2020
Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua
Silasi M, You Y, Simpson S, Kaislasuo J, Pal L, Guller S, Peng G, Ramhorst R, Grasso E, Etemad S, Durosier S, Aldo P, Mor G. Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua. Scientific Reports 2020, 10: 5785. PMID: 32238853, PMCID: PMC7113245, DOI: 10.1038/s41598-020-62593-9.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinCXCL10 expressionChorionic gonadotropinPotent immune-modulatory effectsImmune system undergoesImmune modulatory effectsEndometrial stromal cellsImmune cell recruitmentMaternal-fetal interfaceImmune regulatory functionsProcess of implantationCD8 cellsCytokine profilePregnancy progressesFetal interfaceDecidual samplesImmune populationsImmune factorsHuman deciduaT cellsDecidual cellsCell recruitmentModulatory effectsEarly hormoneStromal cells
2019
Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies
Lee B, Koeppel AF, Wang ET, Gonzalez TL, Sun T, Kroener L, Lin Y, Joshi NV, Ghadiali T, Turner SD, Rich SS, Farber CR, Rotter JI, Ida Chen YD, Goodarzi MO, Guller S, Harwood B, Serna TB, Williams J, Pisarska MD. Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies. Fertility And Sterility 2019, 111: 535-546. PMID: 30611556, PMCID: PMC7156023, DOI: 10.1016/j.fertnstert.2018.11.005.Peer-Reviewed Original ResearchConceptsFirst trimester placentaSpontaneous pregnancyIVF groupFertility treatmentMaternal medical conditionsTreatment-related factorsAcademic medical centerTranscriptomic profilesGestational age 11Fetal demographicsInfertility groupPregnancy complicationsCohort studySpontaneous conceptionMedical CenterMAIN OUTCOMEMedical conditionsPregnancyDifferent fertility treatmentsIVFLarger studyDifferential gene expressionChorionic villiGene expressionPlacenta