2022
Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
Ghovanloo MR, Goodchild SJ, Ruben PC. Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study. PLOS ONE 2022, 17: e0271801. PMID: 35913948, PMCID: PMC9342711, DOI: 10.1371/journal.pone.0271801.Peer-Reviewed Original ResearchConceptsHuman embryonic kidney cellsEmbryonic kidney cellsHEK cell membranesMembrane biophysical propertiesKidney cellsMonomeric proteinCompound-protein interactionsBacterial cellsIon channelsCell membraneBiophysical propertiesLipid membranesFormation of poresCellsLinear gramicidinCannabis plantCBD activityMembraneGramicidinPlantsProteinPotential therapeutic properties
2020
Cannabidiol interactions with voltage-gated sodium channels
Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace B. Cannabidiol interactions with voltage-gated sodium channels. ELife 2020, 9: e58593. PMID: 33089780, PMCID: PMC7641581, DOI: 10.7554/elife.58593.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsNavMs voltage-gated sodium channelHigh-resolution X-ray crystallographyIon translocation pathwaySodium channelsCentral hydrophobic cavitySodium channel mutationsTranslocation pathwayMolecular mechanismsNovel siteNovel insightsTRPV2 channelsTarget siteChannel mutationsX-ray crystallographyNon-psychoactive compoundFunctional effectsHydrophobic cavityCannabis plantChannel inhibitionSitesPlantsMutationsNeurological diseasesType of epilepsy