2024
Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study
Moreno-Gamazo N, Pries L, Marqués-Feixa L, Papiol S, Romero S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, van Os J, Rutten B, Fañanás L, Guloksuz S. Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study. Journal Of Affective Disorders 2024, 370: 118-123. PMID: 39488234, DOI: 10.1016/j.jad.2024.10.125.Peer-Reviewed Original ResearchChildhood traumaSuicidal ideationPsychiatric evaluation of patientsSCL-90-R.Environmental risk factorsGene-environment correlationHistory of CTSample of twinsTwin analysesGenetic vulnerabilityPsychiatric evaluationRisk factorsTwin studiesTwin pairsPhysical abuseEvaluation of patientsDizygotic twinsGenetic riskIdeationProtective factorsPsychosocial environmentIndividual characteristicsGenetic predispositionIncreased riskTotal CTThe association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociationYoung adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Young adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021. Epidemiology And Psychiatric Sciences 2024, 33: e48. PMID: 39390846, PMCID: PMC11561524, DOI: 10.1017/s2045796024000404.Peer-Reviewed Original ResearchConceptsMental healthcare expenditureMental healthcare costsHealthcare expendituresGeneral practitionersMental distressHealthcare costsPublic mental health approachYounger ageYoung adultsMental healthcare utilisationMental health approachPostal code levelYoung womenHealthcare utilisationOlder adultsSpecialist costsHealth approachMedical specialistsHealth insuranceMedical systemAge groupsTime pointsAdultsYoung peopleLinear regressionClassification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
Visoki E, Moore T, Zhang X, Tran K, Ly C, Gataviņš M, DiDomenico G, Brogan L, Fein J, Warrier V, Guloksuz S, Barzilay R. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry 2024, 81: 1020-1029. PMID: 39018056, PMCID: PMC11255979, DOI: 10.1001/jamapsychiatry.2024.1887.Peer-Reviewed Original ResearchMillennium Cohort StudyExposome scoreLifestyle factorsAdolescent Brain Cognitive DevelopmentCohort studyExposome-wide association studyAssociated with suicide attemptsUK Millennium Cohort StudyNational longitudinal cohortSuicide attemptsProtective exposuresLogistic regression modelsFamily history of suicideRisk classificationAdolescent Brain Cognitive Development StudyUS hospitalsEnvironmental/lifestyle factorsEmergency departmentTest associationsHistory of suicidePopulation settingCause of deathUS adolescentsFamily historyLongitudinal cohortF85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. F85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS. European Neuropsychopharmacology 2024, 87: 251. DOI: 10.1016/j.euroneuro.2024.08.496.Peer-Reviewed Original ResearchConcordant effect directionsLinkage disequilibrium score regressionGenome-wide association study dataCell adhesion molecule bindingGenetic architectureBrain measuresPolygenic scoresBrain phenotypesUnique genesGene OntologyBrain structuresConjunctional false discovery rateLinkage disequilibrium score regression analysisGenetic correlationsGenetic risk of schizophreniaComplex genetic architectureHeritable brain disorderKyoto Encyclopedia of GenesAssociated with schizophreniaInsignificant genetic correlationResting-state fMRIWhite matter integrityEncyclopedia of GenesPostsynaptic densityRisk of schizophreniaT78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK
Lin B, Pries L, Magnasco A, Gülöksüz S. T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK. European Neuropsychopharmacology 2024, 87: 195-196. DOI: 10.1016/j.euroneuro.2024.08.388.Peer-Reviewed Original ResearchExposome-wide association studyPolygenic risk scoresPRS-SCZGene-environment interactionsGene-environment interaction studiesPsychotic experiencesAssociation studiesPhysical health outcomesLogistic regression modelsNon-psychotic disordersHealth outcomesUK BiobankMental distressNominal significanceRisk scoreMedical conditionsSleep problemsSelf-harm behaviorsRegression modelsAdditive interactionGxE interactionsAgnostic analysisGxEGenetic underpinningsExposure to PECharacterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Malamud J, Guloksuz S, van Winkel R, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Rutten B, Huys Q. Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter. PLOS Computational Biology 2024, 20: e1012457. PMID: 39312537, PMCID: PMC11449358, DOI: 10.1371/journal.pcbi.1012457.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentEcological momentary assessment dataMood statesMood disordersDepressive stateMood dynamicsFeatures of mood disordersCombination of ecological momentary assessmentsControl of moodSymptoms of depressionInternal emotional statesAlterations to interactionsPsychopathological featuresMomentary assessmentMoodEmotional statesDepressionEnvironmental stimuliAssociations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences
Ku B, Yuan Q, Arias-Magnasco A, Lin B, Walker E, Druss B, Ren J, van Os J, Guloksuz S. Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences. Schizophrenia Bulletin 2024, sbae141. PMID: 39171674, DOI: 10.1093/schbul/sbae141.Peer-Reviewed Original ResearchPhysical activityPRS-SCZDistressing psychotic-like experiencesPsychotic-like experiencesDevelopment of psychosisMechanisms of physical activityGenetic liabilityParticipants of European ancestryPolygenic risk scoresIncome-to-needs ratioBody mass indexAssociated with trajectoriesAssociated with less riskAdolescent Brain Cognitive Development StudyAssociated with impaired functionFamily history of psychosisLinear mixed modelsGeneralized linear mixed modelsCognitive Development StudyHistory of psychosisEuropean ancestryGenetic riskFamily historyMass indexRisk scoreThe European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment
Schoretsanitis G, Correll C, Agorastos A, Sanchez A, Erzin G, Grigoras R, Benussi M, Gondek T, Guloksuz S, Højlund M, Jerotic S, Kilic O, Metaj E, Sidhu D, Skandali N, Skuhareuski A, Tveito M, Wolthusen R, Communication and Publications E, Chumakov E, de Filippis R. The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment. The World Journal Of Biological Psychiatry 2024, 25: 342-351. PMID: 38905131, DOI: 10.1080/15622975.2024.2367138.Peer-Reviewed Original ResearchConceptsEuropean Psychiatric AssociationAntipsychotic treatmentPsychiatrists' attitudesTherapeutic drug monitoringEarly-career psychiatristsExploratory factor analysisBenefit of therapeutic drug monitoringPsychiatric AssociationAntipsychoticsNegative expectationsAssociated with frequencyTDM useDrug monitoringTherapeutic drug monitoring useFactor analysisBeliefs of patientsHigh-income countriesLow-/middle-income countriesResponse varianceClinical benefitClozapineOutpatient settingLinear regression analysisClinical settingPsychiatrists401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank
Lin B, Pries L, Magnasco A, Guloksuz S. 401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank. Biological Psychiatry 2024, 95: s264. DOI: 10.1016/j.biopsych.2024.02.900.Peer-Reviewed Original ResearchThe relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.
Üçok A, Noyan H, Gülöksüz S, Saka M, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Şahin Cankurtaran E, Ulusoy Kaymak S, Rutten B, van Os J. The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study. Psychological Medicine 2024, 54: 2414-2425. PMID: 38606591, DOI: 10.1017/s0033291724000540.Peer-Reviewed Original ResearchNegative cognitive schemasChildhood traumaCognitive schemasPsychotic symptomsEU-GEIEmotional abuseBrief Core Schema ScalesEU-GEI studySubthreshold psychotic experiencesSubtypes of traumaChildhood emotional abuseChildhood Trauma QuestionnaireNon-clinical populationsHealthy controlsNegative schemasPositive symptomsPersecutory delusionsPsychotic experiencesSchema ScaleTrauma QuestionnaireChildhood abuseSymptom severitySchizophreniaSexual abuseAbuseThe why and the how of transdiagnostic clinical research in youth psychiatry
Díaz-Caneja C, Guloksuz S. The why and the how of transdiagnostic clinical research in youth psychiatry. European Neuropsychopharmacology 2024, 82: 55-56. PMID: 38490086, DOI: 10.1016/j.euroneuro.2024.02.012.Peer-Reviewed Original ResearchCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINEPopulation Salutogenesis—The Future of Psychiatry?
