2022
Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinic
2020
Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Pries L, Klingenberg B, Menne‐Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Lin B, Luykx J, Rutten B, van Os J, Guloksuz S. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica 2020, 141: 465-475. PMID: 32027017, PMCID: PMC7318228, DOI: 10.1111/acps.13158.Peer-Reviewed Original ResearchConceptsDaily life stressorsChildhood adversityEmotion dysregulationPositive affectPsychosis pronenessMomentary mental statesEcological momentary assessmentChildhood Trauma QuestionnaireGene-environment correlationNegative affectMental statesMomentary assessmentPsychosis expressionTrauma QuestionnaireAdversityAffectYoung adultsStressorsNovel evidencePolygenic liabilityInteraction effectsPronenessSchizophreniaHigh PRSState domain