2024
Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival
Zaman S, Gorelick F, Chrobrutskiy A, Chobrutskiy B, Desir G, Blanck G. Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. Oncotarget 2024, 15: 550-561. PMID: 39102218, PMCID: PMC11299663, DOI: 10.18632/oncotarget.28633.Peer-Reviewed Original ResearchConceptsT cell receptorOverall survivalT cellsAssociated with improved overall survivalT-cell receptor CDR3sPromote T cell activationImproved overall survivalSurvival of melanomaPancreatic cancer patientsT cell activationT cell receptor recognitionTumor-residentTumor rejectionMelanoma patientsMelanoma growthMelanoma survivalImmune signature genesSurvival associationsCancer patientsMelanomaSignature genesAmino acid sequenceSurvivalPatientsExpression levels
2023
Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study
Chen G, Chen K, Sahyoun L, Zaman S, Protiva P. Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study. BMJ Open Gastroenterology 2023, 10: e001045. PMID: 36822658, PMCID: PMC9950880, DOI: 10.1136/bmjgast-2022-001045.Peer-Reviewed Original ResearchConceptsCecal adenocarcinomaAppendiceal adenocarcinomaCox regression analysisAppendiceal cancerMantel-Haenszel log-rank testColorectal cancer screening ratesMultivariable Cox regression analysisCounty-level socioeconomic factorsCancer screening ratesEnd Results (SEER) databaseKaplan-Meier methodRare gastrointestinal malignancyLog-rank testNon-mucinous histologySingle marital statusNon-Hispanic ethnicityYears of ageComparative survival analysisComparative survival studyRegression analysisSAS V.9.4Gastrointestinal malignanciesOverall survivalBetter prognosisChemotherapy protocols
2022
S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration
Chen G, Zaman S, Segarra D, Patel A, Protiva P. S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration. The American Journal Of Gastroenterology 2022, 117: e158-e158. DOI: 10.14309/01.ajg.0000857520.28843.4b.Peer-Reviewed Original ResearchS208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma
Zaman S, Chen G, Segarra D, Patel A, Protiva P. S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma. The American Journal Of Gastroenterology 2022, 117: e150-e151. DOI: 10.14309/01.ajg.0000857472.84764.69.Peer-Reviewed Original Research
2021
Reconnaissance of tumor immune microenvironment spatial heterogeneity in metastatic renal cell carcinoma and correlation with immunotherapy response
Hajiran A, Chakiryan N, Aydin A, Zemp L, Nguyen J, Laborde J, Chahoud J, Spiess P, Zaman S, Falasiri S, Fournier M, Teer J, Dhillon J, McCarthy S, Moran-Segura C, Katende E, Sexton W, Koomen J, Mulé J, Kim Y, Manley B. Reconnaissance of tumor immune microenvironment spatial heterogeneity in metastatic renal cell carcinoma and correlation with immunotherapy response. Clinical & Experimental Immunology 2021, 204: 96-106. PMID: 33346915, PMCID: PMC7944355, DOI: 10.1111/cei.13567.Peer-Reviewed Original ResearchConceptsMetastatic clear cell renal cell carcinomaClear cell renal cell carcinomaTumor immune microenvironmentRenal cell carcinomaT-betOverall survivalCell carcinomaMetastatic renal cell carcinomaForkhead box protein 3Improved overall survivalCell renal cell carcinomaCox regression analysisImmune cell distributionT-cell markersPoor overall survivalBox protein 3Tumor-stromal interfaceMetastatic tumor samplesPrecision treatment strategiesTumor-stroma interfaceTumor coreImproved survivalImmune markersImmunotherapy responsePoor outcome
2020
Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer
Chobrutskiy A, Chobrutskiy BI, Zaman S, Hsiang M, Blanck G. Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer. Breast Cancer Research And Treatment 2020, 185: 591-600. PMID: 33180235, DOI: 10.1007/s10549-020-05996-6.Peer-Reviewed Original ResearchConceptsOverall survivalBreast cancerPrimary breast cancer patientsGamma delta T cellsBreast cancer tumor tissuesBreast cancer settingProgesterone receptor statusBreast cancer patientsGreater overall survivalPotential antigenic targetsCancer tumor tissuesPatient ageReceptor statusCancer patientsAntigenic targetsCancer settingT cellsSurvival correlationB cellsSurvival rateTumor tissueHigher survival rateImmunogenomic approachesConclusionsThese resultsSurvival parameters