2008
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells
Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nature Genetics 2008, 40: 656-662. PMID: 18408721, PMCID: PMC4167720, DOI: 10.1038/ng.108.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCodon, NonsenseEpidermisGenetic LinkageHaplotypesImmunoglobulinsMiceMice, TransgenicMolecular Sequence DataMultigene FamilyMutationProtein ConformationReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes
2005
The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses
Pennington D, Vermijlen D, Wise E, Clarke S, Tigelaar R, Hayday A. The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses. Advances In Immunology 2005, 87: 27-59. PMID: 16102571, DOI: 10.1016/s0065-2776(05)87002-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesChemokinesCytokinesCytotoxicity, ImmunologicGene Expression ProfilingHumansImmunity, CellularKiller Cells, NaturalMiceModels, ImmunologicalReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesConceptsUnconventional T cellsGene expression analysisConventional T cellsExtensive gene expression analysisT cellsExpression analysisRegulatory functionsCell-mediated immune responsesCell-mediated responsesT cell activityAntigen-specific responsesCellsInflammatory diseasesImmune responseImmunopathology
2003
Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation
Roark C, Aydintug M, Lewis J, Yin X, Lahn M, Hahn Y, Born W, Tigelaar R, O’Brien R. Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation. Journal Of Leukocyte Biology 2003, 75: 68-75. PMID: 14525969, DOI: 10.1189/jlb.0703326.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalEpidermisHybridomasInflammationListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaReference ValuesT-Lymphocyte SubsetsT-LymphocytesConceptsGamma delta T cell subsetT cell subsetsT cell receptorCell subsetsDelta antibodyActivation/memory phenotypeInvariant T cell receptorΓδ T cellsMemory phenotypeInflammatory responseT cellsFlow cytometryCell receptorInflammationMonoclonal antibodiesAntibodiesSelect tissuesCellsTissueSubsetVδ1ThymusThe inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells
Pennington D, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, Tigelaar R, Owen M, Hayday A. The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells. Nature Immunology 2003, 4: 991-998. PMID: 14502287, DOI: 10.1038/ni979.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCyclic AMP Response Element ModulatorDNA-Binding ProteinsFlow CytometryGene Expression ProfilingGenes, T-Cell ReceptorH-Y AntigenMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesConceptsΑβ T cellsConventional αβ T cellsCell developmentFunctional potentialGene profilesT cell receptorT cellsMouse T-cell receptorΓδ T cell developmentT cell developmentT cell progenitorsCell receptorGene expressionCell progenitorsCell populationsImmune responseTCR specificityCellsReceptorsPotential interdependenceProgenitorsExpression
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis
2000
Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice
Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar R, Nomoto K. Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice. The Journal Of Immunology 2000, 165: 3695-3705. PMID: 11034374, DOI: 10.4049/jimmunol.165.7.3695.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell DifferentiationClone CellsCytokinesDendritic CellsEmbryonic and Fetal DevelopmentEpidermal CellsEpidermisFemaleFibroblast Growth Factor 10Fibroblast Growth Factor 7Fibroblast Growth FactorsGene DeletionGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGenes, T-Cell Receptor deltaGenetic MarkersGrowth SubstancesImmunophenotypingMaleMiceMice, Inbred C57BLMice, KnockoutProtein ConformationReceptors, Antigen, T-Cell, gamma-deltaStem CellsThymus GlandT-LymphocytesEnterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches
