2024
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociationT78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK
Lin B, Pries L, Magnasco A, Gülöksüz S. T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK. European Neuropsychopharmacology 2024, 87: 195-196. DOI: 10.1016/j.euroneuro.2024.08.388.Peer-Reviewed Original ResearchExposome-wide association studyPolygenic risk scoresPRS-SCZGene-environment interactionsGene-environment interaction studiesPsychotic experiencesAssociation studiesPhysical health outcomesLogistic regression modelsNon-psychotic disordersHealth outcomesUK BiobankMental distressNominal significanceRisk scoreMedical conditionsSleep problemsSelf-harm behaviorsRegression modelsAdditive interactionGxE interactionsAgnostic analysisGxEGenetic underpinningsExposure to PE401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank
Lin B, Pries L, Magnasco A, Guloksuz S. 401. Gene-Environment Interaction Study on the Correlates for Psychotic Experiences in the UK Biobank. Biological Psychiatry 2024, 95: s264. DOI: 10.1016/j.biopsych.2024.02.900.Peer-Reviewed Original ResearchThe relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.
Üçok A, Noyan H, Gülöksüz S, Saka M, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Şahin Cankurtaran E, Ulusoy Kaymak S, Rutten B, van Os J. The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study. Psychological Medicine 2024, 54: 2414-2425. PMID: 38606591, DOI: 10.1017/s0033291724000540.Peer-Reviewed Original ResearchNegative cognitive schemasChildhood traumaCognitive schemasPsychotic symptomsEU-GEIEmotional abuseBrief Core Schema ScalesEU-GEI studySubthreshold psychotic experiencesSubtypes of traumaChildhood emotional abuseChildhood Trauma QuestionnaireNon-clinical populationsHealthy controlsNegative schemasPositive symptomsPersecutory delusionsPsychotic experiencesSchema ScaleTrauma QuestionnaireChildhood abuseSymptom severitySchizophreniaSexual abuseAbuse
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther support
2021
What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder?
Hasmi L, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Richards A, Lin B, O'Donovan M, Luykx J, Rutten B, Guloksuz S, van Os J. What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder? Epidemiology And Psychiatric Sciences 2021, 30: e53. PMID: 34225831, PMCID: PMC8264801, DOI: 10.1017/s204579602100041x.Peer-Reviewed Original ResearchConceptsNon-psychotic disordersClinical high-risk stateClinical high riskHigh-risk stateHigh riskPsychotic symptomsPsychotic experiencesProspective general population cohortEarly psychotic experiencesIncident psychotic experiencesGeneral population cohortHealth service usePsychosis risk statesDrug use disordersPositive family historySchizophrenia polygenic risk scoresPsychosis incidenceAntipsychotic medicationYearly incidenceFamily historyPolygenic risk scoresRisk scoreAPS researchPRS-SZService useSchizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Wittchen H, Rutten B, Guloksuz S. Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis. Schizophrenia Bulletin 2021, 47: 594-603. PMID: 33693921, PMCID: PMC8084443, DOI: 10.1093/schbul/sbab019.Peer-Reviewed Original ResearchConceptsFixed-effects modelCannabis usePsychotic experiencesGeneral population cohortRandom-effects modelMental health outcomesRisk factorsTime-varying confoundersProspective associationsPopulation cohortHealth outcomesOwn controlCausal associationPsychosisCannabisLongitudinal studyAssociationBetween-person levelConfoundersCohortIncidenceSchizophrenia
2020
The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Simons C, Gunther N, Henquet C, Pries L, Guloksuz S, Bak M, van Os J. The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2. Psychological Medicine 2020, 51: 1696-1703. PMID: 32174291, PMCID: PMC8327623, DOI: 10.1017/s0033291720000446.Peer-Reviewed Original Research
2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioning
2018
Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population
Reininghaus U, Rauschenberg C, Have M, de Graaf R, van Dorsselaer S, Simons CJP, Gunther N, Pries LK, Guloksuz S, Radhakrishnan R, Bak M, van Os J. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population. Psychological Medicine 2018, 49: 1799-1809. PMID: 30160228, DOI: 10.1017/s0033291718002209.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewAffective disturbancesPsychotic experiencesNetherlands Mental Health SurveySecond Netherlands Mental Health SurveyTransdiagnostic phenotypeJTC biasMental Health SurveyDose-response relationshipGeneral population sampleHealth SurveyGeneral populationIncidence studyHelp-seeking behaviorDiagnostic InterviewTime pointsMemory performanceConclusions reasoning biasPopulation sampleRecent findingsPhenotypeDigit span taskIndividualsFindingsPsychosisO4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS?
Pries L, Guloksuz S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Klingenberg B, Cinar O, Lin B, Luykx J, Rutten B, van Os J. O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS? Schizophrenia Bulletin 2018, 44: s84-s84. PMCID: PMC5887471, DOI: 10.1093/schbul/sby015.210.Peer-Reviewed Original ResearchEvent-related stressMomentary stressStress reactivityMain effectSocial stressPsychotic experiencesYoung adult twin sampleEffect of PRSHeightened emotional reactivityAdditional explorative analysesAdult twin sampleEmotion regulationSignificant main effectEmotion reactivityNeuropsychological mechanismsEmotional reactivityMultilevel regression analysisEmotional fluctuationsMinor stressorsLife stressorsSubjective experiencePolygenic risk scoresDiary techniqueDiary methodTwin sampleT115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Gunther N, Pries L, Guloksuz S, Radhakrishnan R, Bak M, van Os J. T115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION. Schizophrenia Bulletin 2018, 44: s160-s161. PMCID: PMC5888643, DOI: 10.1093/schbul/sby016.391.Peer-Reviewed Original ResearchComposite International Diagnostic InterviewHelp-seeking behaviorAffective disturbancesGeneral populationPsychotic experiencesTransdiagnostic phenotypeNetherlands Mental Health SurveyJTC biasSecond Netherlands Mental Health SurveyMental Health SurveyRepresentative general population sampleDose-response relationshipGeneral population sampleMemory performanceSocio-demographic characteristicsRisk factorsHealth SurveyIncidence studySocio-environmental factorsDiagnostic InterviewCognitive deficitsMental healthSymptom domainsTime pointsPsychosis
2017
A critique of the “ultra‐high risk” and “transition” paradigm
van Os J, Guloksuz S. A critique of the “ultra‐high risk” and “transition” paradigm. World Psychiatry 2017, 16: 200-206. PMID: 28498576, PMCID: PMC5428198, DOI: 10.1002/wps.20423.Peer-Reviewed Original ResearchClinical high riskUltra-high riskCommon mental disordersMental disordersPsychotic experiencesCHR researchHigh-risk approachMental health problemsPublic health perspectiveFalse-positive findingsTransdiagnostic expressionClinical picturePoor outcomePoor prognosisFunctional outcomeBaseline differencesHigh riskOmega-3Health problemsPositive findingsEpidemiological researchDiagnostic shiftUHR sampleYoung individualsHealth perspective
2015
Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma