2023
Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis
Ku B, Addington J, Bearden C, Cadenhead K, Cannon T, Compton M, Cornblatt B, Druss B, Gülöksüz S, Mathalon D, Perkins D, Tsuang M, Walker E, Woods S, Carrión R. Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 1437-1446. PMID: 37358832, PMCID: PMC10686327, DOI: 10.1093/schbul/sbad093.Peer-Reviewed Original ResearchConceptsClinical high riskHealthy comparisonsSocial functioningHigh riskPoor social functioningNorth American Prodrome Longitudinal StudyImportant risk factorRisk factorsPsychotic disordersEffective interventionsHealthy youthChildhoodLongitudinal studyAdulthoodPsychosisAssociationAdultsMaladaptationRiskSocial deficitsFurther researchFunctioningCommunity levelThe association between polygenic risk scores for mental disorders and social cognition: A scoping review
Fusar-Poli L, Rodolico A, Martinez M, Fichera C, Lin B, Basadonne I, Concerto C, Aguglia E, Guloksuz S, Signorelli M. The association between polygenic risk scores for mental disorders and social cognition: A scoping review. Journal Of Psychiatric Research 2023, 164: 389-401. PMID: 37418886, DOI: 10.1016/j.jpsychires.2023.06.029.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial cognitionMental disordersAttention deficit hyperactivity disorderReal-world functioningSC deficitsEmotion recognitionHyperactivity disorderSpectrum disorderPresent impairmentsPolygenic risk scoresCognitionFuture researchMolecular genetic riskSignificant difficultiesSpecific disordersDisordersUnaffected relativesGenetic riskRisk scorePeopleUnderstanding of mechanismsFunctioningEnvironmental risk factorsScores
2021
Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis
Oomen P, Begemann M, Brand B, de Haan L, Veling W, Koops S, van Os J, Smit F, Bakker P, van Beveren N, Boonstra N, Gülöksüz S, Kikkert M, Lokkerbol J, Marcelis M, Rosema B, de Beer F, Gangadin S, Geraets C, van ‘t Hag E, Haveman Y, van der Heijden I, Voppel A, Willemse E, van Amelsvoort T, Bak M, Batalla A, Been A, van den Bosch M, van den Brink T, Faber G, Grootens K, de Jonge M, Knegtering R, Kurkamp J, Mahabir A, Pijnenborg G, Staring T, Veen N, Veerman S, Wiersma S, Graveland E, Hoornaar J, Sommer I. Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis. Psychological Medicine 2021, 53: 2317-2327. PMID: 34664546, PMCID: PMC10123843, DOI: 10.1017/s0033291721004153.Peer-Reviewed Original ResearchConceptsDistinct cognitive subgroupsCognitive subgroupsFirst-episode psychosisDiscrete cognitive profilesGeneral functioningTrend-level effectsCognitive profileSelf-reported functional outcomesCognitive clustersCognitive deficitsCognitionBrief assessmentFunctional outcomeLarge sampleFEP patientsClinical outcomesCurrent resultsSevere clinical symptomsPsychosisEarly identificationHealthy controlsCluster analysisClinical symptomsFunctioningDeficits
2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioning