2022
The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation
Higerd-Rusli G, Tyagi S, Liu S, Dib-Hajj F, Waxman S, Dib-Hajj S. The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation. Journal Of Biological Chemistry 2022, 299: 102816. PMID: 36539035, PMCID: PMC9843449, DOI: 10.1016/j.jbc.2022.102816.Peer-Reviewed Original ResearchConceptsMembrane proteinsIon channelsNeuronal functionDistinct neuronal compartmentsAxonal membrane proteinsRetrograde traffickingNeuronal polarityRecycling pathwayLate endosomesPlasma membraneSpecific proteinsAxonal traffickingNovel mechanismCell membraneSodium channel NaNeuronal compartmentsMultiple pathwaysLive neuronsVoltage-gated sodium channel NaProteinEndocytosisMembrane specializationsTraffickingMembraneChannel Na
1983
Regional node-like membrane specializations in non-myelinated axons of rat retinal nerve fiber layer
Hildebrand C, Waxman S. Regional node-like membrane specializations in non-myelinated axons of rat retinal nerve fiber layer. Brain Research 1983, 258: 23-32. PMID: 24010160, DOI: 10.1016/0006-8993(83)91222-2.Peer-Reviewed Original ResearchConceptsNerve fiber layerInitial axon segmentNon-myelinated axonsAxon segmentsGlial processesFiber layerRetinal nerve fiber layerMembrane specializationsRetinal ganglion cellsAdult rat retinaNodes of RanvierRat retinal nerve fiber layerOptic nerveGanglion cellsMuller cellsRat retinaAstrocytic processesAxonsAxon circumferenceLimited proportionCell processes