2024
S98 Intratumoral Microbiome Associations With the Infiltration of Natural Killer Cells and Improved Patient Survival in Pancreatic Cancer
Bizyayev D, Merchant A, Segarra D, Montano M, Shahin A, Challa P, Avila C, Al-Zakwani M, Zaman S. S98 Intratumoral Microbiome Associations With the Infiltration of Natural Killer Cells and Improved Patient Survival in Pancreatic Cancer. The American Journal Of Gastroenterology 2024, 119: s71-s71. DOI: 10.14309/01.ajg.0001028760.53866.e7.Peer-Reviewed Original ResearchS1743 Single Cell RNAseq Analysis of Renalase and ATP2B4 expression in Liver Pathology and Tissue Injury
Segarra D, Merchant A, Pascual F, Bizyayev D, Zaman S, Mok S. S1743 Single Cell RNAseq Analysis of Renalase and ATP2B4 expression in Liver Pathology and Tissue Injury. The American Journal Of Gastroenterology 2024, 119: s1263-s1263. DOI: 10.14309/01.ajg.0001036340.55237.5b.Peer-Reviewed Original ResearchChemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival
Zaman S, Gorelick F, Chrobrutskiy A, Chobrutskiy B, Desir G, Blanck G. Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. Oncotarget 2024, 15: 550-561. PMID: 39102218, PMCID: PMC11299663, DOI: 10.18632/oncotarget.28633.Peer-Reviewed Original ResearchConceptsT cell receptorOverall survivalT cellsAssociated with improved overall survivalT-cell receptor CDR3sPromote T cell activationImproved overall survivalSurvival of melanomaPancreatic cancer patientsT cell activationT cell receptor recognitionTumor-residentTumor rejectionMelanoma patientsMelanoma growthMelanoma survivalImmune signature genesSurvival associationsCancer patientsMelanomaSignature genesAmino acid sequenceSurvivalPatientsExpression levelsSu1176 INTRATUMORAL CHLAMYDIA RNA ABUNDANCE IN PANCREATIC ADENOCARCINOMA IS ASSOCIATED WITH IMPROVED SURVIVAL OUTCOMES AND INCREASED INTRATUMORAL MONOCYTE AND NATURAL KILLER CELLS
Al-Zakwani M, Merchant A, Segarra D, Zaman S. Su1176 INTRATUMORAL CHLAMYDIA RNA ABUNDANCE IN PANCREATIC ADENOCARCINOMA IS ASSOCIATED WITH IMPROVED SURVIVAL OUTCOMES AND INCREASED INTRATUMORAL MONOCYTE AND NATURAL KILLER CELLS. Gastroenterology 2024, 166: s-684-s-685. DOI: 10.1016/s0016-5085(24)02031-6.Peer-Reviewed Original ResearchTu1549 INTRATUMORAL SALMONELLA ABUNDANCE IN HEPATOCELLULAR CARCINOMA IS ASSOCIATED WITH INCREASED DENDRITIC CELL INFILTRATE AND IMPROVED SURVIVAL OUTCOMES
Al-Zakwani M, Merchant A, Segarra D, Zaman S. Tu1549 INTRATUMORAL SALMONELLA ABUNDANCE IN HEPATOCELLULAR CARCINOMA IS ASSOCIATED WITH INCREASED DENDRITIC CELL INFILTRATE AND IMPROVED SURVIVAL OUTCOMES. Gastroenterology 2024, 166: s-1725. DOI: 10.1016/s0016-5085(24)04431-7.Peer-Reviewed Original ResearchMo1550 SINGLE CELL RNASEQ ANALYSIS OF FIBROBLAST GROWTH FACTOR RECEPTOR (FGFR) EXPRESSION IN FIBROTIC LIVER PATHOLOGY
Merchant A, Al-Zakwani M, Segarra D, Zaman S. Mo1550 SINGLE CELL RNASEQ ANALYSIS OF FIBROBLAST GROWTH FACTOR RECEPTOR (FGFR) EXPRESSION IN FIBROTIC LIVER PATHOLOGY. Gastroenterology 2024, 166: s-1689. DOI: 10.1016/s0016-5085(24)04344-0.Peer-Reviewed Original ResearchAcute pancreatitis: pathogenesis and emerging therapies
Zaman S, Gorelick F. Acute pancreatitis: pathogenesis and emerging therapies. Journal Of Pancreatology 2024, 7: 10-20. PMID: 38524855, PMCID: PMC10959536, DOI: 10.1097/jp9.0000000000000168.Peer-Reviewed Original ResearchAcute pancreatitisSevere inflammatory disordersLimited treatment optionsLong-term outcomesPotential treatment benefitsPromising new therapyDisease mechanismsPotential therapeutic targetEmerging TherapiesAcute injuryInflammatory disordersPharmacologic interventionsTreatment optionsTreatment benefitPotential therapyNew therapiesSpecific treatmentTherapeutic targetNew treatmentsTherapyPancreatitisTreatmentComplicationsPathogenesisInjury
