An exploratory analysis of the impact of area-level exposome on geographic disparities in aggressive prostate cancer
Wiese D, DuBois T, Sorice K, Fang C, Ragin C, Daly M, Reese A, Henry K, Lynch S. An exploratory analysis of the impact of area-level exposome on geographic disparities in aggressive prostate cancer. Scientific Reports 2024, 14: 16900. PMID: 39075110, PMCID: PMC11286755, DOI: 10.1038/s41598-024-63726-0.Peer-Reviewed Original ResearchConceptsSocial determinants of health domainsElevated oddsTract-level povertyAggressive prostate cancer casesExposome researchDesign targeted interventionsAssociated with raceAggressive prostate cancerSocial determinantsCancer burdenHealth domainsGeographic disparitiesLocal cancer burdenHealth insuranceLogistic regressionExposome factorsAssociation studiesRisk factorsOddsResidential locationExposomeGeographical areasExploratory analysisProstate cancerHealthFactors Associated With Racial and Ethnic Disparities in Locally Advanced Rectal Cancer Outcomes
Shulman R, Deng M, Handorf E, Meyer J, Lynch S, Arora S. Factors Associated With Racial and Ethnic Disparities in Locally Advanced Rectal Cancer Outcomes. JAMA Network Open 2024, 7: e240044. PMID: 38421650, PMCID: PMC10905315, DOI: 10.1001/jamanetworkopen.2024.0044.Peer-Reviewed Original ResearchConceptsPathological complete responseLocally advanced rectal cancerSocial determinants of healthRate of pathological complete responseNon-Hispanic Black patientsNon-Hispanic white patientsDeterminants of healthNational Cancer DatabaseNeoadjuvant therapyPN0 statusTumor downstagingSocial determinantsEthnic disparitiesRectal cancerCancer DatabaseRates of tumor downstagingWhite patientsLymph node-positive diseaseNon-Hispanic black raceTreatment outcomesBlack patientsAssociated with treatment responseNon-Hispanic blacksNon-Hispanic whitesNode-positive diseaseDisparities in care of older adults of color with cancer: A narrative review
Dotan E, Lynch S, Ryan J, Mitchell E. Disparities in care of older adults of color with cancer: A narrative review. Cancer Medicine 2024, 13: e6790. PMID: 38234214, PMCID: PMC10905558, DOI: 10.1002/cam4.6790.Peer-Reviewed Original ResearchSocial determinants of healthOlder adultsGeriatric assessmentDeterminants of healthCancer incidence ratesOlder adults of colorLimited social supportImprove quality of lifeDecreased functional statusQuality of lifeOlder white patientsAge-related challengesPatients of colorAdults of colorSocial determinantsHealthcare accessHealthcare providersOverall careSocial supportPatient careAge-related concernsRacial disparitiesFunctional statusIncidence rateRates of comorbidities