2021
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
Ghovanloo MR, Ruben PC. Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications. The Neuroscientist 2021, 28: 318-334. PMID: 34027742, PMCID: PMC9344566, DOI: 10.1177/10738584211017009.Peer-Reviewed Original ResearchConceptsClinical implicationsNav channelsPotential therapeutic meansInteractions of cannabidiolVoltage-gated sodiumSodium channel pharmacologyClinical syndromePreclinical studiesCBD useNeurological conditionsCBD interactionsChannel pharmacologyTherapeutic meansAction potentialsMuscular problemsPathophysiological conditionsCannabidiolChannel functionExcitable tissuesViable compoundCannabis plantTissueDifferent tissuesHyperexcitabilitySyndrome
2018
A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports 2018, 8: 6304. PMID: 29674667, PMCID: PMC5908869, DOI: 10.1038/s41598-018-24719-y.Peer-Reviewed Original ResearchConceptsPeriodic paralysisSkeletal muscle voltageSkeletal muscle channelopathiesHypokalemic periodic paralysisSteady-state fast inactivationLow potassium levelsAutosomal dominant mutationsEpisodic attacksIntense exercisePhysical activityMuscle channelopathiesBlood acidosisCommon triggerPotassium levelsAction potential modelingParalysisSodium channelsMuscular contractionSkeletal muscleMyotoniaPhenotype correlationLate currentPatientsExtracellular pHFast inactivation
2016
Chapter Fifteen Physiology and Pathophysiology of Sodium Channel Inactivation
Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Chapter Fifteen Physiology and Pathophysiology of Sodium Channel Inactivation. Current Topics In Membranes 2016, 78: 479-509. PMID: 27586293, DOI: 10.1016/bs.ctm.2016.04.001.Peer-Reviewed Original Research