2024
The Hierarchical Taxonomy of Psychopathology and the Search for Neurobiological Substrates of Mental Illness: A Systematic Review and Roadmap for Future Research
DeYoung C, Blain S, Latzman R, Grazioplene R, Haltigan J, Kotov R, Michelini G, Venables N, Docherty A, Goghari V, Kallen A, Martin E, Palumbo I, Patrick C, Perkins E, Shackman A, Snyder M, Tobin K. The Hierarchical Taxonomy of Psychopathology and the Search for Neurobiological Substrates of Mental Illness: A Systematic Review and Roadmap for Future Research. Journal Of Psychopathology And Clinical Science 2024, 133: 697-715. PMID: 39480338, PMCID: PMC11529694, DOI: 10.1037/abn0000903.Peer-Reviewed Original ResearchConceptsHierarchical Taxonomy of PsychopathologyTaxonomy of PsychopathologyClinical neuroscience researchHierarchical taxonomyNeuroscience researchAddictions Neuroclinical AssessmentDimensions of psychopathologyResearch Domain CriteriaDepressive symptom dimensionsHuman neuroimaging studiesTraditional psychiatric diagnosesDistress subfactorTransdiagnostic frameworkNeuroclinical AssessmentSymptom dimensionsCategorical nosologyNeurobiological substratesNeurobiological mechanismsNeuroimaging studiesPsychiatric diagnosisHiTOPInternalizing spectrumAssessment batteryPsychopathologyMental illness
2023
Robust associations between white matter microstructure and general intelligence.
Stammen C, Fraenz C, Grazioplene R, Schlüter C, Merhof V, Johnson W, Güntürkün O, DeYoung C, Genç E. Robust associations between white matter microstructure and general intelligence. Cerebral Cortex 2023, 33: 6723-6741. PMID: 36682883, DOI: 10.1093/cercor/bhac538.Peer-Reviewed Original ResearchConceptsInformation processingSpecific fiber bundlesFast information processingParallel information processingMixed observationsFiber orientation distributionIntegration theoryOrientation distributionStatistics studyData setsInformation transferSpatial statistics studyAnisotropyTheoryFiber bundlesExtension
2022
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructureGenerativity Among Persons Providing or Receiving Peer or Mutual Support: A Scoping Review
Jordan G, Grazioplene R, Florence A, Hammer P, Funaro MC, Davidson L, Bellamy CD. Generativity Among Persons Providing or Receiving Peer or Mutual Support: A Scoping Review. Psychiatric Rehabilitation Journal 2022, 45: 123-135. PMID: 34618488, DOI: 10.1037/prj0000498.Peer-Reviewed Original ResearchThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2020
Apophenia as the Disposition to False Positives: A Unifying Framework for Openness and Psychoticism
Blain S, Longenecker J, Grazioplene R, Klimes-Dougan B, DeYoung C. Apophenia as the Disposition to False Positives: A Unifying Framework for Openness and Psychoticism. Journal Of Psychopathology And Clinical Science 2020, 129: 279-292. PMID: 32212749, PMCID: PMC7112154, DOI: 10.1037/abn0000504.Peer-Reviewed Original ResearchConceptsPositive symptomsOpenness aspectsEmotion recognition taskTheory of mindReport indicatorsWord association taskFalse positive error rateAuditory signal detectionStructural equation modelComputerized tasksPositive schizotypyAssociation taskFalse positive errorsMental contentRecognition taskNormal personality variationDigit identificationPersonality traitsPromising constructPersonality variationPsychosis spectrumPsychoticismSample 2ApopheniaSample 1
2019
Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks
