2023
Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
Leitner B, Lee W, Zhu W, Zhang X, Gaspar R, Li Z, Rabinowitz J, Perry R. Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis. PLOS ONE 2023, 18: e0286525. PMID: 37410734, PMCID: PMC10325078, DOI: 10.1371/journal.pone.0286525.Peer-Reviewed Original ResearchConceptsTCA cycle anaplerosisGlobal mitochondrial dysfunctionAromatic amino acid transportAmino acid transportTissue-specific metabolic responsesMurine polymicrobial sepsis modelMetabolic signaturesAntioxidant metabolismGlutathione biosynthesisMitochondrial metabolismTCA cycleGreat therapeutic interestEnergetic demandsPolymicrobial sepsis modelAntioxidant synthesisUnique metabolic signatureGlutamine metabolismMitochondrial dysfunctionAcid transportMuscle transcriptomicsGlutathione cyclingATP ratioIsotope tracingCritical illnessReduced expression
2019
NAD+ precursor increases aerobic performance in mice
Crisol B, Veiga C, Braga R, Lenhare L, Baptista I, Gaspar R, Muñoz V, Cordeiro A, da Silva A, Cintra D, Moura L, Pauli J, Ropelle E. NAD+ precursor increases aerobic performance in mice. European Journal Of Nutrition 2019, 59: 2427-2437. PMID: 31494696, DOI: 10.1007/s00394-019-02089-z.Peer-Reviewed Original ResearchConceptsNR supplementationSkeletal muscleMitochondrial markersMitochondrial proteinsTranscriptomic analysisRate-limiting enzymePhysiological assaysMitochondrial metabolismMitochondrial biogenesisMitochondrial oxidative capacityBXD miceIsogenic strainsDifferent phenotypesProtein contentMolecular assaysAerobic performanceOxidative capacityMuscle metabolismMetabolismBiogenesisMTCO1AssaysLarge panelBiosynthesisGenes