2022
Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment
Gunstad J, Disabato D, Shrestha R, Sanborn V, Mistler CB, Copenhaver MM. Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment. Journal Of Addictive Diseases 2022, 41: 120-127. PMID: 35615880, PMCID: PMC9699904, DOI: 10.1080/10550887.2022.2080626.Peer-Reviewed Original ResearchConceptsLatent profile analysisNeurocognitive dysfunctionBrief inventoryNeuro-cognitive profileNeuro-cognitive impairmentSelf-reported neurocognitive symptomsProfile analysisOpioid-dependent patientsOpioid use disorderTreatment outcomesNeurocognitive impairmentDrug treatment outcomesMultiple domainsTreatment programUse disordersIntervention strategiesIndividual treatment needsNeurocognitive symptomsDrug treatment settingsTreatment settingsMethadone maintenance treatment programAccommodation strategiesModerate concernMaintenance treatment programOptimal treatment outcomes
2020
Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
Copenhaver MM, Sanborn V, Shrestha R, Mistler C, Gunstad J. Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment. Journal Of Addictive Diseases 2020, 39: 166-174. PMID: 33047651, PMCID: PMC11395862, DOI: 10.1080/10550887.2020.1831129.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyDrug treatmentNeurocognitive dysfunctionNeurocognitive impairmentOpioid use disorderPossible clinical utilityAccommodation of patientsNIH ToolboxSubjective cognitive dysfunctionMaintenance therapyObjective cognitive testingSpecific neurocognitive profileTreatment outcomesCognitive dysfunctionClinical utilityUse disordersBrief inventoryObjective test performanceDysfunctionCognitive testingCutoff scoreNeurocognitive profileTest batteryObjective performanceImpairmentAddressing the Challenges of Neurocognitive Impairment (NCI) on Treatment Engagement
Shrestha R, Karki P, Copenhaver M. Addressing the Challenges of Neurocognitive Impairment (NCI) on Treatment Engagement. 2020, 109-140. DOI: 10.1002/9781119129530.ch6.Peer-Reviewed Original Research
2017
Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research
Shrestha R, Altice F, Karki P, Copenhaver M. Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research. Frontiers In Immunology 2017, 8: 561. PMID: 28553295, PMCID: PMC5425476, DOI: 10.3389/fimmu.2017.00561.Peer-Reviewed Original ResearchNeurocognitive impairmentHigh-risk drug usersBehavioral interventionsHigh-risk PWUDHIV prevention behavioral interventionBiobehavioral approachHIV risk reductionHIV prevention interventionsDrug treatment settingsFormative researchHIV prevention effortsTarget populationPrEP adherencePrEP uptakeRisk reduction outcomesHIV preventionDrug treatmentPrevention interventionsFocus groupsTreatment settingsDrug usersRecovery programStructured focus groupsRisk behaviorsTarget population membersAn explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru
Weikum D, Shrestha R, Ferro EG, Vagenas P, Copenhaver M, Spudich S, Alpert MD, Cabello R, Lama JR, Sanchez J, Altice FL. An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru. AIDS Care 2017, 29: 1297-1301. PMID: 28449599, PMCID: PMC6337065, DOI: 10.1080/09540121.2017.1322681.Peer-Reviewed Original ResearchConceptsHIV-positive menNeuropsychological Impairment ScaleNeurocognitive impairmentTransgender womenAntiretroviral therapyHIV-positive MSMPoor clinical outcomeHIV risk behaviorsClinical care settingsHealth-related outcomesExploratory factor analysisART adherenceClinical outcomesPatient populationCare settingsImpairment ScaleRisk behaviorsImpairmentMenPrincipal axis factoringSelf-report scalesOrthogonal varimax rotationWomenBrief self-report scaleOutcomesIntent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis
Shrestha R, Karki P, Huedo-Medina TB, Copenhaver M. Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis. Journal Of The Association Of Nurses In AIDS Care 2017, 28: 612-621. PMID: 28478870, PMCID: PMC7451137, DOI: 10.1016/j.jana.2017.04.005.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsNeurocognitive impairmentRisk behaviorsPreexposure prophylaxisSelf-reported neurocognitive symptomsHigh-risk drug usersHigh-risk PWUDPrEP uptakeNeurocognitive symptomsHIV riskDrug usersSimilar outcomesUnderserved populationsSignificant correlatesProphylaxisImportant unanswered questionsPreliminary evidencePrEPDissemination effortsMediation analysisUnanswered questionsVariables of interestHIVSymptomsCliniciansA Self-report Measure to Detect Neurocognitive Impairment Among Incarcerated People Living with HIV in Malaysian Context: an Exploratory Factor Analysis
