2023
Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2017
Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Shin M, Kang Y, Leng L, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex. The Journal Of Immunology 2017, 198: 210.3-210.3. DOI: 10.4049/jimmunol.198.supp.210.3.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorIL-1β productionImmune complexesIL-1βHuman monocytesNLRP3 inflammasomeProduction of MIFExogenous MIFInhibitory factorMIF gene polymorphismsSerum MIF levelsLupus-prone miceSystemic lupus erythematosusExpression of NLRP3Subsequent tissue injuryIL-1beta productionNF-kB activationCaspase-1 activationMIF antagonistMIF levelsLupus patientsLupus erythematosusNLRP3 expressionAutoantibody production
2013
Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083)
Shin M, Kang Y, Lee N, Kim S, Kang K, Lazova R, Kang I. Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083). The Journal Of Immunology 2013, 190: 127.13-127.13. DOI: 10.4049/jimmunol.190.supp.127.13.Peer-Reviewed Original ResearchIL-1β productionAnti-dsDNA antibodiesIL-1βHuman monocytesReactive oxygen speciesCell responsesIL-1β dependent mannerPro-inflammatory cytokines IL-1βPeripheral blood mononuclear cellsSelf-nuclear antigensIL-17 productionSystemic lupus erythematosusInnate immune cellsBlood mononuclear cellsPathogenesis of lupusAntibody-positive seraCytokines IL-1βLupus pathogenesisLupus patientsLupus erythematosusAutoimmune responseCutaneous lesionsMononuclear cellsImmune cellsNLRP3 inflammasome
2012
U1-snRNP activates the NLRP3 inflammasome in human monocytes (171.7)
Shin M, Kang Y, Lee N, Kang K, Lazova R, Kang I. U1-snRNP activates the NLRP3 inflammasome in human monocytes (171.7). The Journal Of Immunology 2012, 188: 171.7-171.7. DOI: 10.4049/jimmunol.188.supp.171.7.Peer-Reviewed Original ResearchSystemic lupus erythematosusIL-1β productionU1 snRNPAutoimmune diseasesIL-1βCaspase-1Human monocytesReactive oxygen speciesU1 small nuclear RNAU1 small nuclear ribonucleoproteinCytosolic protein complexesLupus erythematosusNLRP3 inflammasomeMicrobial nucleic acidsNLRP3Protein complexesNuclear RNANuclear ribonucleoproteinPre-mRNAEndogenous DNAMonocytesAntibodiesPotential roleCD14InflammasomeAltered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10)
Kang G, Kim S, Bunin V, Shin M, Lee N, Parke A, Kang I. Altered Th17 and Th1 cells responses in patients with primary Sjogren syndrome (59.10). The Journal Of Immunology 2012, 188: 59.10-59.10. DOI: 10.4049/jimmunol.188.supp.59.10.Peer-Reviewed Original ResearchPrimary Sjogren's syndromeHealthy subjectsIL-7IL-17IL-23Sjogren's syndromeIL-10IL-12Peripheral bloodIL-1βIL-6Th1 cellsTh1-polarizing cytokine IL-12Anti-inflammatory cytokine IL-10Frequencies of Th17Frequency of CD4Cytokine IL-10IL-10 productionSystemic autoimmune diseaseCytokines IL-12IL-12 productionInnate immune cellsMajor proinflammatory cytokineSupernatants of lipopolysaccharideDry mouth