelsRole of osteocalcinBV/TVBone mineral propertiesTurnover markersFracture riskFemale miceLead exposureHealth problemsEffects of leadLead levelsBone formationCollagen maturityCross-sectional areaOsteocalcinLead toxicityBone propertiesBiomechanical measurements
2019
High dose vitamin D supplementation does not rescue bone loss following Roux-en-Y gastric bypass in female rats
Niu A, Carpenter TO, Grams JM, Bozorgmehri S, Tommasini SM, Schafer AL, Canales BK. High dose vitamin D supplementation does not rescue bone loss following Roux-en-Y gastric bypass in female rats. Bone 2019, 127: 172-180. PMID: 31226531, PMCID: PMC6708762, DOI: 10.1016/j.bone.2019.06.015.Peer-Reviewed Original ResearchConceptsCalcium/creatinine ratioVitamin D supplementationSecondary hyperparathyroidismBone lossD supplementationGastric bypassGut hormonesRYGB groupParathyroid hormoneFracture riskFemale ratsUrine calcium/creatinine ratioBone volumeUrinary calcium/creatinine ratioHigh-dose vitamin D supplementationAdequate vitamin D supplementationC-terminal telopeptide (CTX) levelsHigher serum parathyroid hormoneIU vitamin D supplementationIU vitamin D/Bone phenotypeDose vitamin D supplementationResultant secondary hyperparathyroidismVitamin D/Serum parathyroid hormone
2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2005
Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*
Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*. Journal Of Bone And Mineral Research 2005, 20: 1372-1380. PMID: 16007335, DOI: 10.1359/jbmr.050326.Peer-Reviewed Original ResearchConceptsStress fracture riskYears of ageFracture riskBone sizeTissue-level mechanical propertiesStress fracturesNew prevention strategiesMale military recruitsBone morphologySlender bonesMedial-lateral widthNarrower tibiaeFracture incidenceBone quality parametersMales 17Tissue fragilityTibial diaphysisAnimal modelsBody weightPrevention strategiesBone qualityMilitary recruitsSection modulusCortical tissueMale athletes