2022
Short-term physical exercise controls age-related hyperinsulinemia and improves hepatic metabolism in aged rodents
Muñoz V, Gaspar R, Mancini M, de Lima R, Vieira R, Crisol B, Antunes G, Trombeta J, Bonfante I, Simabuco F, da Silva A, Cavaglieri C, Ropelle E, Cintra D, Pauli J. Short-term physical exercise controls age-related hyperinsulinemia and improves hepatic metabolism in aged rodents. Journal Of Endocrinological Investigation 2022, 46: 815-827. PMID: 36318449, DOI: 10.1007/s40618-022-01947-8.Peer-Reviewed Original ResearchConceptsInsulin sensitivityHepatic metabolismPhysical exerciseInsulin resistanceAerobic exerciseMetabolic healthAged rodentsShort-term aerobic exerciseAge-related insulin resistanceShort-term exercise trainingSignificant metabolic impairmentType 2 diabetesHepatic fat accumulationWhole-body glucoseDevelopment/progressionHepatic fat metabolismExercise trainingGlucose toleranceInsulin secretionFat accumulationHigh prevalenceHyperinsulinemic ratsMetabolic impairmentElderly populationGlucose homeostasis
2020
Long-term effects of moderate physical exercise during early childhood on insulin sensitivity in rats during adulthood
Pereira R, Muñoz V, Anaruma C, Gaspar R, Gaspar R, Ropelle E, Cintra D, da Silva A, Pauli J, de Moura L. Long-term effects of moderate physical exercise during early childhood on insulin sensitivity in rats during adulthood. Revista Brasileira De Educação Física E Esporte 2020, 34: 227-236. DOI: 10.11606/1807-5509202000020227.Peer-Reviewed Original ResearchModerate physical exerciseInsulin sensitivityPhysical exerciseGlycogen storesLipogenic activityGlucose uptakePancreatic insulin levelsDays/weekLower body weight gainPhysical exercise protocolBody weight gainHours/dayDays of ageHOMA-IRInsulin levelsInsulin resistanceMetabolic healthExercise protocolSwimming exerciseWistar ratsLong-term effectsBody fatPancreatic insulinAdipose tissueAnaerobic threshold