2024
EPCO-26. LONGITUDINAL SINGLE-CELL ANALYSES IDENTIFY DRIVERS OF GENETIC, EPIGENOMIC, AND CELLULAR EVOLUTION IN IDH-MUTANT GLIOMA
Johnson K, Spitzer A, Varn F, Nomura M, Garofano L, Chowdhury T, Anderson K, D’Angelo F, Bussema L, Gritsch S, Oh Y, Moon H, Paek S, Bielle F, Laurenge A, Di Stefano A, Mathon B, Picca A, Sanson M, Lipsa A, Hertel F, Zhao Z, Wang Q, Jiang T, Hermes B, Sanai N, Golebiewska A, Niclou S, Huse J, Yung W, Lasorella A, Suvà M, Iavarone A, Tirosh I, Verhaak R. EPCO-26. LONGITUDINAL SINGLE-CELL ANALYSES IDENTIFY DRIVERS OF GENETIC, EPIGENOMIC, AND CELLULAR EVOLUTION IN IDH-MUTANT GLIOMA. Neuro-Oncology 2024, 26: viii6-viii7. PMCID: PMC11552777, DOI: 10.1093/neuonc/noae165.0025.Peer-Reviewed Original ResearchIDH-mutant gliomasGenetic alterationsStem-like populationDifferentially accessible peaksChromatin accessibility dataCopy number alterationsCellular hierarchyCycling populationTumor microenvironment cell typesSingle nucleus RNA sequencingCell cycle alterationsMalignant cell differentiationHigh tumor gradeNucleus RNA sequencingDNA sequencesATAC sequencingGenetic analysisCellular statesAccessibility peaksMicroenvironment cell typesReduced differentiationRNA sequencingIntratumoral cellular heterogeneityCellular heterogeneityTumor grade
2023
Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort
van Garderen K, Vallentgoed W, Lavrova A, Niers J, de Leng W, Hoogstrate Y, de Heer I, Ylstra B, van Dijk E, Klein S, Draaisma K, Robe P, Verhaak R, Westerman B, French P, van den Bent M, Kouwenhoven M, Kros J, Wesseling P, Smits M. Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort. Neuro-Oncology Advances 2023, 5: vdad149. PMID: 38024241, PMCID: PMC10681663, DOI: 10.1093/noajnl/vdad149.Peer-Reviewed Original ResearchIDH-mutant astrocytomasFluid attenuated inversion recoveryT2-FLAIR mismatchOverall survivalSecond resectionMicrocystic changesT2-FLAIR mismatch signTumor tissueMedian overall survivalGrade 2 tumorsMagnetic resonance imagingSpecific diagnostic markerSurgical resectionFavorable prognosisRecurrent tumorsClinical parametersPrognostic valueFirst resectionHyperintense areasTumor gradeResectionGrade 2AstrocytomasResonance imagingDiagnostic marker