2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomesAssociations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Verplaetse TL, Peltier MR, Roberts W, Moore KE, Pittman BP, McKee SA. Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study. Nicotine & Tobacco Research 2020, 22: 1316-1321. PMID: 32152625, PMCID: PMC7364844, DOI: 10.1093/ntr/ntaa022.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioFaster nicotine metabolismHigher nicotine metabolite ratioE-cigarette useCigarette smoking statusSlower nicotine metabolismNicotine metabolismE-cigarettesSmoking statusCigarette smokingMetabolite ratiosE-cigarette use statusPopulation-based studyLongitudinal cohort studyWave 1Cigarette smoking behaviorCohort studyClinical trialsTobacco usePATH studyHealth StudySmoking behaviorEarly interventionUS populationCombustible cigarettes
2018
Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking
Roberts W, Ralevski E, Verplaetse TL, McKee SA, Petrakis IL. Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. Journal Of Substance Use And Addiction Treatment 2018, 94: 91-96. PMID: 30243424, PMCID: PMC6154389, DOI: 10.1016/j.jsat.2018.08.015.Peer-Reviewed Original ResearchConceptsAlcohol use disorderClinical trialsSmoking outcomesNicotinic acetylcholine receptor antagonistAlcohol useHigh-dependence smokersEffects of mecamylamineSubgroups of smokersAcetylcholine receptor antagonistHigh tobacco dependencePlacebo groupMedication conditionReceptor antagonistMedication effectsTobacco dependenceTobacco useTreatment respondersMecamylamineSmokingTreatment phaseUse disordersAlcohol dependenceSmokersTrialsSignificant differencesEffects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users
Roberts W, Shi JM, Tetrault JM, McKee SA. Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users. Journal Of Addiction Medicine 2018, 12: 227-233. PMID: 29438157, PMCID: PMC5970035, DOI: 10.1097/adm.0000000000000392.Peer-Reviewed Original ResearchConceptsLow-dose naltrexoneTobacco usersTreatment outcomesPlacebo-controlled human laboratory studySmoking cessation treatmentEffects of vareniclineCigarettes ad libitumHuman laboratory studiesSubjective drug effectsVarenicline monotherapyCessation medicationsMedication therapyCessation treatmentMedication armTobacco useVareniclineLow doseSmoking relapseSmokingDrug effectsSmoking outcomesSmoking behaviorNaltrexoneCarbon monoxide levelsHeavy drinkers
2016
An overview of alcohol and tobacco/nicotine interactions in the human laboratory
Verplaetse TL, McKee SA. An overview of alcohol and tobacco/nicotine interactions in the human laboratory. The American Journal Of Drug And Alcohol Abuse 2016, 43: 186-196. PMID: 27439453, PMCID: PMC5588903, DOI: 10.1080/00952990.2016.1189927.Peer-Reviewed Original ResearchConceptsAlcohol-tobacco interactionsNicotine interactionsHuman laboratorySubjective responsesBlood alcohol curveDrinking cuesAlcohol use disorderOverview of alcoholNicotine deprivationSelf-administration behaviorDrugs of abuseAlcohol cravingReciprocal influenceAlcohol curveAlcohol influenceSubjective effectsUse disordersTobacco/nicotineNicotine administrationTobacco useInteractive effectsCravingMajor public health concernPublic health concernDrinkersTargeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings
