2022
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructure
2019
Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents
Delaparte L, Bartlett E, Grazioplene R, Perlman G, Gardus J, DeLorenzo C, Klein D, Kotov R. Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents. Psychophysiology 2019, 56: e13376. PMID: 30942481, PMCID: PMC6650330, DOI: 10.1111/psyp.13376.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexT1-weighted structural MRIHigher white matter integrityCritical neurodevelopmental periodMultimodal neuroimaging techniquesWhite matter integrityNeurodevelopmental periodAmygdala volumeCortical thicknessBrain regionsStructural MRIUncinate fasciculusFractional anisotropyNeuroimaging techniquesCortexAdolescent girlsStructural correlatesFemale adolescentsDiffusion tensorAmygdalaAdolescenceAssociationAdult samplesHigh neuroticism
2010
White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging
Jung R, Grazioplene R, Caprihan A, Chavez R, Haier R. White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging. PLOS ONE 2010, 5: e9818. PMID: 20339554, PMCID: PMC2842439, DOI: 10.1371/journal.pone.0009818.Peer-Reviewed Original ResearchConceptsInferior frontal white matterFrontal white matterWhite matter integrityDiffusion tensor imagingFractional anisotropyWhite matterTensor imagingFronto-striatal circuitsFrontal lobe areasYoung adult subjectsSignificant inverse relationshipCortical thicknessNormal subjectsProjection zonesAssociation fibersAdult subjectsBrain regionsWhite matter architectureInverse correlationTesla scannerMetabolite concentrationsLobe areasComposite measurePsychopathologyInverse relationship