Featured Publications
Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides
Sawano M, Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Kohno T, Anzai T, Fukuda K, Yoshikawa T. Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides. ESC Heart Failure 2018, 5: 610-619. PMID: 29520978, PMCID: PMC6073038, DOI: 10.1002/ehf2.12278.Peer-Reviewed Original ResearchConceptsMAGGIC scoreBNP levelsB-type natriuretic peptide levelsAcute Heart Failure registryChronic Heart Failure (MAGGIC) scoreConsecutive acute HF patientsHeart failure patient outcomesHeart Failure Risk ScoreMeta-Analysis Global GroupAcute HF patientsHeart Failure RegistryHeart failure scoreProspective multicentre registryIncremental prognostic valueNatriuretic peptide levelsHeart failure patientsMulticentre registryHF patientsFailure patientsYear mortalityNatriuretic peptidePatient mortalityPrognostic valueMean ageJapanese Registry
2024
Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records
Brush J, Lu Y, Liu Y, Asher J, Li S, Sawano M, Young P, Schulz W, Anderson M, Burrows J, Krumholz H. Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records. Journal Of The American Heart Association 2024, 13: e033253. PMID: 38686864, PMCID: PMC11179912, DOI: 10.1161/jaha.123.033253.Peer-Reviewed Original ResearchConceptsElectronic health recordsRegional health systemImprove hypertension careHealth systemHealth recordsHypertension careDiastolic blood pressureAge-adjusted prevalence ratesNon-Hispanic Black patientsPrevalence ratesLarger health systemCross-sectional analysisTransformation of medical dataLeveraging real-world dataHigh prevalence rateHypertension trendsHypertension prevalenceBlood pressureBlood pressure measurementsHypertension diagnosisPrimary outcomeNational trendsProportion of patientsAntihypertensive medicationsBlack patients
2020
Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial
Sawano M, Katsuki T, Kitai T, Tamita K, Obunai K, Ikegami Y, Yamane T, Ueda I, Endo A, Maekawa Y, Kawamura A, Fukuda K, Kohsaka S. Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial. Open Heart 2020, 7: e001406. PMID: 33087441, PMCID: PMC7580072, DOI: 10.1136/openhrt-2020-001406.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngina PectorisCalcium Channel BlockersCoronary Artery DiseaseCoronary VasospasmDrug-Eluting StentsFemaleHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsMajor cardiovascular eventsPercutaneous coronary interventionCalcium channel blockersCoronary artery diseaseStable coronary artery diseaseDrug-eluting stent implantationAcetylcholine provocation testingDiagnostic coronary angiographyBeta blockersCCB groupArtery diseaseCoronary angiographyVasospastic anginaCoronary revascularisationProvocation testingStent implantationChannel blockersSecond-generation drug-eluting stent implantationUniversity Hospital Medical Information Network Clinical Trials RegistryIndex percutaneous coronary interventionNon-fatal myocardial infarctionSingle-vessel lesionsSubsequent coronary eventsCoronary artery spasmClinical Trials Registry
2019
Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion
2018
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Shoji S, Kohsaka S, Kumamaru H, Sawano M, Shiraishi Y, Ueda I, Noma S, Suzuki M, Numasawa Y, Hayashida K, Yuasa S, Miyata H, Fukuda K. Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention. Circulation Cardiovascular Interventions 2018, 11: e006761. PMID: 30545258, DOI: 10.1161/circinterventions.118.006761.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPeriprocedural strokeTransradial interventionTransfemoral interventionCoronary interventionAccess siteElective percutaneous coronary interventionPropensity score-matched analysisMultivariable logistic regression analysisOptimal access siteProspective multicenter databaseAcute kidney injuryAcute coronary syndromeChronic kidney diseaseLife-threatening complicationsPeripheral artery diseaseLogistic regression analysisCoronary syndromeHemorrhagic eventsKidney injuryPCI complicationsArtery diseaseMulticenter databaseStroke patientsKidney diseaseAn overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry
