2009
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials 2009, 8: 986-992. PMID: 19855383, PMCID: PMC3415301, DOI: 10.1038/nmat2558.Peer-Reviewed Original ResearchConceptsMulti-scale structural hierarchyAnnulus fibrosus tissue engineeringTissue engineering applicationsLoad-bearing tissuesTensile responseEngineering applicationsTissue engineeringLaminatesBiomimetic materialsComplex mechanical functionsNative tissueStructural hierarchySuccessful engineeringEngineeringScaffoldsAnnulus fibrosusGreat interestShearingMechanical functionComplex tissuesDepositionMaterials
2008
Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction
Boxberger J, Auerbach J, Sen S, Dodge G, Elliott D. Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction. 2008, 127-128. DOI: 10.1115/sbc2008-192937.Peer-Reviewed Original ResearchWeeks post treatmentDisc degenerationPost treatmentIntervertebral disc degenerationRat lumbar discsLong-term effectsLumbar discVivo modelGAG lossDegenerationEarly lossHallmark featureTerm effectsGAG depletionMechanical functionDetectable changeGagGlycosaminoglycan contentSmall percentageTreatmentLow levelsMechanical changesHuman degenerationElevated stressHypermobilityEffect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension
Sen S, Boxberger J, Schroeder Y, Orias A, Elliott D. Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension. 2008, 609-610. DOI: 10.1115/sbc2008-193057.Peer-Reviewed Original ResearchDisc degenerationViscoelastic propertiesStructural finite element modelIntervertebral disc degenerationFinite element modelUniaxial tensile testsPhysiological cyclic loadingQuasi-static conditionsHuman AF tissueDynamic viscoelastic propertiesStatic viscoelastic propertiesAF tissueCyclic loadingElement modelTensile testsIntervertebral discMechanical assessmentRegenerative approachesTissueDegenerate tissueMechanical functionDegeneration
2007
Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs
Baker B, O’Connell G, Sen S, Nathan A, Elliott D, Mauck R. Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs. 2007, 1013-1014. DOI: 10.1115/sbc2007-176434.Peer-Reviewed Original ResearchFunctional tissue engineeringLength scalesLaminate structureCompressive loadingMultiple length scalesTensile deformationTensile propertiesCircumferential tensile propertiesTissue engineeringCentimeter length scalesFiber directionTransverse directionRadial tie fibersMechanical environmentKnee meniscusNanoscale interactionsAdjacent layersStructural propertiesCell patterningMechanical functionHorizontal axisAnnulus fibrosusMeniscusDeformationProperties