2021
In vivo evidence of lower synaptic vesicle density in schizophrenia
Radhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D’Souza D. In vivo evidence of lower synaptic vesicle density in schizophrenia. Molecular Psychiatry 2021, 26: 7690-7698. PMID: 34135473, DOI: 10.1038/s41380-021-01184-0.Peer-Reviewed Original ResearchConceptsSynaptic vesicle densityHealthy controlsVesicle densityHigh-resolution research tomographySynaptic densitySCZ patientsVivo measuresNovel positron emission tomography (PET) ligandGender-matched healthy controlsCumulative antipsychotic exposurePositron emission tomography (PET) ligandSynaptic spine densityPsychosis symptom severityGray matter volumeJ bindingAntipsychotic exposureSpine densityDisease progressionFrontal cortexOccipital cortexTomography ligandTemporal cortexAnterior cingulateVivo findingsParietal cortex
2019
Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain
Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.Peer-Reviewed Original ResearchConceptsTest-retest variabilityNondisplaceable distribution volumeOccipital cortexEnzyme 11β-hydroxysteroid dehydrogenase type 1White matterDistribution volumeTreatment of depressionDehydrogenase type 1Large cortical regionsPosttraumatic stress disorderHuman brainAdditional scansIntraclass correlation coefficientAge-related cognitive functionBolus administrationFrontal cortexCaudate nucleusAdipose tissueTime-activity curvesNovel radiotracersGlucocorticoid levelsParietal cortexCortical regionsPattern of uptakeType 1
2000
PET evaluation of [18F]FCWAY, an analog of the 5-HT1A receptor antagonist, WAY-100635
Carson R, Lang L, Watabe H, Der M, Adams H, Jagoda E, Herscovitch P, Eckelman W. PET evaluation of [18F]FCWAY, an analog of the 5-HT1A receptor antagonist, WAY-100635. Nuclear Medicine And Biology 2000, 27: 493-497. PMID: 10962257, DOI: 10.1016/s0969-8051(00)00118-9.Peer-Reviewed Original Research
1995
Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study
Berman K, Ostrem J, Randolph C, Gold J, Goldberg T, Coppola R, Carson R, Herscovitch P, Weinberger D. Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study. Neuropsychologia 1995, 33: 1027-1046. PMID: 8524452, DOI: 10.1016/0028-3932(95)00035-2.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestDorsolateral prefrontal cortexCard Sorting TestSorting TestSensorimotor control taskPhysiological activationInferior parietal lobuleInferior temporal cortexCognitive operationsPrefrontal lesionsMemory componentsNeuropsychological testsVisual associationParietal lobulePositron emission tomographyPrefrontal cortexNeural circuitryControl taskCortical networksTemporal cortexWCST activationExperiential phenomenaFrontal cortexPositron emission tomography studyRegional cerebral blood flow
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samples