2016
Increased susceptibility of Cftr−/− mice to LPS-induced lung remodeling
Bruscia E, Zhang P, Barone C, Scholte BJ, Homer R, Krause D, Egan ME. Increased susceptibility of Cftr−/− mice to LPS-induced lung remodeling. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2016, 310: l711-l719. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.Peer-Reviewed Original ResearchConceptsLung pathologyCF miceImmune responseWT miceChronic inflammationCystic fibrosisAbnormal immune responseChronic pulmonary infectionPersistent immune responseWild-type littermatesCF mouse modelsPseudomonas aeruginosa lipopolysaccharideCF lung pathologyPulmonary infectionChronic administrationLPS exposurePersistent inflammationLung remodelingWT littermatesLung tissueOverall pathologyMouse modelInflammationChronic exposureBacterial products
2012
Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9
Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-4176. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/iai.00417-12.Peer-Reviewed Original ResearchConceptsC3H/HeN miceCBA/J miceHeN micePulmonary infectionJ miceFungal burdenSusceptible C3H/HeN miceInterleukin-5Cryptococcus neoformans Pulmonary InfectionIL-13 protein expressionHigher pulmonary expressionLung fungal burdenGoblet cell metaplasiaTh2 immune responsePathogenesis of pneumoniaIL-17 proteinCBA/JCryptococcal pneumoniaGreater airwayTissue neutrophiliaCryptococcal infectionCell metaplasiaIntratracheal infectionPulmonary inflammationTissue eosinophilia