Shrestha R, Weikum D, Copenhaver M, Altice FL. A Self-report Measure to Detect Neurocognitive Impairment Among Incarcerated People Living with HIV in Malaysian Context: an Exploratory Factor Analysis. International Journal Of Mental Health And Addiction 2017, 15: 812-825. PMID: 29051714, PMCID: PMC5642920, DOI: 10.1007/s11469-017-9752-0.Peer-Reviewed Original ResearchNeuropsychological Impairment ScaleNeurocognitive impairmentHIV treatment outcomesNeuro-cognitive impairmentExploratory factor analysisSelf-report measuresNeurocognitive symptomsTreatment outcomesTreatment strategiesImpairment ScaleHIVScreening toolImpairmentPLWHEight-factor structureCronbach's alphaPrincipal axis factoringCognitive functioningOrthogonal varimax rotationPsychometric propertiesDrugsPresent studyMale prisonersIncarcerated peopleMore specific formsCorrelates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment
Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Drug And Alcohol Dependence 2017, 173: 107-116. PMID: 28214391, PMCID: PMC5366273, DOI: 10.1016/j.drugalcdep.2016.12.023.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisHIV risk reductionDrug injectionHIV riskRisk behaviorsHigh-risk drug usersHigh-risk PWUDOpioid-dependent personsHIV prevention approachesRecent risk behaviorsCross-sectional studyConsistent condom useHigh-risk behaviorsRisk reductionCorrelates of willingnessPrEP deliveryMethadone treatmentIndependent correlatesMethadone programsSafe drugElevated riskCasual partnersNeurocognitive impairmentDrug usersKey populationsModeling a theory-based approach to examine the influence of neurocognitive impairment on HIV risk reduction behaviors among drug users in treatment
Shrestha R, Huedo-Medina T, Copenhaver M. Modeling a theory-based approach to examine the influence of neurocognitive impairment on HIV risk reduction behaviors among drug users in treatment. Drug And Alcohol Dependence 2017, 171: e190. DOI: 10.1016/j.drugalcdep.2016.08.521.Peer-Reviewed Original Research
2016
Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment
Shrestha R, Huedo-Medina TB, Altice FL, Krishnan A, Copenhaver M. Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment. AIDS And Behavior 2016, 21: 3100-3110. PMID: 28025735, PMCID: PMC5484759, DOI: 10.1007/s10461-016-1637-x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultCell PhoneConnecticutDelivery of Health CareDrug UsersFemaleHIV InfectionsHumansInternetMaleMethadoneNeurocognitive DisordersOpiate Substitution TreatmentPatient Acceptance of Health CarePrevalenceRisk FactorsRisk-TakingSexual BehaviorSmartphoneSubstance Abuse, IntravenousTelemedicineText MessagingConceptsSex-related risk behaviorsNeurocognitive impairmentDrug usersRisk behaviorsHIV-negative drug usersHigh-risk drug usersHigh-risk populationHigh-risk peopleHIV prevention effortsUse of mHealthMethadone clinicsHIV preventionHigh prevalenceMedication remindersHealth programsMHealth acceptancePrevention effortsHealth conditionsMHealth technologiesConvenience sampleDrugsStandardized assessmentReal-world acceptanceMobile healthPhone callsTreatment Engagement Moderates the Effect of Neurocognitive Impairment on Antiretroviral Therapy Adherence in HIV-Infected Drug Users in Treatment
Shrestha R, Karki P, Huedo-Medina TB, Copenhaver M. Treatment Engagement Moderates the Effect of Neurocognitive Impairment on Antiretroviral Therapy Adherence in HIV-Infected Drug Users in Treatment. Journal Of The Association Of Nurses In AIDS Care 2016, 28: 85-94. PMID: 27769735, PMCID: PMC5183513, DOI: 10.1016/j.jana.2016.09.007.Peer-Reviewed Original ResearchThe Influence of Neurocognitive Impairment, Depression, and Alcohol Use Disorders on Health-Related Quality of Life among Incarcerated, HIV-Infected, Opioid Dependent Malaysian Men: A Moderated Mediation Analysis
Shrestha R, Weikum D, Copenhaver M, Altice FL. The Influence of Neurocognitive Impairment, Depression, and Alcohol Use Disorders on Health-Related Quality of Life among Incarcerated, HIV-Infected, Opioid Dependent Malaysian Men: A Moderated Mediation Analysis. AIDS And Behavior 2016, 21: 1070-1081. PMID: 27544515, PMCID: PMC5318281, DOI: 10.1007/s10461-016-1526-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderNeurocognitive impairmentUse disordersMalaysia's largest prisonHealth-related qualityNeuropsychological factorsQuality of lifeLargest prisonHIV-InfectedOpioid dependenceHIV treatmentHRQoLImportant negative predictorMeeting criteriaFuture interventionsDepressionNegative predictorPLWHDisordersMalaysian menStandardized scalesImpairmentMediation analysisHRQoL.HIVModeling a Theory-Based Approach to Examine the Influence of Neurocognitive Impairment on HIV Risk Reduction Behaviors Among Drug Users in Treatment
Huedo-Medina TB, Shrestha R, Copenhaver M. Modeling a Theory-Based Approach to Examine the Influence of Neurocognitive Impairment on HIV Risk Reduction Behaviors Among Drug Users in Treatment. AIDS And Behavior 2016, 20: 1646-1657. PMID: 27052845, PMCID: PMC4945437, DOI: 10.1007/s10461-016-1394-x.Peer-Reviewed Original ResearchConceptsNeurocognitive impairmentCommunity-based methadone maintenance treatmentHIV risk reduction informationSex-related HIV risk behaviorsHIV risk reduction behaviorsHigh-risk PWUDHIV prevention benefitsMethadone maintenance treatmentHIV prevention outcomesOpioid-dependent individualsSignificant neurocognitive impairmentHIV risk behaviorsHIV prevention behaviorsRisk reduction informationHealth behavior changeBehavioral skills modelRisk reduction behaviorsRisk reduction outcomesMaintenance treatmentEfficacious interventionsDrug usersPrevention benefitsPrevention outcomesPrevention behaviorsRisk behaviorsThe Influence of Neurocognitive Impairment on HIV Risk Behaviors and Intervention Outcomes among High-Risk Substance Users: A Systematic Review
Shrestha R, Copenhaver M. The Influence of Neurocognitive Impairment on HIV Risk Behaviors and Intervention Outcomes among High-Risk Substance Users: A Systematic Review. Frontiers In Public Health 2016, 4: 16. PMID: 26904535, PMCID: PMC4746254, DOI: 10.3389/fpubh.2016.00016.Peer-Reviewed Original ResearchHigh-risk substance usersNeurocognitive impairmentIntervention outcomesCognitive impairmentSubstance usersRisk behaviorsCognitive functioningEfficacy of interventionsHIV risk behaviorsSubstance abuseRisk reduction interventionsReciprocal relationshipSystematic reviewImpairmentMedication adherenceInterventionMemoryBehaviorFunctioningAbuseLearningOutcomesSubstantial barriersContextFindingsAn Exploratory Factor Analysis of a Brief Self-Report Scale to Detect Neurocognitive Impairment Among Participants Enrolled in Methadone Maintenance Therapy
Copenhaver M, Shrestha R, Wickersham JA, Weikum D, Altice FL. An Exploratory Factor Analysis of a Brief Self-Report Scale to Detect Neurocognitive Impairment Among Participants Enrolled in Methadone Maintenance Therapy. Journal Of Substance Use And Addiction Treatment 2016, 63: 61-65. PMID: 26879859, PMCID: PMC4775373, DOI: 10.1016/j.jsat.2016.01.002.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyNeuropsychological Impairment ScaleNeurocognitive impairmentMaintenance therapySex-related HIV risk behaviorsHIV risk behaviorsClinical care settingsNeuro-cognitive impairmentExploratory factor analysisCare settingsImpairment ScaleRisk behaviorsAddiction treatmentBrief self-report scaleImpairmentSelf-report measuresSelf-report scalesPatientsPrincipal axis factoringCognitive functioningTherapyFactor analysisOrthogonal varimax rotationPresent studyPotential utility
2015
Gender differences in associations between neurocognitive impairment and cocaine use among high-risk cocaine-dependent methadone-maintained patients
Shrestha R, Huedo-Medina T, Copenhaver M. Gender differences in associations between neurocognitive impairment and cocaine use among high-risk cocaine-dependent methadone-maintained patients. Drug And Alcohol Dependence 2015, 156: e204. DOI: 10.1016/j.drugalcdep.2015.07.549.Peer-Reviewed Original ResearchMethadone-maintained patientsNeurocognitive impairmentCocaine useGender differencesPatientsImpairmentSex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program
Shrestha R, Huedo-Medina TB, Copenhaver MM. Sex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program. Substance Use Research And Treatment 2015, 9: sart.s23332. PMID: 25861219, PMCID: PMC4363005, DOI: 10.4137/sart.s23332.Peer-Reviewed Original ResearchSelf-reported neurocognitive impairmentSex-related differencesAdverse health outcomesNeurocognitive impairmentNeuropsychological Impairment ScaleCocaine usersHealth outcomesTreatment programMethadone maintenance treatment programPossible sex-related differencesMaintenance treatment programSubstance abuse treatmentDifferential treatment outcomesNeuropsychological symptomsPatient awarenessTreatment outcomesImpairment ScaleClinical careHigher scoresPrevention strategiesCocaine cravingConfounding variablesSignificant associationGreater impairmentNeurocognitive deficits