Laky K, Lefrançois L, Lingenheld E, Ishikawa H, Lewis J, Olson S, Suzuki K, Tigelaar R, Puddington L. Enterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches. Journal Of Experimental Medicine 2000, 191: 1569-1580. PMID: 10790431, PMCID: PMC2213426, DOI: 10.1084/jem.191.9.1569.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDendritic CellsEnterocytesEpidermal CellsEpidermisFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGerminal CenterInterleukin-7Intestine, SmallMiceMice, TransgenicMyelin P2 ProteinNeoplasm ProteinsNerve Tissue ProteinsPeyer's PatchesReceptors, Antigen, T-Cell, gamma-deltaRecombinant Fusion ProteinsTissue DistributionT-LymphocytesTransgenesConceptsTCR-gammadelta cellsIntraepithelial lymphocytesT cell developmentCell developmentPeyer's patchesIL-7Extrathymic T cell developmentΓδ T cellsMucosal lymphoid tissuesGammadelta intraepithelial lymphocytesIL-7 expressionT cell receptorB cell maturationIntestinal fatty acidExtrathymic developmentLymphoid tissueT cellsIntestinal mucosaEnterocyte expressionBone marrowProtein promoterIntestinal epitheliumCell maturationCell receptorMice
1998
Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary Vγ Gene Usage
Mallick-Wood C, Lewis J, Richie L, Owen M, Tigelaar R, Hayday A. Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary Vγ Gene Usage. Science 1998, 279: 1729-1733. PMID: 9497293, DOI: 10.1126/science.279.5357.1729.Peer-Reviewed Original ResearchConceptsGene segmentsVariable region gene segmentsRegion gene segmentsParticular gene segmentsReceptor conformationTCR chainsReceptor gammaAssociation of expressionAlphabeta T cellsCellsConservationT-cell receptor gammaConformational determinantsGammadelta T cell subsetsGene usageT cellsConformationΓδ cellsB cellsLymphocyte repertoireVgamma5SitesDendritic epidermal T cellsExpressionRepertoire
1996
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Mallick-Wood C, Pao W, Cheng A, Lewis J, Kulkarni S, Bolen J, Rowley B, Tigelaar R, Pawson T, Hayday A. Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9704-9709. PMID: 8790395, PMCID: PMC38493, DOI: 10.1073/pnas.93.18.9704.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsElectrophoresis, Polyacrylamide GelEnzyme PrecursorsEpithelial CellsEpitheliumFlow CytometryIntracellular Signaling Peptides and ProteinsLymphocytesMiceMutagenesis, Site-DirectedPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthProtein-Tyrosine KinasesReceptors, Antigen, T-Cell, gamma-deltaSyk KinaseConceptsGamma delta T cellsDelta T cellsIntraepithelial gamma delta T cellsT cellsSplenic gamma delta T cellsSyk tyrosine kinaseGamma delta T cell repertoireGene rearrangementsT cell repertoireReceptor gene rearrangementsSyk-deficient miceDelta gene rearrangementsAntigen receptor gene rearrangementsTyrosine kinaseSyk deficiencyCell repertoireB cellsChimeric miceMiceSpecific epitheliaCellsLymphocytesSubstantial depletionCharacteristic associationsDevelopmental arrest
1995
Murine epidermal V gamma 5/V delta 1-T-cell receptor+ T cells respond to B-cell lines and lipopolysaccharides.
Reardon C, Heyborne K, Tsuji M, Zavala F, Tigelaar R, O'Brien R, Born W. Murine epidermal V gamma 5/V delta 1-T-cell receptor+ T cells respond to B-cell lines and lipopolysaccharides. Journal Of Investigative Dermatology 1995, 105: 58s-61s. PMID: 7615998, DOI: 10.1111/1523-1747.ep12316074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell LineCytokinesEpidermal CellsEpidermisLipopolysaccharidesMiceMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesConceptsB cell linesColony-stimulating factorCytokine productionGamma deltaGamma delta T cell linesGranulocyte-macrophage colony-stimulating factorT cell clonesB-cell lymphomaAbsence of lipopolysaccharideT cell stimulationMacrophage colony-stimulating factorCell linesT cell receptorT cell linesIL-10C57BL/6 miceB lymphoma cell lineIL-6IL-8IL-2IL-4IL-5Tumor necrosisT cellsHuman B lymphoma cell line
1992
Expression of mouse Tla region class I genes in tissue enriched for γδ cells
Eghtesady P, Brorson K, Cheroutre H, Tigelaar R, Hood L, Kronenberg M. Expression of mouse Tla region class I genes in tissue enriched for γδ cells. Immunogenetics 1992, 36: 377-388. PMID: 1388139, DOI: 10.1007/bf00218045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBase SequenceBlotting, NorthernDNA ProbesFetusGene ExpressionGenes, MHC Class IMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataMultigene FamilyPolymerase Chain ReactionReceptors, Antigen, T-Cell, gamma-deltaRepetitive Sequences, Nucleic AcidT-LymphocytesConceptsΓδ T cellsT cellsPolymerase chain reactionTla region genesClass IΓδ T lymphocytesPresentation of antigensThymus leukemia antigenMajor histocompatibility complexRegion gene productsΓδ cellsLeukemia antigenAntigen presentationT lymphocytesRegion genesFetal tissuesTL antigensMouse major histocompatibility complexMonoclonal antibodiesHistocompatibility complexPattern of expressionAntigenChain reactionRecent evidenceNorthern blot analysisT Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin
