2024
F85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. F85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS. European Neuropsychopharmacology 2024, 87: 251. DOI: 10.1016/j.euroneuro.2024.08.496.Peer-Reviewed Original ResearchConcordant effect directionsLinkage disequilibrium score regressionGenome-wide association study dataCell adhesion molecule bindingGenetic architectureBrain measuresPolygenic scoresBrain phenotypesUnique genesGene OntologyBrain structuresConjunctional false discovery rateLinkage disequilibrium score regression analysisGenetic correlationsGenetic risk of schizophreniaComplex genetic architectureHeritable brain disorderKyoto Encyclopedia of GenesAssociated with schizophreniaInsignificant genetic correlationResting-state fMRIWhite matter integrityEncyclopedia of GenesPostsynaptic densityRisk of schizophrenia
2023
Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sample
2021
Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealth