2015
Patients need safer hospitals, every day of the week
Dharmarajan K, Kim N, Krumholz HM. Patients need safer hospitals, every day of the week. The BMJ 2015, 350: h1826. PMID: 25877669, DOI: 10.1136/bmj.h1826.Peer-Reviewed Original ResearchIntravenous Fluids in Acute Decompensated Heart Failure
Bikdeli B, Strait KM, Dharmarajan K, Li SX, Mody P, Partovian C, Coca SG, Kim N, Horwitz LI, Testani JM, Krumholz HM. Intravenous Fluids in Acute Decompensated Heart Failure. JACC Heart Failure 2015, 3: 127-133. PMID: 25660836, PMCID: PMC4438991, DOI: 10.1016/j.jchf.2014.09.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCohort StudiesDatabases, FactualFemaleFluid TherapyHeart FailureHospital MortalityHospitalizationHumansInfusions, IntravenousIntensive Care UnitsIntubation, IntratrachealIsotonic SolutionsMaleMiddle AgedRenal Replacement TherapyRetrospective StudiesRinger's SolutionSaline Solution, HypertonicSodium Potassium Chloride Symporter InhibitorsUnited StatesYoung AdultConceptsAcute decompensated heart failureDecompensated heart failureHeart failureIntravenous fluidsRetrospective cohort studyCritical care admissionRenal replacement therapyDays of hospitalizationProportion of hospitalizationsHalf-normal salineWarrants further investigationOnly diureticsCare admissionHospital deathHospital outcomesCohort studyLoop diureticsPatient groupReplacement therapyWorse outcomesNormal salineInpatient careMedian volumePatientsHospitalization
2014
Trends in Aortic Dissection Hospitalizations, Interventions, and Outcomes Among Medicare Beneficiaries in the United States, 2000–2011
Mody PS, Wang Y, Geirsson A, Kim N, Desai MM, Gupta A, Dodson JA, Krumholz HM. Trends in Aortic Dissection Hospitalizations, Interventions, and Outcomes Among Medicare Beneficiaries in the United States, 2000–2011. Circulation Cardiovascular Quality And Outcomes 2014, 7: 920-928. PMID: 25336626, PMCID: PMC4380171, DOI: 10.1161/circoutcomes.114.001140.Peer-Reviewed Original Research
2013
HOSPITAL PRACTICE PATTERNS IN NONINVASIVE POSITIVE PRESSURE VENTILATION USE AMONG PATIENTS WITH ACUTE HEART FAILURE
Kulkarni V, Kim N, Dai Y, Dharmarajan K, Bikdeli B, Safavi K, Krumholz H. HOSPITAL PRACTICE PATTERNS IN NONINVASIVE POSITIVE PRESSURE VENTILATION USE AMONG PATIENTS WITH ACUTE HEART FAILURE. Journal Of The American College Of Cardiology 2013, 61: e1544. DOI: 10.1016/s0735-1097(13)61544-2.Peer-Reviewed Original Research
2012
Procedure Intensity and the Cost of Care
Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure Intensity and the Cost of Care. Circulation Cardiovascular Quality And Outcomes 2012, 5: 308-313. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/circoutcomes.112.966069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCosts and Cost AnalysisCross-Sectional StudiesFemaleHeart FailureHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHospitals, RuralHospitals, TeachingHospitals, UrbanHumansLength of StayLinear ModelsMaleMiddle AgedModels, EconomicOutcome and Process Assessment, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHF hospitalizationHeart failureInvasive proceduresHospital groupRisk-standardized mortality ratesProportion of patientsLength of stayCost of careWilcoxon rank sum testHigher procedure ratesRank sum testPatient demographicsPerspective databaseMedian lengthSurgical proceduresProcedure ratesHospitalizationOutcome differencesMortality rateHospitalPatientsPractice styleProcedure useSum testOverall useWIDE VARIATION EXISTS IN RATES OF ADMISSION TO INTENSIVE CARE UNITS FOR HEART FAILURE PATIENTS ACROSS US HOSPITALS
Safavi K, Dharmarajan K, Kim N, Strait K, Li S, Chen S, Lagu T, Partovian C, Krumholz H. WIDE VARIATION EXISTS IN RATES OF ADMISSION TO INTENSIVE CARE UNITS FOR HEART FAILURE PATIENTS ACROSS US HOSPITALS. Journal Of The American College Of Cardiology 2012, 59: e1856. DOI: 10.1016/s0735-1097(12)61857-9.Peer-Reviewed Original Research
2010
Refill Adherence to Oral Hypoglycemic Agents and Glycemic Control in Veterans
Kim N, Agostini JV, Justice AC. Refill Adherence to Oral Hypoglycemic Agents and Glycemic Control in Veterans. Annals Of Pharmacotherapy 2010, 44: 800-808. PMID: 20388863, PMCID: PMC3117591, DOI: 10.1345/aph.1m570.Peer-Reviewed Original ResearchConceptsOral hypoglycemic agentsGlycemic controlGoal A1CHypoglycemic agentsBaseline dateInadequate diabetes controlPercent of patientsPoor glycemic controlMain outcome measuresBaseline A1CContinuous refillNonpersistent patientsComorbid hypertensionDiabetes medicationsMedian ageBetter persistenceMedication nonadherenceDiabetes controlDays' supplyOutcome measuresClinical careEligible veteransPatientsA1CMedicationsEvaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value?
Braithwaite RS, Fiellin DA, Nucifora K, Bryant K, Roberts M, Kim N, Justice AC. Evaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value? Value In Health 2010, 13: 535-542. PMID: 20345544, PMCID: PMC3032536, DOI: 10.1111/j.1524-4733.2010.00714.x.Peer-Reviewed Original ResearchConceptsAbsolute risk reductionNonadherent patientsAdherence interventionsRelative riskRisk factorsAntiretroviral therapy adherence interventionsEffect sizeNonadherence risk factorsBehavioral risk factorsHIV careAntiretroviral adherencePatientsNonadherenceSocietal perspectiveIncremental costIntervention costsSmall effect sizesLife expectancyInterventionRisk reductionPlausible effect sizes
2009
Measuring Persistence to Oral Hypoglycemic Agents in Type 2 Diabetic Veterans
Kim N, Agostini J, Justice A. Measuring Persistence to Oral Hypoglycemic Agents in Type 2 Diabetic Veterans. Journal Of Pharmacy Technology 2009, 25: 223-229. PMID: 21779543, PMCID: PMC3139220, DOI: 10.1177/875512250902500402.Peer-Reviewed Original ResearchOral hypoglycemic agentsHypoglycemic agentsDiabetic veteransTotal daysStudy entryMedian persistenceKappa agreement statisticsContinuous refillMultiple comorbiditiesMost patientsMedian ageDiabetes controlMedication adherenceInclusion criteriaEligible veteransPoor persistenceSubstantial proportionClinical applicationVeteransPatientsFirst yearAgreement statisticsDaysPrescriptionContinuous fill
2006
Challenges in ambulatory resident education: medication knowledge in disadvantaged patients.
Kim N, Talwalkar J, Holmboe E. Challenges in ambulatory resident education: medication knowledge in disadvantaged patients. Connecticut Medicine 2006, 70: 549-57. PMID: 17131901.Peer-Reviewed Original ResearchConceptsMedication knowledgePatients' medication knowledgeSide effectsMedication namesPoor medication knowledgeLow-income patientsCross-sectional studyDiscrepant medicationsResident providersClinic visitsMost patientsDisadvantaged patientsMedication adherenceMedication mismanagementSame clinicTherapeutic failureChronic conditionsChronic diseasesTreatment goalsMedication informationClinic accessPatientsMedicationsTeaching clinicPatient safety