Blain S, Grazioplene R, Ma Y, DeYoung C. Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks. Schizophrenia Bulletin 2019, 46: 540-551. PMID: 31603227, PMCID: PMC7147581, DOI: 10.1093/schbul/sbz103.Peer-Reviewed Original ResearchConceptsFrontoparietal networkFunctional connectivityFunctional magnetic resonance imagingFrontoparietal control networkState functional magnetic resonance imagingIntelligenceNeural modelIntrinsic connectivity networksMeasures of psychoticismHuman Connectome ProjectStructural equation modelingNetworkCognitive controlNeural correlatesPsychosis pronenessLatter networkCognitive deficitsNetwork coherenceConnectome ProjectControl networkEquation modelingPsychosis riskConnectivityStructural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents
Delaparte L, Bartlett E, Grazioplene R, Perlman G, Gardus J, DeLorenzo C, Klein D, Kotov R. Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents. Psychophysiology 2019, 56: e13376. PMID: 30942481, PMCID: PMC6650330, DOI: 10.1111/psyp.13376.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexT1-weighted structural MRIHigher white matter integrityCritical neurodevelopmental periodMultimodal neuroimaging techniquesWhite matter integrityNeurodevelopmental periodAmygdala volumeCortical thicknessBrain regionsStructural MRIUncinate fasciculusFractional anisotropyNeuroimaging techniquesCortexAdolescent girlsStructural correlatesFemale adolescentsDiffusion tensorAmygdalaAdolescenceAssociationAdult samplesHigh neuroticism
2016
White Matter Correlates of Psychosis-Linked Traits Support Continuity Between Personality and Psychopathology
Grazioplene R, Chavez R, Rustichini A, DeYoung C. White Matter Correlates of Psychosis-Linked Traits Support Continuity Between Personality and Psychopathology. Journal Of Psychopathology And Clinical Science 2016, 125: 1135-1145. PMID: 27819473, PMCID: PMC5117638, DOI: 10.1037/abn0000176.Peer-Reviewed Original ResearchConceptsWhite matter correlatesWhite matter connectivity patternsWhite matter differencesPsychotic spectrum disordersWhite matter connectivityWhite matter microstructureGeneral populationPsychotic disordersProtective roleBrain structuresSubclinical levelsLarge community sampleNeural structuresCommunity sampleConnectivity patternsDisordersEndophenotype studiesSpectrum disorderBiological supportCorrelates
2015
Functional Coherence of Insula Networks Is Associated With Externalizing Behavior
Abram S, Wisner K, Grazioplene R, Krueger R, MacDonald A, DeYoung C. Functional Coherence of Insula Networks Is Associated With Externalizing Behavior. Journal Of Psychopathology And Clinical Science 2015, 124: 1079-1091. PMID: 26301974, PMCID: PMC4658249, DOI: 10.1037/abn0000078.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity networksGeneral disinhibitionSubstance abuseInsula networksFunctional MRI scansSubstance use problemsInsular cortexMRI scansAmygdala abnormalitiesLarge community sampleNeural synchronyDisinhibitionExternalizing behaviorsCommunity sampleAggression domainExternalizing psychopathologyRegression modelsConnectivity networksRecent studiesAbuseCommunity participantsMaladaptive behaviorsExternalizing Spectrum InventoryOpenness to Experience and Intellect Differentially Predict Creative Achievement in the Arts and Sciences
Kaufman S, Quilty L, Grazioplene R, Hirsh J, Gray J, Peterson J, DeYoung C. Openness to Experience and Intellect Differentially Predict Creative Achievement in the Arts and Sciences. Journal Of Personality 2015, 84: 248-258. PMID: 25487993, PMCID: PMC4459939, DOI: 10.1111/jopy.12156.Peer-Reviewed Original ResearchConceptsCreative achievementCognitive abilitiesDivergent thinkingGeneral cognitive abilityDual-process theoryIndependent predictive validityOpenness/IntellectCognitive engagementDiscriminant validityPredictive validityDiverse sampleCreativityScientific creativityArtSemantic informationIntellectAchievementOpennessThinkingExtraversionPerformance measuresPersonalityValidityAbilityParticipants
2014
Subcortical intelligence: Caudate volume predicts IQ in healthy adults
Grazioplene R, Ryman S, Gray J, Rustichini A, Jung R, DeYoung C. Subcortical intelligence: Caudate volume predicts IQ in healthy adults. Human Brain Mapping 2014, 36: 1407-1416. PMID: 25491047, PMCID: PMC6869035, DOI: 10.1002/hbm.22710.Peer-Reviewed Original ResearchConceptsCaudate volumeDopamine receptor availabilityHealthy adultsAttentional functionsVerbal abilityLarge independent samplesIQTotal brain volumeSubcortical structuresIndependent samplesIntelligenceBilateral caudate volumesCaudate morphologyBrain volumeReceptor availabilityPositive associationCaudate nucleusAdultsSignificant positive correlationLearningCaudatePositive correlationAssociation
2013
“They who dream by day”: Parallels between Openness to Experience and dreaming
DeYoung C, Grazioplene R. “They who dream by day”: Parallels between Openness to Experience and dreaming. Behavioral And Brain Sciences 2013, 36: 615-615. PMID: 24304755, DOI: 10.1017/s0140525x13001283.Commentaries, Editorials and Letters
2012
A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality
Grazioplene R, DeYoung C, Rogosch F, Cicchetti D. A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality. Journal Of Child Psychology And Psychiatry 2012, 54: 872-880. PMID: 23240931, PMCID: PMC3608843, DOI: 10.1111/jcpp.12031.Peer-Reviewed Original Research
2010
Neuroimaging creativity: A psychometric view
Arden R, Chavez R, Grazioplene R, Jung R. Neuroimaging creativity: A psychometric view. Behavioural Brain Research 2010, 214: 143-156. PMID: 20488210, DOI: 10.1016/j.bbr.2010.05.015.Peer-Reviewed Original ResearchConceptsCreative cognitionCreativity researchBrain-imaging studiesPsychometric viewBehavioral measuresCognitionDifferent findingsLittle clear evidenceBenefit of imagingCreativityTest diversityDifferent testsSpatial localizationResearchMeasuresClear evidenceBrainConfidenceFindingsSuggestionsStudy designStudyCortical Thickness and Subcortical Gray Matter Reductions in Neuropsychiatric Systemic Lupus Erythematosus
Jung R, Segall J, Grazioplene R, Qualls C, Sibbitt W, Roldan C. Cortical Thickness and Subcortical Gray Matter Reductions in Neuropsychiatric Systemic Lupus Erythematosus. PLOS ONE 2010, 5: e9302. PMID: 20352085, PMCID: PMC2844408, DOI: 10.1371/journal.pone.0009302.Peer-Reviewed Original ResearchConceptsNeuropsychiatric systemic lupus erythematosusSystemic lupus erythematosusNPSLE groupSLE patientsGray matter volumeCortical thicknessLupus erythematosusNeuropsychiatric symptomsMatter volumeCentral nervous system involvementSystemic lupus erythematosus patientsFreeSurfer image analysis suiteLupus erythematosus patientsNervous system involvementSubcortical gray matter volumesGray matter reductionsGroup differencesSubcortical gray matter structuresSubcortical structure volumesRegional gray matter volumeGray matter structuresSLE groupCortical atrophyCortical thinningControl subjectsWhite Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging
Jung R, Grazioplene R, Caprihan A, Chavez R, Haier R. White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging. PLOS ONE 2010, 5: e9818. PMID: 20339554, PMCID: PMC2842439, DOI: 10.1371/journal.pone.0009818.Peer-Reviewed Original ResearchConceptsInferior frontal white matterFrontal white matterWhite matter integrityDiffusion tensor imagingFractional anisotropyWhite matterTensor imagingFronto-striatal circuitsFrontal lobe areasYoung adult subjectsSignificant inverse relationshipCortical thicknessNormal subjectsProjection zonesAssociation fibersAdult subjectsBrain regionsWhite matter architectureInverse correlationTesla scannerMetabolite concentrationsLobe areasComposite measurePsychopathologyInverse relationship