2021
Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*
Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChildChild, PreschoolGuideline AdherenceHumansProspective StudiesRespiration, ArtificialUnited StatesVentilators, MechanicalConceptsVentilator-associated infectionPositive respiratory culturesRespiratory culturesAntibiotic continuationPhase 3 subjectsRespiratory culture resultsVentilator-Associated InfectionsObservational cohort studyOverall study populationBaseline data collectionPhase 1Antibiotic discontinuationAntibiotic recommendationsAntibiotic guidelinesAntibiotic decisionsCohort studyGuideline adherenceMicrobiologic dataIllness severityMechanical ventilationAntibiotic managementRespiratory secretionsAntibiotic utilizationConsensus guidelinesAntibiotic treatment
2020
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenQuality of evidenceManagement of infectionsEvidence-based recommendationsGuideline development processResuscitation of childrenInternational expertsRecommendations AssessmentAdjunctive therapyMetabolic therapyPractice patternsConsistent careLarge cohortPanel membersResearch prioritiesSystematic reviewInternational guidelinesDysfunction
2019
Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.
Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPhase 1 dataAntibiotic guidelinesGuideline scoreAntibiotic usePediatric Logistic Organ Dysfunction-2 scoreDuration of antibioticsPICU-free daysVentilator-Associated InfectionsVentilator-free daysInitiation of antibioticsProspective data collectionPhase 3Median ageMechanical ventilationVentilated childrenScore 3Consensus conferenceClinical testingScoring systemInfectionLiterature searchExpert panelAntibioticsScores