2024
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociationYoung adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Young adults, particularly young women, account for an increasingly large share of Dutch mental healthcare expenditure over the period between 2015 and 2021. Epidemiology And Psychiatric Sciences 2024, 33: e48. PMID: 39390846, PMCID: PMC11561524, DOI: 10.1017/s2045796024000404.Peer-Reviewed Original ResearchConceptsMental healthcare expenditureMental healthcare costsHealthcare expendituresGeneral practitionersMental distressHealthcare costsPublic mental health approachYounger ageYoung adultsMental healthcare utilisationMental health approachPostal code levelYoung womenHealthcare utilisationOlder adultsSpecialist costsHealth approachMedical specialistsHealth insuranceMedical systemAge groupsTime pointsAdultsYoung peopleLinear regression
2023
Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis
Ku B, Addington J, Bearden C, Cadenhead K, Cannon T, Compton M, Cornblatt B, Druss B, Gülöksüz S, Mathalon D, Perkins D, Tsuang M, Walker E, Woods S, Carrión R. Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 1437-1446. PMID: 37358832, PMCID: PMC10686327, DOI: 10.1093/schbul/sbad093.Peer-Reviewed Original ResearchConceptsClinical high riskHealthy comparisonsSocial functioningHigh riskPoor social functioningNorth American Prodrome Longitudinal StudyImportant risk factorRisk factorsPsychotic disordersEffective interventionsHealthy youthChildhoodLongitudinal studyAdulthoodPsychosisAssociationAdultsMaladaptationRiskSocial deficitsFurther researchFunctioningCommunity levelThe Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health
Smith W, Appelbaum P, Lebowitz M, Gülöksüz S, Calkins M, Kohler C, Gur R, Barzilay R. The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health. The Journal Of Pediatrics 2023, 263: 113583. PMID: 37353146, PMCID: PMC10828819, DOI: 10.1016/j.jpeds.2023.113583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentArtificial IntelligenceHumansMental HealthPsychotic DisordersRisk FactorsSuicide, AttemptedConceptsEthical implicationsDistinct ethical challengesEthical challengesEthicsInformed consentBroader discussionPolygenic risk scoresClinical utilityRisk scoreSuicide attemptsQuestionsYouth mental health settingsRisk-benefit balancePopulation-level screeningConsumer advertisingPotential clinical utilityMental health settingsAttemptConsentClinical questionsPredictive scoreHealth settingsNarrative literature reviewImplicationsLiterature reviewCoping and sleep quality in youth: An Experience Sampling study
Hagemann N, Kirtley O, Lafit G, Vancampfort D, Wampers M, Decoster J, Derom C, Gülöksüz S, De Hert M, Jacobs N, Menne‐Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin‐Germeys I. Coping and sleep quality in youth: An Experience Sampling study. Journal Of Adolescence 2023, 95: 566-583. PMID: 36647754, DOI: 10.1002/jad.12137.Peer-Reviewed Original ResearchConceptsEmotion-focused copingExperience Sampling StudySleep qualityDaily sleep qualitySample of youthLocus of controlSampling studyUtrecht Coping ListPassive reactionNegative eventsDaily lifeFuture insomniaCopingSleep problemsQuality of sleepMental wellMental healthDisengagementYouthState locusIndividual presentStyleDecreased sleep qualitySleepPsychopathology
2022
Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
Paquin V, Pries L, ten Have M, Bak M, Gunther N, de Graaf R, van Dorsselaer S, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, van Os J, Shah J, Guloksuz S. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry And Psychiatric Epidemiology 2022, 58: 43-52. PMID: 35913550, PMCID: PMC9845157, DOI: 10.1007/s00127-022-02346-3.Peer-Reviewed Original ResearchConceptsSex-specific associationsSelf-reported healthPRS-SCZES-SCZPhysical healthGeneral populationNetherlands Mental Health SurveyIncidence Study-2Mental Health SurveyHealth SurveyRisk scoreAge 65Common genetic variantsHealth correlatesAge 18Poor healthOlder individualsMental healthPolygenic riskLinear mixed modelsAgeSexExposome scoreHealthAssociationEarly intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinicGeneral psychopathology and its social correlates in the daily lives of youth
Achterhof R, Kirtley O, Schneider M, Hagemann N, Hermans K, Hiekkaranta A, Lecei A, Decoster J, Derom C, De Hert M, Gülöksüz S, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. General psychopathology and its social correlates in the daily lives of youth. Journal Of Affective Disorders 2022, 309: 428-436. PMID: 35500686, DOI: 10.1016/j.jad.2022.04.147.Peer-Reviewed Original ResearchBe(com)ing Social: Daily-Life Social Interactions and Parental Bonding
Achterhof R, Schneider M, Kirtley O, Wampers M, Decoster J, Derom C, De Hert M, Guloksuz S, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. Be(com)ing Social: Daily-Life Social Interactions and Parental Bonding. Developmental Psychology 2022, 58: 792-805. PMID: 35343722, DOI: 10.1037/dev0001315.Peer-Reviewed Original ResearchConceptsParental Bonding InstrumentSocial interactionSocial experienceExperience sampling periodChildren's social developmentPositive social experiencesThree-factor structureMore social behaviorSocial developmentYoung adult twinsPsychological autonomyDaily lifeSocial functioningSocial dysfunctionParental bondingSocial behaviorBehavioral freedomSocial worldNontwin siblingsAdult twinsSocial independenceFactor analysisStyle of careSocializationStyle
2021
Association Between Discrimination Stress and Suicidality in Preadolescent Children
