2016
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model
Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBiomarkersBrainDecision MakingDiffusion Tensor ImagingDisease Models, AnimalFemaleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMethylazoxymethanol AcetateMultimodal ImagingPrefrontal CortexRatsRats, Sprague-DawleyReversal LearningRewardSchizophreniaSchizophrenic PsychologyConceptsMAM ratsEarly schizophreniaReversal-learning taskEarly behavioral markersResting-state functional magnetic resonanceFunctional magnetic resonanceMethylazoxymethanol acetate (MAM) rat modelFunctional brain biomarkersPerceptual problemsBehavioral markersOrbitofrontal cortexLate adolescenceFunctional connectivityRat modelEarly diagnosisThree-choiceBehavioral studiesBehavioral symptomsPosterior corpus callosumSubstance abuseProdromal patientsSubthreshold symptomsVisual cortexBrain biomarkersSaline-treated controls
2013
Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013, 229: 527-538. PMID: 23748383, PMCID: PMC3770792, DOI: 10.1007/s00213-013-3159-9.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamine-Related DisordersAnimalsChlorocebus aethiopsCognitionDiscrimination, PsychologicalDose-Response Relationship, DrugInhibition, PsychologicalMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyPutamenReceptors, Dopamine D2Retention, PsychologyReversal LearningTime FactorsConceptsD2-like receptorsGray matterDrug usePositron emission tomography scanDopamine D2-like receptorsDrug-experienced individualsHuman methamphetamine usersRegimen of methamphetamineEmission tomography scanGray matter abnormalitiesMethamphetamine-induced increasesDrug-induced changesInhibitory controlNeurobiological risk factorsDopaminergic markersRisk factorsTomography scanDAT availabilityRight putamenTransporter availabilityPharmacological effectsStructural abnormalitiesRegimenMagnetic resonance imagesObjectivesThe purpose
2012
Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBehavior, AnimalBrainCentral Nervous System StimulantsChlorocebus aethiopsChoice BehaviorDiscrimination LearningDopamineDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugDrug Administration ScheduleFeedback, SensoryHomovanillic AcidMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyReceptors, Dopamine D2Retention, PsychologyReversal LearningSynaptic TransmissionTime FactorsConceptsInhibitory control deficitsIndividual differencesInhibitory controlStimulus-outcome associationsLike receptor availabilityReversal-learning performancePositive feedback sensitivityStimulant-dependent individualsSubstance abuse behaviorsDopamine transmissionDrug-induced neuroadaptationsControl deficitsSelective impairmentDrugs of abuseDopaminergic neurochemistryEscalating-dose regimenLike receptorsMethamphetamine exposureSubstance dependenceDopamine systemBrain dopamine levelsDopamine transporter availabilityDopaminergic neurotransmissionReceptor availabilityDeficits