Verplaetse TL, McKee SA. Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings. Current Addiction Reports 2016, 3: 314-322. PMID: 31275802, PMCID: PMC6609087, DOI: 10.1007/s40429-016-0115-x.Peer-Reviewed Original ResearchBrain stress systemsTobacco useNoradrenergic systemTreatment strategiesCorticotropin-releasing factor (CRF) systemTobacco/nicotine dependenceMajority of smokersNicotine-induced activationPotential treatment strategySmoking-related outcomesNicotine-motivated behaviorsLong-term abstinenceStress systemClinical findingsAdrenal axisTobacco dependencePreventable mortalityClinical investigationNicotine dependenceRecent FindingsOneTherapeutic benefitPharmacological agentsCRF systemDrug AdministrationSummaryThis review
2015
Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence
Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence. Nicotine & Tobacco Research 2015, 17: 486-495. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.Peer-Reviewed Original ResearchConceptsSmoking cessationNoradrenergic systemClinical evidenceTobacco dependenceNoradrenergic activityMedication developmentPoor smoking cessation outcomesCause of morbiditySmoking cessation outcomesStress reactivitySex-specific mechanismsLower quit ratesNicotine-related reinforcementCurrent medicationsMedication effectivenessNicotine reinforcementCessation outcomesNoradrenergic agentsQuit ratesTreatment strategiesTobacco useNoradrenergic compoundsSmoking outcomesTreatment developmentWomen
2014
Smoking and mental illness in the US population
Smith PH, Mazure CM, McKee SA. Smoking and mental illness in the US population. Tobacco Control 2014, 23: e147. PMID: 24727731, PMCID: PMC4201650, DOI: 10.1136/tobaccocontrol-2013-051466.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHealth Status DisparitiesHumansLongitudinal StudiesMaleMental DisordersMental Health ServicesMiddle AgedPrevalenceSmokingSmoking CessationSocioeconomic FactorsTobacco Use DisorderYoung AdultConceptsPsychiatric diagnosisCessation ratesQuit ratesSpecific diagnosisMental health service useEstimates of smokingHealth service useCurrent psychiatric diagnosisSpecific psychiatric diagnosesNational Epidemiologic SurveyTimes greater oddsPast-year psychiatric diagnosisHeavy smokingPsychiatric comorbiditySmoking ratesTobacco useTreatment useComorbid disordersSmokingGreater prevalenceService useEpidemiologic SurveyGreater oddsCohort surveyUS population
2013
The association of tobacco use and gender to cardiac rehabilitation outcomes: a preliminary investigation
Weinberger AH, Mazure CM, McKee SA, Caulin-Glaser T. The association of tobacco use and gender to cardiac rehabilitation outcomes: a preliminary investigation. Journal Of Substance Use 2013, 19: 171-175. PMID: 24817825, PMCID: PMC4011657, DOI: 10.3109/14659891.2013.765515.Peer-Reviewed Original ResearchCardiac rehabilitation outcomesFormer tobacco usersTobacco useRisk factorsTobacco usersRehabilitation outcomesCardiovascular disease risk factor reductionCR entryCardiovascular risk factor modificationKey cardiovascular risk factorsComprehensive CR programRisk factor modificationRisk factor reductionCardiovascular risk factorsCVD risk factorsMaximal exercise capacityNon-HDL cholesterolRetrospective cohort analysisTarget goalsExercise capacityPrimary outcomeTotal cholesterolCardiac statusCR programFactor modification
2012
How Can We Use Our Knowledge of Alcohol-Tobacco Interactions to Reduce Alcohol Use?
