2022
Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphisms
2021
Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Gunther N, Luykx J, Rutten B, Guloksuz S. Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis. Psychological Medicine 2021, 53: 1825-1833. PMID: 37310330, PMCID: PMC10106290, DOI: 10.1017/s0033291721003445.Peer-Reviewed Original ResearchConceptsClinical characterizationPolygenic risk scoresClinical valueProspective general population cohortGeneral population cohortUse of medicationsPopulation attributable fractionPrediction of needDSM-IV diagnosisHealth care outcomesSymptom dimensionsTransdiagnostic frameworkClinical factorsAttributable fractionEtiological factorsRisk scoreCare outcomesCategorical algorithmService usePopulation cohortSociodemographic factorsTransdiagnostic symptom dimensionsPhysical healthDiagnosisDSM diagnoses