2022
Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
Ghovanloo MR, Goodchild SJ, Ruben PC. Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study. PLOS ONE 2022, 17: e0271801. PMID: 35913948, PMCID: PMC9342711, DOI: 10.1371/journal.pone.0271801.Peer-Reviewed Original ResearchConceptsHuman embryonic kidney cellsEmbryonic kidney cellsHEK cell membranesMembrane biophysical propertiesKidney cellsMonomeric proteinCompound-protein interactionsBacterial cellsIon channelsCell membraneBiophysical propertiesLipid membranesFormation of poresCellsLinear gramicidinCannabis plantCBD activityMembraneGramicidinPlantsProteinPotential therapeutic properties
2021
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
Ghovanloo MR, Ruben PC. Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications. The Neuroscientist 2021, 28: 318-334. PMID: 34027742, PMCID: PMC9344566, DOI: 10.1177/10738584211017009.Peer-Reviewed Original ResearchConceptsClinical implicationsNav channelsPotential therapeutic meansInteractions of cannabidiolVoltage-gated sodiumSodium channel pharmacologyClinical syndromePreclinical studiesCBD useNeurological conditionsCBD interactionsChannel pharmacologyTherapeutic meansAction potentialsMuscular problemsPathophysiological conditionsCannabidiolChannel functionExcitable tissuesViable compoundCannabis plantTissueDifferent tissuesHyperexcitabilitySyndrome
2020
Cannabidiol interactions with voltage-gated sodium channels
Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace B. Cannabidiol interactions with voltage-gated sodium channels. ELife 2020, 9: e58593. PMID: 33089780, PMCID: PMC7641581, DOI: 10.7554/elife.58593.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsNavMs voltage-gated sodium channelHigh-resolution X-ray crystallographyIon translocation pathwaySodium channelsCentral hydrophobic cavitySodium channel mutationsTranslocation pathwayMolecular mechanismsNovel siteNovel insightsTRPV2 channelsTarget siteChannel mutationsX-ray crystallographyNon-psychoactive compoundFunctional effectsHydrophobic cavityCannabis plantChannel inhibitionSitesPlantsMutationsNeurological diseasesType of epilepsy