2023
S1914 Salmonella Abundance Associated with Disease Progression in Stomach Adenocarcinoma and Decreased Intratumoral Natural Killer Cell Infiltrate
Segarra D, Zaman S, Chen G, Mok S. S1914 Salmonella Abundance Associated with Disease Progression in Stomach Adenocarcinoma and Decreased Intratumoral Natural Killer Cell Infiltrate. The American Journal Of Gastroenterology 2023, 118: s1419-s1420. DOI: 10.14309/01.ajg.0000957296.02915.7f.Peer-Reviewed Original ResearchS3 Improved Survival Outcomes in Pancreatic Adenocarcinoma Associated With Intratumoral Bacteroides Abundance and Decreased Regulatory T-Cell Infiltrate
Segarra D, Zaman S, Chen G, Mok S. S3 Improved Survival Outcomes in Pancreatic Adenocarcinoma Associated With Intratumoral Bacteroides Abundance and Decreased Regulatory T-Cell Infiltrate. The American Journal Of Gastroenterology 2023, 118: s2-s3. DOI: 10.14309/01.ajg.0000949652.05104.9b.Peer-Reviewed Original ResearchS457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell Carcinoma
Chen G, Zaman S, McMillan C, Patel A, Segarra D, Protiva P. S457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell Carcinoma. The American Journal Of Gastroenterology 2023, 118: s332-s333. DOI: 10.14309/01.ajg.0000951468.46020.24.Peer-Reviewed Original ResearchMo1223 INCREASED TUMOR RENALASE EXPRESSION IS ASSOCIATED WITH WORSE SURVIVAL OUTCOMES AND CHANGES IN GASTRIC CANCER TUMOR IMMUNITY
Zaman S, Gorelick F. Mo1223 INCREASED TUMOR RENALASE EXPRESSION IS ASSOCIATED WITH WORSE SURVIVAL OUTCOMES AND CHANGES IN GASTRIC CANCER TUMOR IMMUNITY. Gastroenterology 2023, 164: s-790. DOI: 10.1016/s0016-5085(23)02829-9.Peer-Reviewed Original ResearchTu1230 INTRATUMORAL CYTOMEGALOVIRUS RNA SEQUENCES ARE ASSOCIATED WITH POOR SURVIVAL OUTCOMES AND THE UPREGULATION OF INFLAMMATORY PATHWAYS IN COLON ADENOCARCINOMA
Zaman S, Chen G, Segarra D, Patel A, Protiva P. Tu1230 INTRATUMORAL CYTOMEGALOVIRUS RNA SEQUENCES ARE ASSOCIATED WITH POOR SURVIVAL OUTCOMES AND THE UPREGULATION OF INFLAMMATORY PATHWAYS IN COLON ADENOCARCINOMA. Gastroenterology 2023, 164: s-1000. DOI: 10.1016/s0016-5085(23)03324-3.Peer-Reviewed Original ResearchTu1138 INCREASED INTRATUMORAL ALPHAPAPILLOMAVIRUS ABUNDANCE IS ASSOCIATED WITH IMPROVED DISEASE-SPECIFIC SURVIVAL IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Chen G, Zaman S, Segarra D, Patel A, Protiva P. Tu1138 INCREASED INTRATUMORAL ALPHAPAPILLOMAVIRUS ABUNDANCE IS ASSOCIATED WITH IMPROVED DISEASE-SPECIFIC SURVIVAL IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA. Gastroenterology 2023, 164: s-992-s-993. DOI: 10.1016/s0016-5085(23)03295-x.Peer-Reviewed Original ResearchSpecific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers
Zaman S, Chobrutskiy B, Quach J, Blanck G. Specific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers. Journal Of Gastrointestinal Cancer 2023, 54: 1300-1307. PMID: 37103748, DOI: 10.1007/s12029-023-00935-2.Peer-Reviewed Original ResearchConceptsT-cell infiltratesStomach adenocarcinomaGamma delta T cellsCox proportional hazards modelAlimentary tract cancersTumor immune milieuProportional hazards modelPrimary tumor samplesImmune milieuOS probabilityCancer Genome AtlasCell infiltrateTract cancerPatient survivalEsophageal cancerPrimary tumorCancer DatabaseT cellsHazards modelTumor samplesExome filesAlimentary tractGenome AtlasBacterial infiltrationInfiltratesAppendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study