Modlin R, Lewis J, Uyemura K, Tigelaar R. T Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin. Chemical Immunology And Allergy 1992, 53: 61-74. PMID: 1534236, DOI: 10.1159/000319103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAnimalsDendritic CellsDermatitis, ContactHeat-Shock ProteinsHumansLeprosyMiceReceptors, Antigen, T-Cell, gamma-deltaSkinT-Lymphocyte SubsetsT-Lymphocytes
1991
Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene
Kuziel W, Lewis J, Nixon‐Fulton J, Tigelaar R, Tucker P. Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene. European Journal Of Immunology 1991, 21: 1563-1566. PMID: 1828429, DOI: 10.1002/eji.1830210635.Peer-Reviewed Original ResearchConceptsAntibody-dependent cellular cytotoxicityNatural killer cellsT cellsKiller cellsCellular cytotoxicityReceptor IITcR gamma/delta T cellsGamma/delta T cellsLectin-dependent cellular cytotoxicityShort-term bulk culturesHuman natural killer cellsMouse natural killer (NK) cellsLong-term clonesR alphaEpidermal T cellsDelta T cellsFcγ receptor IIFc gamma receptor IIFc gamma RIICD16 expressionGamma RIIBulk culturesCell populationsNorthern blot analysisBlot analysis
1990
TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue
Tigelaar R, Lewis J, Bergstresser P. TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue. Journal Of Investigative Dermatology 1990, 94: s58-s63. PMID: 1972173, DOI: 10.1111/1523-1747.ep12875138.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsGamma/delta cellsT cell antigen receptorEpidermal T cellsT cellsCD4-CD8Alpha/beta T cell antigen receptorGamma/delta typeSkin-Associated Lymphoid TissueBone marrow-derived cellsGamma/delta populationsClass II MHC moleculesDelta cellsMarrow-derived cellsTCR junctional regionsEarly fetal thymocytesMHC-like moleculesLangerhans cellsLymphoid tissueTCR heterogeneityNormal miceMHC moleculesThy-1Fetal thymocytesMHC type
1988
γδ Antigen receptors of Thy-1 + dendritic epidermal cells: Implications for thymic differentiation
Allison J, Hayran W, Asarnow D, Tigelaar R, Tucker P, Bonyhadi M. γδ Antigen receptors of Thy-1 + dendritic epidermal cells: Implications for thymic differentiation. Immunologic Research 1988, 7: 292. PMID: 2906352, DOI: 10.1007/bf02935534.Peer-Reviewed Original ResearchAnimalsAntigens, Differentiation, T-LymphocyteAntigens, SurfaceBase SequenceCD3 ComplexCell DifferentiationDendritic CellsDNAGene Expression RegulationGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGene Rearrangement, T-LymphocyteMiceReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaThy-1 AntigensT-LymphocytesLimited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells
Asarnow D, Kuziel W, Bonyhad M, Tigelaar R, Tucker P, Allison J. Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells. Cell 1988, 55: 837-847. PMID: 2847872, DOI: 10.1016/0092-8674(88)90139-0.Peer-Reviewed Original ResearchConceptsT cellsGamma delta antigen receptorsDendritic epidermal cellsPeripheral lymphoid tissuesAdult T-cellEarly fetal thymusLymphoid tissueImmune surveillanceFetal thymusFetal thymocytesThy-1Antigen receptorCell clonesAlpha betaReceptor geneAntigen receptor genesMinor populationDelta gene segmentsReceptorsMajor populationCellsDelta geneStriking homogeneityGene segmentsCertain epithelia
1987
Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells
Kuziel W, Takashima A, Bonyhadi M, Bergstresser P, Allison J, Tigelaar R, Tucker P. Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature 1987, 328: 263-266. PMID: 2885757, DOI: 10.1038/328263a0.Peer-Reviewed Original ResearchConceptsEpidermal cellsT cell receptorDendritic epidermal cellsThy-1Steady-state levelsMurine Thy-1T lymphocytesCell differentiationT-cell lineageT cell differentiationDistinct populationsMost T lymphocytesRNA expressionMajor histocompatibility complexΔ complexNecessary eventΑ-chainΓ-chainMinor populationDendritic cellsLangerhans cellsExpressionCellsNormal miceHistocompatibility complex