2022
Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise
Brícola R, Cordeiro A, Crisol B, Braga R, de Melo D, Rocha M, Gaspar R, Nakandakari S, Silva V, Anaruma C, Katashima C, Canciglieri R, Munõz V, Pavan I, Pinto A, Simabuco F, da Silva A, Moura L, Pauli J, Cintra D, Ropelle E. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise. Cell Biochemistry And Function 2022, 41: 128-137. PMID: 36515301, DOI: 10.1002/cbf.3770.Peer-Reviewed Original ResearchConceptsAged miceAdipose tissueControl of lipolysisHigh-intensity interval trainingSubcutaneous white adipose tissueExperimental mouse modelAdipose tissue metabolismWhite adipose tissueMessenger RNA levelsInterval trainingMouse modelTissue metabolismLipolytic pathwayMiceRNA levelsProtein levelsScWATTranscriptomic analyzesReversal effectTissueExerciseSignificant hallmarkLipolysisABHD5Lipolytic activity
2020
Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats
Minuzzi L, da Conceição L, Muñoz V, Vieira R, Gaspar R, da Silva A, Cintra D, Pereira de Moura L, Ropelle E, Teixeira A, Pauli J. Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats. Cytokine 2020, 137: 155306. PMID: 33010727, DOI: 10.1016/j.cyto.2020.155306.Peer-Reviewed Original ResearchConceptsAerobic physical trainingInsulin sensitivityIL-15Physical trainingGlucose toleranceInterleukin-15Elderly ratsWhole-body insulin sensitivityShort-term physical trainingSkeletal muscleLast exercise sessionExercise training protocolMesenteric fat massPhysical exercise trainingPhysical exercise protocolSkeletal muscle alterationsFourteen Wistar ratsExpression of HIF1αExercise trainingExercise protocolExercise sessionsMuscle alterationsFat massWistar ratsSupraphysiological levelsAging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats
Gaspar R, Muñoz V, Nakandakari S, Vieira R, da Conceição L, de Oliveira F, Crisol B, da Silva A, Cintra D, de Moura L, Ropelle E, Zaghloul I, Mekary R, Pauli J. Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats. Experimental Gerontology 2020, 139: 111021. PMID: 32659331, DOI: 10.1016/j.exger.2020.111021.Peer-Reviewed Original ResearchConceptsER stressEukaryotic translation initiation factorProtein kinase RNA-like endoplasmic reticulum kinaseRNA-like endoplasmic reticulum kinaseTranslation initiation factorPhosphorylation of inositolStress response regulationEndoplasmic reticulum kinaseEndoplasmic reticulum stress pathwayMammalian homologDrosophila tribblesEndoplasmic reticulum stressInitiation factorsProtein contentTRB3Multiple tissuesStress pathwaysImmunoglobulin proteinEnzymes of gluconeogenesisReticulum stressHepatic glucose productionEnzyme 1Response regulationMolecular changesPyruvate challenge
2018
The Effects of Aging on Rho-Kinase and Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Rats
Muñoz V, Gaspar R, Kuga G, Pavan I, Simabuco F, da Silva A, de Moura L, Cintra D, Ropelle E, Pauli J. The Effects of Aging on Rho-Kinase and Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Rats. The Journals Of Gerontology Series A 2018, 75: 432-436. PMID: 30596894, DOI: 10.1093/gerona/gly293.Peer-Reviewed Original ResearchThe reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle
Canciglieri P, Kuga G, Muñoz V, Gaspar R, da Rocha A, Breda L, Anaruma C, Minuzzi L, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. Life Sciences 2018, 210: 209-213. PMID: 30189216, DOI: 10.1016/j.lfs.2018.09.006.Peer-Reviewed Original ResearchConceptsExercise training protocolFischer 344 ratsPhysical exerciseOld ratsShort-term exercise trainingNon-pharmacological therapeutic interventionsSkeletal muscleTraining protocolPossible therapeutic effectsAdiponectin receptor 1Old Fischer 344 ratsAge-related increaseGlucose intoleranceExercise trainingGlucose toleranceAdiponectin signalingTherapeutic effectTherapeutic interventionsAge-related deficitsReceptor 1RatsAkt phosphorylationReversal effectExerciseIsoform 1Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B
Kuga G, Muñoz V, Gaspar R, Nakandakari S, da Silva A, Botezelli J, Leme J, Gomes R, de Moura L, Cintra D, Ropelle E, Pauli J. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental Gerontology 2018, 104: 66-71. PMID: 29421605, DOI: 10.1016/j.exger.2018.02.005.Peer-Reviewed Original ResearchConceptsMiddle-aged ratsBrain-derived neurotrophic factorΒ-amyloid contentAlzheimer's diseaseInsulin resistanceTau phosphorylationMorris water maze testMiddle-aged Wistar ratsInsulin tolerance testMain risk factorsAge-related changesNeurotrophic factorTolerance testRisk factorsMaze testImpaired insulinWistar ratsNew therapiesHippocampus regionBody weightCognitive declineRole of PTP1BSynaptic plasticityRatsSpatial learning