2022
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Bini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo. Methods In Molecular Biology 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBeta-cell massFunctional beta-cell massDopamine D2/D3 receptorsD2/D3 receptorsBeta-cell lossType 2 diabetesEfficacy of therapeuticsQuantitative positron emission tomographyInsulin secretionDopamine receptorsD3 receptorsGlucose regulationPET radioligandEmission tomographyType 1Clinical usePET imagingReceptorsQuantitative PET imagingVMAT2Cellular transportersImagingVivoQuantitative imaging
1997
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier A, Su T, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2569-2574. PMID: 9122236, PMCID: PMC20129, DOI: 10.1073/pnas.94.6.2569.Peer-Reviewed Original ResearchConceptsSynaptic dopamine concentrationsDopamine concentrationsDopamine outflowDopamine levelsStriatal extracellular dopamine levelsBinding reductionPositron emission tomography radioligandExtracellular dopamine levelsSynaptic dopamine levelsAmphetamine-induced changesNonhuman primate studiesPositron emission tomography (PET) methodDopamine overactivityPatients elevationNovel brain imaging methodVivo microdialysisAmphetamine doseDopamine receptorsClinical studiesDopamine releasePreclinical studiesHealthy volunteersBrain imaging methodsDopamine increasesTomography radioligand