2000
Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures
Cohen R, Carson R, Saunders R, Doudet D. Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures. Brain Research 2000, 879: 1-6. PMID: 11010998, DOI: 10.1016/s0006-8993(00)02528-2.Peer-Reviewed Original ResearchConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityAnterior commissureCorpus callosumKappa-opiate receptor antagonistUnilateral optic tract lesionRhesus monkeysOptic tract lesionsBrain functional activitySplit animalsIpsilateral changesOptic tractTract lesionsUnilateral lesioningPosterior putamenReceptor antagonistHealthy monkeysLateral cortexOccipital cortexMedial cortexVisual deprivationEmission tomographyTransectionCommissure
1999
Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
Cohen R, Carson R, Wyatt R, Doudet D. Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP. Synapse 1999, 33: 282-288. PMID: 10421709, DOI: 10.1002/(sici)1098-2396(19990915)33:4<282::aid-syn5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBasal GangliaBrainCerebellumCerebral CortexDihydroxyphenylalanineFluorine RadioisotopesFunctional LateralityInfusions, ParenteralLimbic SystemMacaca mulattaNaltrexoneNarcotic AntagonistsOrgan SpecificityReceptors, OpioidReceptors, Opioid, kappaReceptors, Opioid, muTomography, Emission-ComputedConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityKappa-opiate receptor antagonistInitial clinical manifestationBasal ganglia functionBasal ganglia circuitsParkinsonian animalsParkinsonian symptomsAnterior putamenClinical manifestationsDopamine innervationGanglia functionReceptor antagonistInternal carotidGanglia circuitsTreatment responsivenessOpiate pathwaysParkinson's diseaseNormal controlsMild lossEmission tomographyRhesus monkeysPET studiesMPTP
1997
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.
Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997, 120: 1173-1197. PMID: 9236630, DOI: 10.1093/brain/120.7.1173.Peer-Reviewed Original ResearchConceptsSlow-wave sleepSleep-wake cycleHeteromodal association areasREM sleepBasal gangliaSensory cortexState-dependent changesAssociation cortexAssociation areasRegional cerebral blood flowRapid eye movement (REM) sleepActivity of limbicMesial temporal cortexCerebral blood flowEye movement sleepSecondary sensory cortexNormal male volunteersCharacteristics of sleepHeteromodal association cortexFrontoparietal association cortexUnimodal sensory areasREM sleep stateStages of sleepStatistical parametric mappingCentrencephalic structures
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samples