2023
Trends and Outcomes in Cardiac Arrest Among Heart Failure Admissions
Chouairi F, Miller P, Loriaux D, Katz J, Sen S, Ahmad T, Fudim M. Trends and Outcomes in Cardiac Arrest Among Heart Failure Admissions. The American Journal Of Cardiology 2023, 194: 93-101. PMID: 36889986, DOI: 10.1016/j.amjcard.2023.01.012.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCardiac arrestHospital cardiac arrestHF admissionsHF hospitalizationArtery diseaseHeart failureRenal diseasePrimary HF admissionsHeart failure admissionsHigher inpatient mortalityClinical Modification codesLong-term outcomesNational Inpatient SampleMultivariate logistic regressionHF patientsInpatient mortalityMultivariate adjustmentInpatient SampleFemale genderTenth RevisionHigher oddsLower oddsInternational ClassificationSerious events
2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatients
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsEvaluation of Racial and Ethnic Disparities in Cardiac Transplantation
Chouairi F, Fuery M, Clark KA, Mullan CW, Stewart J, Caraballo C, Clarke J, Sen S, Guha A, Ibrahim NE, Cole RT, Holaday L, Anwer M, Geirsson A, Rogers JG, Velazquez EJ, Desai NR, Ahmad T, Miller PE. Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation. Journal Of The American Heart Association 2021, 10: e021067. PMID: 34431324, PMCID: PMC8649228, DOI: 10.1161/jaha.120.021067.Peer-Reviewed Original ResearchConceptsWhite patientsHispanic patientsBlack patientsCardiac transplantationHeart transplantationHigh riskEthnic disparitiesAdult heart recipientsAllocation system changePost-transplant deathPost-transplant mortalityOrgan Sharing databasePost-transplantation deathNew allocation systemHeart recipientsDiabetes mellitusRenal diseaseSharing databaseTransplantation ratesUnited NetworkContemporary outcomesPatientsTransplantationDonor characteristicsStudy periodElectrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival
Rehorn MR, Black-Maier E, Loungani R, Sen S, Sun AY, Friedman DJ, Koontz JI, Schroder JN, Milano CA, Khouri MG, Katz JN, Patel CB, Pokorney SD, Daubert JP, Piccini JP. Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival. Heart Rhythm 2021, 18: 1263-1271. PMID: 33839327, DOI: 10.1016/j.hrthm.2021.03.047.Peer-Reviewed Original ResearchConceptsHistory of VAsPerioperative mechanical circulatory supportAntiarrhythmic drug useMechanical circulatory supportVentricular arrhythmiasElectrical stormRisk factorsLVAD implantationCirculatory supportDrug useVentricular assist device implantationLeft ventricular assist deviceTime of LVADAssist device implantationObservational retrospective studyPopulation of patientsQuaternary care centerVentricular tachycardia ablationCox proportional hazardsDuke University HospitalVentricular assist deviceSympatholytic therapyMedical therapyCatheter ablationDevice implantationImpact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies
Chouairi F, Mullan CW, Sen S, Mori M, Fuery M, Elder RW, Lesse J, Norton K, Clark KA, Miller PE, Mulligan D, Formica R, Rogers JG, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T. Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies. PLOS ONE 2021, 16: e0247789. PMID: 33651802, PMCID: PMC7924739, DOI: 10.1371/journal.pone.0247789.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseAllocation system changeHeart allocation systemNew heart allocation policyNew heart allocation systemTransplantation of patientsOrgan Sharing databasePost-transplantation outcomesPost-transplant survivalTime of transplantationMechanical circulatory supportRate of transplantationNumber of patientsHeart allocation policyNew allocation systemStatus 1ACardiac transplantAdult patientsSharing databaseWaitlist survivalCirculatory supportClinical benefitCongenital cardiomyopathyUnited NetworkCHD patients
2020
Reducing ECG Artifact From Left Ventricular Assist Device Electromagnetic Interference
Loring Z, Sen S, Black-Maier E, Atwater BD, Russell SD, DeVore AD, Piccini JP. Reducing ECG Artifact From Left Ventricular Assist Device Electromagnetic Interference. Journal Of The American Heart Association 2020, 9: e017563. PMID: 32787630, PMCID: PMC7660795, DOI: 10.1161/jaha.120.017563.Peer-Reviewed Original ResearchConceptsHeartMate 3 LVADElectromagnetic interferenceRotational speedBandstop filterLow-pass filterHigh-frequency signal componentsImpeller rotationFrequency peakFast Fourier transformWaveform dataSignal componentsLeft ventricular assist deviceFourier transformFilterECG artifactsSignal peaksNoise artifactsDevicesSpeedVentricular assist devicePotential solutionsAssist deviceAdditional peaksInterferenceFrequency
2019
The application of appropriate use criteria for transthoracic echocardiography in a cardiac intensive care unit
Salik JR, Sen S, Picard MH, Weiner RB, Dudzinski DM. The application of appropriate use criteria for transthoracic echocardiography in a cardiac intensive care unit. Echocardiography 2019, 36: 631-638. PMID: 30969477, DOI: 10.1111/echo.14314.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitCurrent appropriate use criteriaAppropriate use criteriaIntensive care unitCare unitModern cardiac intensive care unitUse criteriaQuaternary care academic medical centerUnique clinical environmentAcademic medical centerTransthoracic echocardiographyCardiac arrestUnknown etiologyMedical CenterThird investigatorCardiac structureHealthcare resourcesAUC classificationClinical casesInitial evaluationTTEFurther studiesClinical environmentInvestigatorsIndications
2015
Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers: Potential Implications for the Choosing Wisely Campaign
Makarov DV, Soulos PR, Gold HT, Yu JB, Sen S, Ross JS, Gross CP. Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers: Potential Implications for the Choosing Wisely Campaign. JAMA Oncology 2015, 1: 185-194. PMID: 26181021, PMCID: PMC4707944, DOI: 10.1001/jamaoncol.2015.37.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsCatchment Area, HealthChi-Square DistributionDiagnostic ImagingFemaleGuideline AdherenceHumansLogistic ModelsMaleMedicareMultivariate AnalysisPractice Guidelines as TopicPractice Patterns, Physicians'Predictive Value of TestsProstatic NeoplasmsResidence CharacteristicsRetrospective StudiesRisk FactorsSEER ProgramUnited StatesUnnecessary ProceduresConceptsLow-risk prostate cancerProstate cancerBreast cancerProstate cancer imagingFourth quartileLow-risk breast cancerBreast cancer imagingLow-risk prostateEnd Results-MedicareRetrospective cohort studyMultivariable logistic regressionChoosing Wisely campaignPatient-level analysisAppropriateness of careHospital referral regionsCancer imagingQuality of careInappropriate imagingCohort studyWisely campaignHealth care spendingLowest quartileOdds ratioPatient levelHRR level
2008
Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc
Beckstein JC, Sen S, Schaer TP, Vresilovic EJ, Elliott DM. Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc. Spine 2008, 33: e166-e173. PMID: 18344845, DOI: 10.1097/brs.0b013e318166e001.Peer-Reviewed Original ResearchAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks
2006
Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments
Boxberger JI, Sen S, Yerramalli CS, Elliott DM. Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments. Journal Of Orthopaedic Research® 2006, 24: 1906-1915. PMID: 16865712, DOI: 10.1002/jor.20221.Peer-Reviewed Original Research