2024
T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK
Lin B, Pries L, Magnasco A, Gülöksüz S. T78. GENE-ENVIRONMENT INTERACTION STUDY ON THE CORRELATES FOR PSYCHOTIC EXPERIENCES IN THE UK BIOBANK. European Neuropsychopharmacology 2024, 87: 195-196. DOI: 10.1016/j.euroneuro.2024.08.388.Peer-Reviewed Original ResearchExposome-wide association studyPolygenic risk scoresPRS-SCZGene-environment interactionsGene-environment interaction studiesPsychotic experiencesAssociation studiesPhysical health outcomesLogistic regression modelsNon-psychotic disordersHealth outcomesUK BiobankMental distressNominal significanceRisk scoreMedical conditionsSleep problemsSelf-harm behaviorsRegression modelsAdditive interactionGxE interactionsAgnostic analysisGxEGenetic underpinningsExposure to PE
2023
T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental healthThe association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study
Erzin G, Atbaşoğlu C, Fusar-Poli L, Saka M, Üçok A, Alptekin K, Os J, Akay G, Gülöksüz S. The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study. European Psychiatry 2023, 66: s264-s264. PMCID: PMC10596217, DOI: 10.1192/j.eurpsy.2023.601.Peer-Reviewed Original ResearchMetabolic parametersHealthy controlsES-SCZHigh-density lipid levelsDiastolic blood pressureNational Schizophrenia NetworksExposome scorePhysical health outcomesBlood pressureAnalysis ageLipid levelsGlucose levelsGene-environment interactionsPsychosis developmentLinear regression analysisHealth outcomesPrenatal periodSchizophrenia NetworkSchizophreniaClinical implementationEnvironmental exposuresEUGEI studyNongenetic exposuresRegression analysisImportant metabolic parameters
2021
Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealth
2020
M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY
Pries L, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Li B, Luykx J, Rutten B, van Os J, Guloksuz S. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY. Schizophrenia Bulletin 2020, 46: s183-s183. PMCID: PMC7234581, DOI: 10.1093/schbul/sbaa030.438.Peer-Reviewed Original ResearchAdult stressful life eventsAssociations of SLEsStressful life eventsGeneral populationPhysical healthMental healthHealth SurveyHealth outcomesShort Form-36 Health SurveyNetherlands Mental Health SurveyImpact of SLEsRecent stressful life eventsProspective cohort studyPrevious health statusMental Health SurveyDutch general populationLife eventsCohort studyProspective surveyPolygenic risk scoresRisk scoreGene-environment interactionsGenetic predispositionHealth statusSchizophrenia
2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioningReplicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatientsExamining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Guloksuz S, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş‐Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García‐Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez‐López E, Arrojo M, Carracedo A, López G, González‐Peñas J, Parellada M, Maric N, Atbaşog˘lu C, Ucok A, Alptekin K, Saka M, investigators G, Arango C, O'Donovan M, Rutten B, van Os J. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 2019, 18: 173-182. PMID: 31059627, PMCID: PMC6502485, DOI: 10.1002/wps.20629.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersEnvironmental exposuresGene-environment interactionsEtiopathogenesis of schizophreniaAdditive interactionEarly life adversityEarly TwinSeason of birthPolygenic risk scoresSpectrum disorderMultiple common genetic variantsRisk scoreRegular cannabisLifetime historyJoint associationsPRS-SCZCommon genetic variantsHearing impairmentSchizophreniaUnrelated controlsEUGEI studyDisordersFamily studiesGenetic liabilityRisk state