2001
Accelerated age-related CpG island methylation in ulcerative colitis.
Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Research 2001, 61: 3573-7. PMID: 11325821.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAge FactorsAgedCarrier ProteinsChondroitin Sulfate ProteoglycansColitis, UlcerativeColonic NeoplasmsCpG IslandsDNA MethylationGenes, p16HumansIntestinal MucosaLectins, C-TypeMiddle AgedMutL Protein Homolog 1MyoD ProteinNeoplasm ProteinsNuclear ProteinsPrecancerous ConditionsReceptors, EstrogenVersicansConceptsMechanism of geneP16 exon 1Exon 1CpG island hypermethylationCpG island methylationMethylation marksMethylation patternsUndesirable genesColorectal epithelial cellsIsland hypermethylationIsland methylationGenesMethylationPremature agingMyoDColon cancerHigh-grade dysplasiaEpithelial cellsCell turnoverHypermethylationNon-UC controlsNormal appearing epitheliumUlcerative colitisHigh levelsCSPG2
1999
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
Toyota M, Ho C, Ahuja N, Jair KW, Li Q, Ohe-Toyota M, Baylin SB, Issa JP. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Research 1999, 59: 2307-12. PMID: 10344734.Peer-Reviewed Original Research5-MethylcytosineAdenocarcinomaChondroitin Sulfate ProteoglycansCloning, MolecularColorectal NeoplasmsCpG IslandsCytosineDNA MethylationDNA, NeoplasmDNA, RibosomalDNA-Binding ProteinsExonsEye ProteinsGenes, p16Homeobox Protein Nkx-2.5Homeodomain ProteinsHumansLectins, C-TypePaired Box Transcription FactorsPAX6 Transcription FactorPolymerase Chain ReactionRepressor ProteinsRNA, RibosomalSubtraction TechniqueTranscription FactorsTubulinVersicans