2022
Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes
Fouda MA, Ghovanloo M, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal Of Physiology 2022, 600: 2835-2851. PMID: 35436004, DOI: 10.1113/jp282768.Peer-Reviewed Original ResearchConceptsLate sodium currentSodium currentSkeletal muscleAction potential durationRepetitive action potentialsVoltage-gated sodium channelsSeizure disorderTrigger seizuresPeripheral nervesPotential durationSodium channelopathiesAction potentialsSodium channelsChannel inactivationPainDysfunctionMyotoniaMuscleHeartGating propertiesNerveSeizuresArrhythmiasChannelopathiesDisease
2018
A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports 2018, 8: 6304. PMID: 29674667, PMCID: PMC5908869, DOI: 10.1038/s41598-018-24719-y.Peer-Reviewed Original ResearchConceptsPeriodic paralysisSkeletal muscle voltageSkeletal muscle channelopathiesHypokalemic periodic paralysisSteady-state fast inactivationLow potassium levelsAutosomal dominant mutationsEpisodic attacksIntense exercisePhysical activityMuscle channelopathiesBlood acidosisCommon triggerPotassium levelsAction potential modelingParalysisSodium channelsMuscular contractionSkeletal muscleMyotoniaPhenotype correlationLate currentPatientsExtracellular pHFast inactivation