1998
Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos
Gruber P, Kubalak S, Chien K. Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Development 1998, 125: 4427-4438. PMID: 9778502, DOI: 10.1242/dev.125.22.4427.Peer-Reviewed Original ResearchConceptsCardiac chamber morphogenesisChamber morphogenesisMurine embryosChamber specificationMLC-2aOnset of cardiogenesisVentricular chamber maturationMuscle cell lineageWild-type embryosVentricular chamber morphogenesisWild-type backgroundMuscle cellsAtrial markersCritical signaling eventDistinct tissue typesChamber maturationMyosin light chain 2Ventricular muscle cellsVertebrate cardiogenesisLight chain 2Signaling eventsAtrial myosin light chain 2Mechanistic dissectionAlpha-myosin heavy chainCell lineages
1997
Developmental expression of the murine spliceosome‐associated protein mSAP49
Ruiz‐Lozano P, Doevendans P, Brown A, Gruber P, Chien K. Developmental expression of the murine spliceosome‐associated protein mSAP49. Developmental Dynamics 1997, 208: 482-490. PMID: 9097020, DOI: 10.1002/(sici)1097-0177(199704)208:4<482::aid-aja4>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsRNA recognition motifTissue-specific splicingBasic C-terminusAmino acid sequencePeak of expressionHuman spliceosomeSpliceosome componentsSitu hybridization analysisMouse homologueRecognition motifRNA stabilizationAcid sequenceCardiac developmentC-terminusMouse embryosN-terminusNorthern analysisEmbryonic tissuesDevelopmental expressionHybridization analysisDay 11.5Optic vesicleMRNA distributionDay 13.5Spliceosome
1996
The molecular genetics of retinoic acid receptors: cardiovascular and limb development.
Sucov H, Lou J, Gruber P, Kubalak S, Dyson E, Gumeringer C, Lee R, Moles S, Chien K, Giguere V, Evans R. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. Biochemical Society Symposia 1996, 62: 143-56. PMID: 8971347.Peer-Reviewed Original Research