Argabright S, Visoki E, Moore T, Ryan D, DiDomenico G, Njoroge W, Taylor J, Guloksuz S, Gur R, Gur R, Benton T, Barzilay R. Association Between Discrimination Stress and Suicidality in Preadolescent Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2021, 61: 686-697. PMID: 34425231, PMCID: PMC8917360, DOI: 10.1016/j.jaac.2021.08.011.Peer-Reviewed Original ResearchEmotion regulation in response to daily negative and positive events in youth: The role of event intensity and psychopathology
Hiekkaranta A, Kirtley O, Lafit G, Decoster J, Derom C, de Hert M, Gülöksüz S, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. Emotion regulation in response to daily negative and positive events in youth: The role of event intensity and psychopathology. Behaviour Research And Therapy 2021, 144: 103916. PMID: 34224990, DOI: 10.1016/j.brat.2021.103916.Peer-Reviewed Original ResearchConceptsEmotion regulationNegative eventsEmotion expressionPositive eventsEmotion regulation effortsSubsequent emotion regulationRole of contextIndividual contextual factorsSituation modificationDegree of effortPsychopathology symptomsYouth sampleRegulation effortsStrategy diversityContextual factorsPsychopathologyCurrent articleYoung peopleEvent intensitySavoringEmotionsRuminationPeopleReappraisalYouthSchizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Wittchen H, Rutten B, Guloksuz S. Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis. Schizophrenia Bulletin 2021, 47: 594-603. PMID: 33693921, PMCID: PMC8084443, DOI: 10.1093/schbul/sbab019.Peer-Reviewed Original ResearchConceptsFixed-effects modelCannabis usePsychotic experiencesGeneral population cohortRandom-effects modelMental health outcomesRisk factorsTime-varying confoundersProspective associationsPopulation cohortHealth outcomesOwn controlCausal associationPsychosisCannabisLongitudinal studyAssociationBetween-person levelConfoundersCohortIncidenceSchizophrenia
2020
Predictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScoresDo Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPainPolygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Pries L, Klingenberg B, Menne‐Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Lin B, Luykx J, Rutten B, van Os J, Guloksuz S. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica 2020, 141: 465-475. PMID: 32027017, PMCID: PMC7318228, DOI: 10.1111/acps.13158.Peer-Reviewed Original ResearchConceptsDaily life stressorsChildhood adversityEmotion dysregulationPositive affectPsychosis pronenessMomentary mental statesEcological momentary assessmentChildhood Trauma QuestionnaireGene-environment correlationNegative affectMental statesMomentary assessmentPsychosis expressionTrauma QuestionnaireAdversityAffectYoung adultsStressorsNovel evidencePolygenic liabilityInteraction effectsPronenessSchizophreniaHigh PRSState domain
2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioningOrganization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study
Xenaki L, Kollias C, Stefanatou P, Ralli I, Soldatos R, Dimitrakopoulos S, Hatzimanolis A, Triantafyllou T, Kosteletos I, Vlachos I, Selakovic M, Foteli S, Mantonakis L, Ermiliou V, Voulgaraki M, Psarra E, Gülöksüz S, van Os J, Stefanis N. Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study. Early Intervention In Psychiatry 2019, 14: 343-355. PMID: 31402581, DOI: 10.1111/eip.12865.Peer-Reviewed Original ResearchConceptsRisk factorsMild functional improvementLongitudinal cohort studySymptom severity criteriaPoor cognitive performanceOutcome of psychosisPreliminary findingsPatients 16Cohort studyAntipsychotic treatmentClinical pictureFEP patientsClinical managementFunctional improvementFamily historyEmergency unitBaseline presentationSeverity criteriaPsychiatric hospitalPsychotic disordersClinical InterviewDrug usePotential associationGene-environment interaction studiesBiochemical parametersToward incorporating genetic risk scores into symptom networks of psychosis
Isvoranu A, Guloksuz S, Epskamp S, van Os J, Borsboom D, Investigators. Toward incorporating genetic risk scores into symptom networks of psychosis. Psychological Medicine 2019, 50: 636-643. PMID: 30867074, PMCID: PMC7093319, DOI: 10.1017/s003329171900045x.Peer-Reviewed Original ResearchEffects of Curcumin on Cognitive Functioning and Inflammatory State in Schizophrenia: A Double-Blind, Placebo-Controlled Pilot Trial.
Kucukgoncu S, Guloksuz S, Tek C. Effects of Curcumin on Cognitive Functioning and Inflammatory State in Schizophrenia: A Double-Blind, Placebo-Controlled Pilot Trial. Journal Of Clinical Psychopharmacology 2019, 39: 182-184. PMID: 30747752, DOI: 10.1097/jcp.0000000000001012.Peer-Reviewed Original ResearchPsychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls
Çevik B, Mançe-Çalışır Ö, Atbaşoğlu E, Saka M, Alptekin K, Üçok A, Sırmatel B, Gülöksüz S, Tükün A, van Os J, Gümüş-Akay G. Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls. Journal Of Psychiatric Research 2019, 111: 169-185. PMID: 30776705, DOI: 10.1016/j.jpsychires.2019.01.022.Peer-Reviewed Original ResearchConceptsShorter telomere lengthLonger telomere lengthChildhood adversityTelomere lengthUnaffected siblingsSCZ patientsChronic medical disordersCourse of schizophreniaSimilar telomere lengthPsychotic-like symptomsHypothesis patientsClinical presentationNon-clinical controlsMedical disordersGeneral populationFunctioning scoresPatientsSchizophrenia patientsSocio-demographic featuresGlobal assessmentEarly onsetSchizophreniaLife expectancyAges 0Potential role