McKee SA, Weinberger AH. How Can We Use Our Knowledge of Alcohol-Tobacco Interactions to Reduce Alcohol Use? Annual Review Of Clinical Psychology 2012, 9: 649-674. PMID: 23157448, PMCID: PMC3651830, DOI: 10.1146/annurev-clinpsy-050212-185549.Peer-Reviewed Original ResearchSmoke-free policies in drinking venues predict transitions in alcohol use disorders in a longitudinal U.S. sample
Young-Wolff KC, Hyland AJ, Desai R, Sindelar J, Pilver CE, McKee SA. Smoke-free policies in drinking venues predict transitions in alcohol use disorders in a longitudinal U.S. sample. Drug And Alcohol Dependence 2012, 128: 214-221. PMID: 22999418, PMCID: PMC4052952, DOI: 10.1016/j.drugalcdep.2012.08.028.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSmoke-free legislationSmoke-free policiesAUD remissionUse disordersLikelihood of AUDWave IIndoor public venuesLongitudinal U.S. sampleTobacco-related diseasesYounger age groupsNational Epidemiological SurveySmoke-free barsPublic health benefitsAUD onsetHigh comorbidityProtective effectCurrent drinkersTobacco useEpidemiological surveyAge groupsLogistic regressionRelated conditionsHeavy drinkingLower likelihood
2007
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
McKee SA, O’Malley S, Shi J, Mase T, Krishnan-Sarin S. Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology 2007, 196: 189-200. PMID: 17912500, PMCID: PMC2862181, DOI: 10.1007/s00213-007-0952-3.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdultAlcohol DrinkingBlood PressureChromatography, High Pressure LiquidDose-Response Relationship, DrugDouble-Blind MethodDrinking BehaviorFemaleHeart RateHumansMaleMiddle AgedMonitoring, PhysiologicNicotineOscillometrySelf AdministrationSelf-AssessmentSkin TemperatureSmoking PreventionSpectrophotometry, UltravioletSurveys and QuestionnairesTime FactorsConceptsTransdermal nicotine replacementNicotine replacementSelf-administration periodPriming drinkHeavy drinkersPatch applicationNicotine deprivationAlcohol responsesNicotine patch conditionPlacebo patch conditionDouble-blind studySystolic blood pressureHeavy drinking smokersPatch conditionsAlcohol drinking behaviorTransdermal patch applicationDrinking behaviorInitiation of drinkingBlood pressurePlacebo patchAdditional drinkDaily smokersTobacco cravingTobacco useHeart rateGender Differences in Association with Substance Use Diagnoses and Smoking
Husky MM, Paliwal P, Mazure CM, McKee SA. Gender Differences in Association with Substance Use Diagnoses and Smoking. Journal Of Addiction Medicine 2007, 1: 161-164. PMID: 21768952, DOI: 10.1097/adm.0b013e318142d06c.Peer-Reviewed Original ResearchDrug use diagnosesUse diagnosesCurrent alcoholOccasional smokersUse disordersGreater oddsCurrent alcohol use disorderDrug use disordersSecondary prevention effortsSubstance use diagnosesNational Epidemiologic SurveyAlcohol use disorderGender-specific associationsConcurrent substance useSubstantial health risksFormer smokersSmoking statusSimilar oddsOdds ratioDaily smokersDrug diagnosesTobacco useEpidemiologic SurveySmoking behaviorSmokers
2004
Survey of subjective effects of smoking while drinking among college students
McKee SA, Hinson R, Rounsaville D, Petrelli P. Survey of subjective effects of smoking while drinking among college students. Nicotine & Tobacco Research 2004, 6: 111-117. PMID: 14982695, DOI: 10.1080/14622200310001656939.Peer-Reviewed Original ResearchConceptsInfluence of alcoholTobacco useSubjective effectsGreater subjective effectsWeekly alcohol consumptionCollege studentsStronger subjective effectsMean ageFirst-year college studentsSmoking ratesSmoking episodesSmokersAlcohol consumptionConcurrent alcoholSmokingStandard drinksAlcohol useDrinking episodesSubjective reactivityRegular useCollege-age populationPositive reinforcementSignificant percentagePositive experiencesWeeks
2003
Sex differences in the effects of stressful life events on changes in smoking status
McKee SA, Maciejewski PK, Falba T, Mazure CM. Sex differences in the effects of stressful life events on changes in smoking status. Addiction 2003, 98: 847-855. PMID: 12780373, DOI: 10.1046/j.1360-0443.2003.00408.x.Peer-Reviewed Original ResearchConceptsStressful life eventsLife eventsSmoking statusAdverse financial eventsCurrent smokersHealth eventsCommunity-based sampleOccurrence of relapseImportant risk factorAdverse health eventsSubstance useFormer smokersFinancial eventsRisk factorsLogistic regression proceduresOdds ratioTobacco useAmericans' ChangingInteractive effectsSex differencesSmokersGreater deleterious effectWomenAbstinenceSmoking