2020
Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma
Bilecz A, Stockhammer P, Theegarten D, Kern I, Jakopovic M, Samarzija M, Klikovits T, Hoda MA, Döme B, Oberndorfer F, Muellauer L, Fillinger J, Kovács I, Pirker C, Schuler M, Plönes T, Aigner C, Klepetko W, Berger W, Brcic L, Laszlo V, Hegedus B. Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma. Histopathology 2020, 77: 55-66. PMID: 32170970, DOI: 10.1111/his.14105.Peer-Reviewed Original ResearchConceptsMalignant pleural mesotheliomaEpithelioid malignant pleural mesotheliomaOverall survivalHistological subtypesPleural mesotheliomaIntensive multimodal treatment approachesEpithelioid pleural mesotheliomaIndependent prognostic factorShorter overall survivalHigh nuclear gradeMultimodal treatment approachCancer Genome Atlas (TCGA) databaseNuclear grading systemLonger OSPrognostic factorsPrognostic impactPrognostic roleRare malignancyDismal prognosisTrabecular variantMultimodal treatmentPrognostic significancePatient cohortHistopathologic parametersMultimodal therapyTumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition
Ghanim B, Rosenmayr A, Stockhammer P, Vogl M, Celik A, Bas A, Kurul IC, Akyurek N, Varga A, Plönes T, Bankfalvi A, Hager T, Schuler M, Hackner K, Errhalt P, Scheed A, Seebacher G, Hegedus B, Stubenberger E, Aigner C. Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition. Scientific Reports 2020, 10: 5784. PMID: 32238865, PMCID: PMC7113285, DOI: 10.1038/s41598-020-62813-2.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitionC-reactive proteinMalignant pleural effusionKi-67 indexPD-L1Overall survivalPleural effusionPrognostic powerPD-L1 tumor proportion scoreNegative PD-L1 statusPD-L1 positive tumorsLonger median OSMedian overall survivalPD-L1 expressionPD-L1 statusTumor proportion scoreFurther prospective validationVariety of malignanciesICI therapyMedian OSSignificant prognosticatorShorter OSIndependent prognosticatorPrognostic roleDismal prognosis
2019
Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma
Stockhammer P, Ploenes T, Theegarten D, Schuler M, Maier S, Aigner C, Hegedus B. Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma. Lung Cancer 2019, 139: 124-132. PMID: 31778960, DOI: 10.1016/j.lungcan.2019.11.013.Peer-Reviewed Original ResearchConceptsMalignant pleural mesotheliomaNon-malignant pleural diseasePleural effusionMPM patientsPleural mesotheliomaPrognostic stratificationNon-epithelioid malignant pleural mesotheliomaStage IV lung cancerEpithelioid malignant pleural mesotheliomaInferior overall survivalTGF-β levelsLevels of TGFLung cancer patientsChest CT scanOverall survivalSMRP levelsClinicopathological characteristicsDismal prognosisPleural diseaseTumor loadAggressive malignancyDisease stageCancer patientsLung cancerPrimary diagnosis1849P Pleural effusion TGF-beta is highly diagnostic and prognostic in malignant pleural mesothelioma
Stockhammer P, Ploenes T, Schuler M, Langer S, Aigner C, Hegedus B. 1849P Pleural effusion TGF-beta is highly diagnostic and prognostic in malignant pleural mesothelioma. Annals Of Oncology 2019, 30: v750-v751. DOI: 10.1093/annonc/mdz266.008.Peer-Reviewed Original ResearchMalignant pleural mesotheliomaNon-malignant pleural diseaseTGF-β levelsMPM patientsPleural mesotheliomaNon-epithelioid malignant pleural mesotheliomaMultivariate Cox regression modelWorse overall survivalCox regression modelFuture clinical trialsPleural effusion samplesAdvanced diseaseMultimodality treatmentOverall survivalDismal prognosisEpithelioid tumorsPleural effusionPleural diseaseAggressive malignancyClinical trialsPrognostic biomarkerPatientsReliable biomarkersEffusion samplesSignificant negative correlation