Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese populationSex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomes
2023
Transradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study
Kuno T, Yamaji K, Aikawa T, Sawano M, Ando T, Numasawa Y, Wada H, Amano T, Kozuma K, Kohsaka S. Transradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study. European Heart Journal Open 2023, 3: oead116. PMID: 38105921, PMCID: PMC10721448, DOI: 10.1093/ehjopen/oead116.Peer-Reviewed Original ResearchPercutaneous coronary interventionAccess site bleedingTransradial interventionHospital deathTransfemoral interventionPeriprocedural complicationsSite bleedingCoronary interventionDialysis patientsAccess siteLower riskNationwide registry studyChronic coronary syndromeHospital complicationsCoronary syndromeRegistry studySecondary outcomesPrimary outcomePatient populationBleeding rateRegistry dataComplicationsPatientsTRI groupDialysisIschemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry)
Tobe A, Sawano M, Kohsaka S, Ishii H, Tanaka A, Numasawa Y, Amano T, Nakamura M, Ikari Y, Murohara T. Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry). The American Journal Of Cardiology 2023, 195: 37-44. PMID: 37004333, DOI: 10.1016/j.amjcard.2023.02.027.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionPresence of CKDCKD stages 1Ischemic eventsAdjustment of covariatesHigh riskPCI registryCoronary interventionKidney diseaseNew-generation drug-eluting stent implantationDrug-eluting stent implantationUnderwent Percutaneous Coronary InterventionCKD stage 3Stage 1Bleeding eventsBleeding outcomesDialysis groupOral anticoagulantsCKD 3Renal functionStent implantationIncidence ratePatientsCare deliveryGenetic Backgrounds Associated With Stent Thrombosis A Pilot Study From a Percutaneous Coronary Intervention Registry
Shoji S, Sawano M, Inohara T, Hiraide T, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Genetic Backgrounds Associated With Stent Thrombosis A Pilot Study From a Percutaneous Coronary Intervention Registry. JACC Advances 2023, 2: 100172. PMID: 38939036, PMCID: PMC11198226, DOI: 10.1016/j.jacadv.2022.100172.Peer-Reviewed Original ResearchEarly stent thrombosisLST/VLSTPercutaneous coronary interventionStent thrombosisPolygenic risk scoresCoronary interventionMulticenter PCI registryLate stent thrombosisA Pilot StudyDifferent genetic predispositionPCI patientsPCI registrySignificant single nucleotide polymorphismsPathophysiologic characteristicsPatient populationFatal eventsRisk scoreGenetic predispositionVLSTThrombosisPatientsPilot studyRegistryRisk predictionSingle nucleotide polymorphisms
2022
Machine learning models for prediction of adverse events after percutaneous coronary intervention
Niimi N, Shiraishi Y, Sawano M, Ikemura N, Inohara T, Ueda I, Fukuda K, Kohsaka S. Machine learning models for prediction of adverse events after percutaneous coronary intervention. Scientific Reports 2022, 12: 6262. PMID: 35428765, PMCID: PMC9012739, DOI: 10.1038/s41598-022-10346-1.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse eventsRisk scoreHospital mortalityCoronary interventionConsecutive coronary artery disease patientsCoronary artery disease patientsAdverse periprocedural eventsLow-risk patientsMajor adverse eventsGood discriminationMulticenter registryPeriprocedural eventsDisease patientsClinical decisionLogistic regressionSpecific interventionsRisk predictionOverall risk predictionPatientsScoresInterventionMortalityAdequate discriminationOutcomes
2021
Successful Conservative Treatment of Cardiac Rupture Associated with Takotsubo Syndrome
Mano Y, Baba A, Sukegawa H, Sawano M, Nishiyama T, Ohki T. Successful Conservative Treatment of Cardiac Rupture Associated with Takotsubo Syndrome. Internal Medicine 2021, 60: 2097-2102. PMID: 33551402, PMCID: PMC8313900, DOI: 10.2169/internalmedicine.5831-20.Peer-Reviewed Case Reports and Technical NotesConceptsTakotsubo syndromeCardiac ruptureLeft ventricular outflow tract obstructionVentricular outflow tract obstructionProphylactic anticoagulation therapyOutflow tract obstructionSuccessful conservative treatmentAnticoagulation therapyTract obstructionApical thrombusConservative treatmentCardiac surgeryHemoglobin levelsCareful observationPatientsSyndromeTreatmentRuptureHemopericardiumSurgeryAdmissionThrombusObstructionTherapyWeeks
2020
Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study
Kuno T, Numasawa Y, Mikami T, Niimi N, Sawano M, Kodaira M, Suzuki M, Ueno K, Ueda I, Fukuda K, Kohsaka S. Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study. Heart And Vessels 2020, 36: 330-336. PMID: 33034713, DOI: 10.1007/s00380-020-01706-w.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionRisk of AKIHemoglobin dropAKI incidenceKidney injuryCoronary interventionHemoglobin levelsProspective multi-center studySerum creatinine levelsMulti-center studyRelative decreaseConsecutive patientsCreatinine levelsIndependent predictorsRisk factorsHemoglobin changeHigh riskAbsolute decreaseLogistic regressionPatientsIncidenceHemoglobinInjuryDlAssociation of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease
Ejiri K, Sawano M, Numasawa Y, Noma S, Ito H, Fukuda K, Kohsaka S. Association of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease. JAMA Network Open 2020, 3: e2012546. PMID: 32756926, PMCID: PMC7407091, DOI: 10.1001/jamanetworkopen.2020.12546.Peer-Reviewed Original ResearchAdherence to antihypertensive medication and its predictors among non-elderly adults in Japan
Nishimura S, Kumamaru H, Shoji S, Sawano M, Kohsaka S, Miyata H. Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan. Hypertension Research 2020, 43: 705-714. PMID: 32313192, DOI: 10.1038/s41440-020-0440-2.Peer-Reviewed Original ResearchConceptsLow adherenceAntihypertensive medicationsAntihypertensive drugsJapanese patientsLarge administrative claims databaseAntihypertensive drug usersInitiation of angiotensinAdministrative claims databaseSuboptimal clinical outcomesProportion of daysNon-elderly adultsLogistic regression analysisHypertensive patientsThiazide diureticsClinical outcomesClaims databaseFemale sexHigh adherencePatientsEnzyme inhibitorsDrug usersYounger ageTargeted interventionsFacility characteristicsLarge hospitalsPrediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model.
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas T, Levy W, Yoshikawa T. Prediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model. EP Europace 2020, 22: 588-597. PMID: 32155253, DOI: 10.1093/europace/euaa002.Peer-Reviewed Original ResearchConceptsSeattle Proportional Risk ModelSudden cardiac deathHF patientsProportional risk modelCardiac deathHeart failureIncidence of SCDJapanese heart failure patientsAcute HF patientsICD eligibility criteriaReduced ejection fractionHeart failure patientsHosmer-Lemeshow statisticHF registryAcute decompensationCumulative incidenceFailure patientsEjection fractionC-statisticJapanese RegistryJapanese patientsC-indexSCD predictionEligibility criteriaPatients
2019
Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatients
2018
An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry
Numasawa Y, Inohara T, Ishii H, Yamaji K, Hirano K, Kohsaka S, Sawano M, Kuno T, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Investigators O. An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry. Catheterization And Cardiovascular Interventions 2018, 94: e1-e8. PMID: 30467967, DOI: 10.1002/ccd.27986.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionJapanese nationwide registryDialysis patientsHospital mortalityNondialysis patientsCoronary interventionNationwide registryACS cohortHeart failureAdverse outcomesAcute heart failureMore comorbiditiesCardiogenic shockHospital outcomesBlood transfusionClinical trialsFemale genderPCI casesPatientsJapanese hospitalsGreater riskMortalityComplicationsRegistryRiskValidation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients
Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Nagatomo Y, Sujino Y, Fukuoka R, Sawano M, Kohno T, Fukuda K, Anzai T, Shadman R, Dardas T, Levy W, Yoshikawa T. Validation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients. Journal Of Cardiac Failure 2018, 25: 561-567. PMID: 30099192, DOI: 10.1016/j.cardfail.2018.07.463.Peer-Reviewed Original ResearchConceptsSeattle Heart Failure ModelHeart failure patientsHF patientsHeart failure modelHFrEF patientsHFpEF patientsEjection fractionFailure patientsAcute heart failure patientsAcute HF patientsConventional clinical variablesJapanese HF patientsReduced ejection fractionPrecise risk stratificationAcute decompensationHeart failureHospital admissionNational CerebralRisk stratificationClinical variablesC-statisticHeart failure databaseModest discriminationPatientsMedical resourcesP5667Predicting sudden cardiac death in Japanese heart failure patients: International validation of the Seattle Proportional Risk Model
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas T, Levy W, Yoshikawa T. P5667Predicting sudden cardiac death in Japanese heart failure patients: International validation of the Seattle Proportional Risk Model. European Heart Journal 2018, 39: ehy566.p5667. DOI: 10.1093/eurheartj/ehy566.p5667.Peer-Reviewed Original ResearchAcute heart failure management in the USA and Japan: overview of practice patterns and review of evidence
Tanaka T, Sawano M, Ramani R, Friedman M, Kohsaka S. Acute heart failure management in the USA and Japan: overview of practice patterns and review of evidence. ESC Heart Failure 2018, 5: 931-947. PMID: 29932314, PMCID: PMC6165950, DOI: 10.1002/ehf2.12305.Peer-Reviewed Original ResearchConceptsAcute heart failureTreatment strategiesHeart failureClinical outcomesManagement of AHFAcute heart failure managementOngoing public health issueChronic heart failureHeart failure managementMedical treatment optionsContemporary treatment strategiesEffective treatment strategiesPublic health issueClinical symptomsTreatment optionsPractice patternsSingle agentReview of evidenceFailure managementHealth issuesDefinitive rolePatientsOutcomesFailureSymptoms
2017
Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry
Sawano M, Kohsaka S, Abe T, Inohara T, Maekawa Y, Ueda I, Sueyoshi K, Suzuki M, Noma S, Numasawa Y, Miyata H, Fukuda K, Smolderen KG, Spertus JA. Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry. PLOS ONE 2017, 12: e0182687. PMID: 28817616, PMCID: PMC5560610, DOI: 10.1371/journal.pone.0182687.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCoronary artery diseasePCI patientsStatin therapyArtery diseaseKidney diseaseHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisPercutaneous coronary intervention registryJapanese PCI registryStatin prescription patternsCoronary Intervention RegistryLow-intensity statinsLogistic regression analysisCardiovascular eventsPCI registryIntervention RegistryPatient characteristicsPrescription patternsReal-world practiceStudy registryEffective medicationsHigh riskPatientsHigher agePERFORMANCE OF THE MAGGIC HEART FAILURE RISK SCORE IN JAPANESE ACUTE HEART FAILURE PATIENTS: A REPORT FROM THE WEST TOKYO HEART FAILURE REGISTRY
Sawano M, Inohara T, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Mahara K, Fukuda K, Yoshikawa T. PERFORMANCE OF THE MAGGIC HEART FAILURE RISK SCORE IN JAPANESE ACUTE HEART FAILURE PATIENTS: A REPORT FROM THE WEST TOKYO HEART FAILURE REGISTRY. Journal Of The American College Of Cardiology 2017, 69: 947. DOI: 10.1016/s0735-1097(17)34336-x.Peer-Reviewed Original ResearchBarriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice
Ikemura N, Sawano M, Shiraishi Y, Ueda I, Miyata H, Numasawa Y, Noma S, Suzuki M, Momiyama Y, Inohara T, Hayashida K, Yuasa S, Maekawa Y, Fukuda K, Kohsaka S. Barriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice. Circulation Journal 2017, 81: cj-16-0905. PMID: 28228609, DOI: 10.1253/circj.cj-16-0905.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionDTB timeSTEMI patientsMedian DTB timeProspective multicenter databaseShorter DTB timeUse of IABPPeripheral artery diseaseLow-volume institutionsPrior revascularizationVA-ECMOMultiple comorbiditiesPrimary PCIBalloon timeSymptom onsetArtery diseaseHeart failureIndependent predictorsMulticenter databaseBalloon delayMyocardial infarctionPatientsStudy periodTime trendsImportant quality indicatorOutcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry)
Numasawa Y, Sawano M, Miyata H, Ueda I, Noma S, Suzuki M, Kuno T, Kodaira M, Maekawa Y, Fukuda K, Kohsaka S. Outcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry). The American Journal Of Cardiology 2017, 119: 1173-1178. PMID: 28236456, DOI: 10.1016/j.amjcard.2017.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedBody Mass IndexFemaleHeart ArrestHospital MortalityHumansHypothermia, InducedJapanMaleMiddle AgedMultivariate AnalysisNo-Reflow PhenomenonPercutaneous Coronary InterventionProspective StudiesRegistriesShock, CardiogenicST Elevation Myocardial InfarctionConceptsAcute coronary syndromePercutaneous coronary interventionST-elevation myocardial infarctionCardiopulmonary arrestCardiogenic shockCoronary interventionInhospital mortalityMortality rateAcute Coronary Syndrome ComplicatedPresence of CSHours of admissionHigh mortality rateInhospital outcomesCoronary syndromeUnstable anginaIndependent predictorsShock statusMyocardial infarctionPatientsMultivariate analysisOlder ageInterventionOutcomesMortalityAge