Numasawa Y, Inohara T, Ishii H, Yamaji K, Hirano K, Kohsaka S, Sawano M, Kuno T, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Investigators O. An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry. Catheterization And Cardiovascular Interventions 2018, 94: e1-e8. PMID: 30467967, DOI: 10.1002/ccd.27986.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionJapanese nationwide registryDialysis patientsHospital mortalityNondialysis patientsCoronary interventionNationwide registryACS cohortHeart failureAdverse outcomesAcute heart failureMore comorbiditiesCardiogenic shockHospital outcomesBlood transfusionClinical trialsFemale genderPCI casesPatientsJapanese hospitalsGreater riskMortalityComplicationsRegistryRisk
2017
Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry
Inohara T, Kohsaka S, Miyata H, Sawano M, Ueda I, Maekawa Y, Fukuda K, Jones PG, Cohen DJ, Zhao Z, Spertus JA, Smolderen KG. Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry. Journal Of The American Heart Association 2017, 6: e006529. PMID: 29079567, PMCID: PMC5721753, DOI: 10.1161/jaha.117.006529.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableChi-Square DistributionFemaleHospitals, TeachingHumansIncidenceJapanLogistic ModelsMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreProportional Hazards ModelsRegistriesRetreatmentRisk FactorsTime FactorsTreatment OutcomeConceptsSubsequent acute coronary syndromeAcute coronary syndromePercutaneous coronary interventionPropensity-matched cohortUnplanned coronary revascularizationIndex percutaneous coronary interventionComposite end pointUnplanned revascularizationCoronary revascularizationCoronary syndromeCoronary interventionUnstable anginaClinical trialsEnd pointJapanese multicenter registryLong-term mortalityAcute myocardial infarctionRisk of mortalityProportional hazards modelLong-term survivalJapanese teaching hospitalsCause mortalityMulticenter registryPCI patientsSubsequent survivalBarriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice
Ikemura N, Sawano M, Shiraishi Y, Ueda I, Miyata H, Numasawa Y, Noma S, Suzuki M, Momiyama Y, Inohara T, Hayashida K, Yuasa S, Maekawa Y, Fukuda K, Kohsaka S. Barriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice. Circulation Journal 2017, 81: cj-16-0905. PMID: 28228609, DOI: 10.1253/circj.cj-16-0905.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionDTB timeSTEMI patientsMedian DTB timeProspective multicenter databaseShorter DTB timeUse of IABPPeripheral artery diseaseLow-volume institutionsPrior revascularizationVA-ECMOMultiple comorbiditiesPrimary PCIBalloon timeSymptom onsetArtery diseaseHeart failureIndependent predictorsMulticenter databaseBalloon delayMyocardial infarctionPatientsStudy periodTime trendsImportant quality indicator
2015
Effect of Estimated Plasma Volume Reduction on Renal Function for Acute Heart Failure Differs Between Patients With Preserved and Reduced Ejection Fraction
Takei M, Kohsaka S, Shiraishi Y, Goda A, Izumi Y, Yagawa M, Mizuno A, Sawano M, Inohara T, Kohno T, Fukuda K, Yoshikawa T. Effect of Estimated Plasma Volume Reduction on Renal Function for Acute Heart Failure Differs Between Patients With Preserved and Reduced Ejection Fraction. Circulation Heart Failure 2015, 8: 527-532. PMID: 25737498, DOI: 10.1161/circheartfailure.114.001734.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdministration, IntravenousAgedAged, 80 and overChi-Square DistributionDisease ProgressionDiuresisDiureticsFemaleHeart FailureHumansIdeal Body WeightKidneyLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPlasma VolumeRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsStroke VolumeTime FactorsTokyoTreatment OutcomeVentricular Function, LeftConceptsPlasma volume reductionAcute heart failureHeart failureRenal functionEjection fractionBody weightWest Tokyo Heart Failure registryAcute heart failure patientsReduced ejection fraction cohortReduced ejection fraction groupEjection fraction groupHeart Failure RegistryReduced ejection fractionHistory of hypertensionGlomerular filtration rateHeart failure patientsIdeal body weightSubject's body weightVolume reductionHFpEF cohortIntravenous diureticsFailure patientsHemodynamic effectsDiabetes mellitusKidney function