Chen G, Chen K, Sahyoun L, Zaman S, Protiva P. Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study. BMJ Open Gastroenterology 2023, 10: e001045. PMID: 36822658, PMCID: PMC9950880, DOI: 10.1136/bmjgast-2022-001045.Peer-Reviewed Original ResearchConceptsCecal adenocarcinomaAppendiceal adenocarcinomaCox regression analysisAppendiceal cancerMantel-Haenszel log-rank testColorectal cancer screening ratesMultivariable Cox regression analysisCounty-level socioeconomic factorsCancer screening ratesEnd Results (SEER) databaseKaplan-Meier methodRare gastrointestinal malignancyLog-rank testNon-mucinous histologySingle marital statusNon-Hispanic ethnicityYears of ageComparative survival analysisComparative survival studyRegression analysisSAS V.9.4Gastrointestinal malignanciesOverall survivalBetter prognosisChemotherapy protocolsBacterial Sequencing Reads in Blood Exome Files from Melanoma and Cervical Cancer Patients are Associated with Cancer Recurrence
Quach J, Diaz M, Huda T, Kinskey J, Zaman S, Desantis J, Cios K, Blanck G. Bacterial Sequencing Reads in Blood Exome Files from Melanoma and Cervical Cancer Patients are Associated with Cancer Recurrence. Molecular Biotechnology 2023, 65: 1476-1484. PMID: 36653589, DOI: 10.1007/s12033-023-00663-9.Peer-Reviewed Original ResearchConceptsCervical cancer casesCervical cancer patientsCancer patientsExome filesCancer recurrenceCancer casesDisease-free survival probabilityImmunocompromised Cancer PatientsOverall survival resultsCancer clinical outcomesBacterial blood infectionsLower DFSClinical outcomesCervical cancerPrimary tumorSurvival resultsMelanoma casesBlood infectionSolid tumorsGreater riskPatientsBacteroides fragilisBloodPresence of bacteriaBacteroides speciesChemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression
Pakasticali N, Chobrutskiy A, Patel D, Hsiang M, Zaman S, Cios K, Blanck G, Chobrutskiy B. Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression. Cancer Informatics 2023, 22: 11769351231177269. PMID: 37313373, PMCID: PMC10259117, DOI: 10.1177/11769351231177269.Peer-Reviewed Original ResearchCancer-testis antigensCancer antigensBreast cancer antigensT cell receptorGranzyme expressionImmune biomarkersCancer immunotherapyPatient outcomesGranzyme BCandidate antigensTestis antigensAdaptive immune receptorsAntigenCDR3 domainsImmune receptorsTumor gene expression dataReceptorsSurvivalAntigen bindingRegion 3Integration of itemsHigh levelsImmunotherapyBreast cancer datasetExpression correlation
2022
TCR gene segment usage and HLA alleles that are associated with cancer survival rates also represent racial disparities
Angelakakis G, Serraneau K, Barker V, Callahan B, Tong W, Zaman S, Huda T, Blanck G. TCR gene segment usage and HLA alleles that are associated with cancer survival rates also represent racial disparities. International Journal Of Immunogenetics 2022, 50: 41-47. PMID: 36585798, DOI: 10.1111/iji.12610.Peer-Reviewed Original ResearchConceptsTCR gene segment usageHLA allele combinationsGene segment usageCancer outcomesRacial disparitiesSegment usageHLA allelesCertain HLA allelesCancer survival ratesDistinct survival outcomesSocioeconomic factorsDisease courseSurvival outcomesInfectious disease courseSurvival rateAllele combinationsDifferent racial groupsGenetic polymorphismsPrevious pathogen exposurePathogen exposureOutcomesRacial groupsDisparitiesFactorsCancerS220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration
Chen G, Zaman S, Segarra D, Patel A, Protiva P. S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration. The American Journal Of Gastroenterology 2022, 117: e158-e158. DOI: 10.14309/01.ajg.0000857520.28843.4b.Peer-Reviewed Original ResearchS209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival Study
Chen G, Chen K, Rotundo L, Zaman S, Protiva P. S209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival Study. The American Journal Of Gastroenterology 2022, 117: e151-e152. DOI: 10.14309/01.ajg.0000857476.13762.f0.Peer-Reviewed Original Research