van Os J, Guloksuz S. Population Salutogenesis—The Future of Psychiatry? JAMA Psychiatry 2024, 81: 115-116. PMID: 38117509, DOI: 10.1001/jamapsychiatry.2023.4582.Peer-Reviewed Original ResearchDissecting causal relationships between cortical morphology and neuropsychiatric disorders
Goula A, Lin B, Li Y, Chang X, Grasby K, Medland S, Andreassen O, Rutten B, Guloksuz S, Van der Meer D, Luykx J. Dissecting causal relationships between cortical morphology and neuropsychiatric disorders. Neuroscience Applied 2024, 3: 103960. DOI: 10.1016/j.nsa.2024.103960.Peer-Reviewed Original Research
2023
“It has to be better, otherwise we will get stuck.” A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands
van Os J, Scheepers F, Milo M, Ockeloen G, Guloksuz S, Delespaul P. “It has to be better, otherwise we will get stuck.” A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands. Clinical Practice And Epidemiology In Mental Health 2023, 19: e17450179271206. PMID: 38680529, PMCID: PMC11046893, DOI: 10.2174/0117450179271206231114064736.Peer-Reviewed Original ResearchMental health careHealth careEnhance public mental healthDutch mental health care systemMental health care servicesMental health care systemIntegrated public health approachHigh-quality careMental health reformHealth care consumptionHealth care servicesPublic health approachHealth care systemMental health problemsSmall area indicatorsPublic mental healthSocial care organizationsPopulation-based approachGroup-based treatmentEcosystem of careRecovery CollegesEmpower patientsCare servicesHealthcare providersCare consumptionClustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation
van der Meer D, Cheng W, Rokicki J, Fernandez-Cabello S, Shadrin A, Smeland O, Ehrhart F, Gülöksüz S, Pries L, Lin B, Rutten B, van Os J, O’Donovan M, Richards A, Steen N, Djurovic S, Westlye L, Andreassen O, Kaufmann T, Aguilar E, Akdede B, Alptekin K, Altınyazar V, Amoretti S, Andric-Petrovic S, Arango C, Arrojo M, Atbaşoğlu C, Bernardo M, Binbay T, Bobes J, Cankurtaran E, Carracedo A, Cihan B, Delespaul P, García-Portilla M, González-Peñas J, Guloksuz S, Gümüş-Akay G, Jiménez-López E, Ulusoy Kaymak S, Kenis G, Lin B, López G, Luykx J, Maric N, Mezquida G, Mihaljevic M, Mirjanic T, Parellada M, Pries K, Rivero O, Rutten B, Saiz P, Can Saka M, Sanjuan J, Luis Santos J, Soygür H, Üçok A, Ulaş H, van Os J, Yalınçetin B, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, van Os J, Veling W. Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation. Schizophrenia Bulletin 2023, 50: 327-338. PMID: 37824720, PMCID: PMC10919784, DOI: 10.1093/schbul/sbad140.Peer-Reviewed Original ResearchAge-matched healthy controlsBrain maturational processesIndependent clinical cohortsOnset of symptomsPolygenic riskCortical tissue samplesGenetic risk factorsDevelopment of schizophreniaHeritable brain disorderSymptom onsetHealthy controlsRisk factorsClinical cohortEarly neurodevelopmentPolygenic risk scoresRisk scoreImmune systemSchizophrenia diagnosisBrain disordersSchizophreniaNeuronal communicationStrong associationEarly adulthoodTissue samplesMaturational processesComprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions
van der Horst M, Meijer Y, de Boer N, Guloksuz S, Hasan A, Siskind D, Wagner E, consortium C, Müderrisoğlu A, Privat A, Bouhuis A, Hasan A, Jongkind A, Gonzalez-Pinto A, Santacana A, D'Agostino A, Ertugrul A, Yağcioğlu A, Crespo-Facorro B, Sanchez-Barbero B, Spuch C, Morgenroth C, de Pinedo C, Casetta C, Bousman C, Pantelis C, Ovejas-Catalán C, Garcia-Rizo C, Okhuijsen-Pfeifer C, Cohen D, Ristic D, Beld E, Repo-Tiihonen E, Wagner E, Jeger-Land E, Vilella E, Bekema E, Sepúlveda S, Seghi F, Wiedenmann F, Martini F, Serio F, Vairano F, Mercuriali G, Boido G, Yoca G, van Beek H, Gijsman H, Tuppurainen H, Everall I, Novakovic I, Zorrilla I, Erdoğan I, Sapienza J, Bogers J, Tiihonen J, Vázquez-Bourgon J, van Os J, Schneider-Thoma J, Luykx J, Grootens K, Mar-Barrutia L, Martorell L, Bak M, Spangaro M, de Vos M, de Koning M, Garriga M, Lähteenvuo M, Bosia M, van der Horst M, Babaoğlu M, Veereschild M, Manchia M, Edlinger M, Fuentes-Pérez P, Paribello P, Lopez-Pena P, Kahn R, Cavallaro R, Veerman S, Gutwinski S, Schreiter S, Ripke S, Baltanás T, Oviedo-Salcedo T, Hallikainen T, Görlitz T, Alink W, Ayhan Y, Okhuijsen-Pfeifer C, Luykx J. Comprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions. Psychiatry Research 2023, 330: 115539. PMID: 37988817, DOI: 10.1016/j.psychres.2023.115539.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsClinical factorsDrug reactionsPrevalence ratesCommon adverse drug reactionsWeight gainSignificant weight gainMulti-center studyImproved treatment outcomesClozapine blood levelsClozapine monotherapyClozapine treatmentLower BMIBlood levelsTreatment outcomesHigh prevalencePrevalenceMean numberYounger participantsSex differencesParticipantsTreatmentComprehensive dissectionConstipationHypersalivationT15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental health