2024
Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study
Moreno-Gamazo N, Pries L, Marqués-Feixa L, Papiol S, Romero S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, van Os J, Rutten B, Fañanás L, Guloksuz S. Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study. Journal Of Affective Disorders 2024, 370: 118-123. PMID: 39488234, DOI: 10.1016/j.jad.2024.10.125.Peer-Reviewed Original ResearchChildhood traumaSuicidal ideationPsychiatric evaluation of patientsSCL-90-R.Environmental risk factorsGene-environment correlationHistory of CTSample of twinsTwin analysesGenetic vulnerabilityPsychiatric evaluationRisk factorsTwin studiesTwin pairsPhysical abuseEvaluation of patientsDizygotic twinsGenetic riskIdeationProtective factorsPsychosocial environmentIndividual characteristicsGenetic predispositionIncreased riskTotal CT
2023
T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental health
2022
Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphisms
2020
M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY
Pries L, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Li B, Luykx J, Rutten B, van Os J, Guloksuz S. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY. Schizophrenia Bulletin 2020, 46: s183-s183. PMCID: PMC7234581, DOI: 10.1093/schbul/sbaa030.438.Peer-Reviewed Original ResearchAdult stressful life eventsAssociations of SLEsStressful life eventsGeneral populationPhysical healthMental healthHealth SurveyHealth outcomesShort Form-36 Health SurveyNetherlands Mental Health SurveyImpact of SLEsRecent stressful life eventsProspective cohort studyPrevious health statusMental Health SurveyDutch general populationLife eventsCohort studyProspective surveyPolygenic risk scoresRisk scoreGene-environment interactionsGenetic predispositionHealth statusSchizophrenia
2018
Higher schizotypy predicts better metabolic profile in unaffected siblings of patients with schizophrenia
Atbasoglu E, Gumus-Akay G, Guloksuz S, Saka M, Ucok A, Alptekin K, Gullu S, van Os J. Higher schizotypy predicts better metabolic profile in unaffected siblings of patients with schizophrenia. Psychopharmacology 2018, 235: 1029-1039. PMID: 29306964, DOI: 10.1007/s00213-017-4818-z.Peer-Reviewed Original ResearchConceptsInsulin resistanceDopaminergic activityMetabolic profileHomeostatic model assessmentHDL-C levelsBetter metabolic profilesFavorable metabolic profilePancreatic insulin secretionUnaffected siblingsBeads taskResultsInsulin resistanceTertile groupRegression modelsCentral actionInsulin secretionGeneral populationGenetic predispositionGlucose metabolismModel assessmentSZ patientsRegulatory roleDirect actionSignificant predictorsHigher likelihoodLongitudinal study