2022
Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort
Reese PP, Doshi MD, Hall IE, Besharatian B, Bromberg JS, Thiessen-Philbrook H, Jia Y, Kamoun M, Mansour SG, Akalin E, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort. American Journal Of Kidney Diseases 2022, 81: 222-231.e1. PMID: 36191727, PMCID: PMC9868058, DOI: 10.1053/j.ajkd.2022.08.011.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesBiopsy-proven acute rejectionAcute kidney injuryNeutrophil gelatinase-associated lipocalinDe novo DSAGraft failurePrimary outcomeAcute rejectionKidney recipientsKidney injurySecondary outcomesAcute Kidney Injury Network criteriaClinical acute kidney injuryNovo donor-specific antibodiesSignificant associationKidney injury molecule-1Recipient alloimmune responsesUrinary IL-18Donor-specific antibodiesFirst posttransplant yearKidney transplant recipientsInjury molecule-1Gelatinase-associated lipocalinDeceased donor kidneysFine-Gray modelClinically adjudicated deceased donor acute kidney injury and graft outcomes
Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryGraft failureAKI phenotypesKidney injuryUrine biomarkersLack of associationAKI casesGraft functionHigher DGFPotential kidneyGraft outcomeDeceased donorsOrgan utilizationMCP-1YKL-40Donor StudyEGFRDGFAncillary analysisAvailable chartsBiomarkersInjuryPhenotypeAssociation
2021
Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation
Alasfar S, Hall IE, Mansour SG, Jia Y, Thiessen-Philbrook HR, Weng FL, Singh P, Schröppel B, Muthukumar T, Mohan S, Malik RF, Harhay MN, Doshi MD, Akalin E, Bromberg JS, Brennan DC, Reese PP, Parikh CR. Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation. BMC Nephrology 2021, 22: 26. PMID: 33435916, PMCID: PMC7802150, DOI: 10.1186/s12882-021-02231-2.Peer-Reviewed Original ResearchConceptsKidney Donor Profile IndexRAAS inhibitorsRisk factorsLower kidney donor profile indexDeceased donor kidney transplantationWorld Health Organization criteriaHigh kidney donor profile indexCurrent transplant practiceHigh-quality kidneysPost-transplant erythrocytosisDonor kidney transplantationMajority of patientsLarge recent cohortPolycystic kidney diseaseRisk of PTEsKidney recipientsTransplant erythrocytosisCerebrovascular eventsKidney transplantationPTE patientsConclusionsThe incidenceGraft failureContemporary incidenceDeceased donorsKidney disease
2020
Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBiomarkersCells, CulturedDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHistocompatibility Antigens Class IIHumansKidneyKidney TransplantationMacrophagesMaleMiceMiddle AgedOsteopontinProspective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsUnited StatesUromodulinConceptsGraft failureGraft functionGraft outcomePrimary outcomeMajor histocompatibilityDeath-censored graft failureDeceased donor kidney transplantationCause graft failureImproved graft survivalRecipient graft outcomesKidney graft outcomeGlomerular filtration rateDeceased donor kidneysTime of procurementGraft survivalKidney transplantationDirection of associationDeceased donorsFiltration rateKidney qualityLower riskExtensive injuryDonor urineSimilar associationMouse macrophagesUrine Injury Biomarkers Are Not Associated With Kidney Transplant Failure.
Koyawala N, Reese PP, Hall IE, Jia Y, Thiessen-Philbrook HR, Mansour SG, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Urine Injury Biomarkers Are Not Associated With Kidney Transplant Failure. Transplantation 2020, 104: 1272-1279. PMID: 31568213, PMCID: PMC7384615, DOI: 10.1097/tp.0000000000002948.Peer-Reviewed Original ResearchConceptsAcute kidney injuryDonor Acute Kidney InjuryGraft failureInjury biomarkersSerum creatinineGraft outcomeKidney injuryComposite outcomeDeath-censored graft failureRisk of GFKidney injury molecule-1Cox proportional hazards modelLiver-type fatty acidSimilar allograft survivalStructural kidney damageKidney transplant recipientsInjury molecule-1Kidney transplant failureGlomerular filtration rateProportional hazards modelAKI kidneysAllograft survivalTransplant recipientsChart reviewNeutrophil gelatinaseAssociation of Deceased Donor Acute Kidney Injury With Recipient Graft Survival
Liu C, Hall IE, Mansour S, Philbrook H, Jia Y, Parikh CR. Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival. JAMA Network Open 2020, 3: e1918634. PMID: 31913491, PMCID: PMC6991314, DOI: 10.1001/jamanetworkopen.2019.18634.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryRecipient graft survivalDeath-censored graft failureCause graft failureAKI kidneysDeceased donorsGraft failureGraft survivalOrgan procurement organizationsAKI statusGraft functionKidney injuryPrimary nonfunctionMean agePropensity score-matched cohort studyTerminal serum creatinine levelPropensity score-matched analysisFollowing secondary outcomesDelayed graft functionSerum creatinine levelsProcurement organizationsDeceased donor kidneysDates of analysisAKI stage
2019
The authors reply
Hall IE, Jia Y, Thiessen-Philbrook HR, Greene T, Parikh CR, Consortium D, Akalin E, Bromberg J, Doshi M, Harhay M, Hall I, Jia Y, Mansour S, Mohan S, Muthukumar T, Reese P, Schröppel B, Singh P, Thiessen-Philbrook H, Weng F, Parikh C. The authors reply. Kidney International 2019, 96: 520-521. PMID: 31331474, DOI: 10.1016/j.kint.2019.04.017.Peer-Reviewed Original Research
2018
Reliability of deceased‐donor procurement kidney biopsy images uploaded in United Network for Organ Sharing
Mansour SG, Hall IE, Reese PP, Jia Y, Thiessen‐Philbrook H, Moeckel G, Weng FL, Revelo MP, Khalighi MA, Trivedi A, Doshi MD, Schröppel B, Parikh CR. Reliability of deceased‐donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. Clinical Transplantation 2018, 32: e13441. PMID: 30387908, PMCID: PMC6317379, DOI: 10.1111/ctr.13441.Peer-Reviewed Original ResearchDeceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia time