1996
YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites
Myers M, Zhang Y, Aldaz G, Grammer T, Glasheen E, Yenush L, Wang L, Sun X, Blenis J, Pierce J, White M. YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites. Molecular And Cellular Biology 1996, 16: 4147-4155. PMID: 8754813, PMCID: PMC231411, DOI: 10.1128/mcb.16.8.4147.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCell DivisionCell LineDNA ReplicationEnzyme ActivationInsulinInsulin Receptor Substrate ProteinsMolecular Sequence DataMutagenesis, Site-DirectedPhosphatidylinositol 3-KinasesPhosphoproteinsPhosphotransferases (Alcohol Group Acceptor)PhosphotyrosineProtein Serine-Threonine KinasesReceptor, InsulinRecombinant ProteinsRibosomal Protein S6 KinasesSignal TransductionStructure-Activity RelationshipConceptsTyrosine phosphorylation sitesPotential tyrosine phosphorylation sitesYMXM motifsPhosphorylation sitesIRS-1SH2 proteinTyrosine phosphorylationSrc homology 2 domainIRS-1 moleculeWild-type IRS-1Insulin receptor substrate-1Mitogen-activated protein kinaseInsulin-stimulated mitogenesisReceptor substrate-1IRS proteinsProtein kinaseMitogenic signalsMitogenic responseSubstrate-1Mitogenic sensitivityInsulin signalingInsulin stimulationPhosphotidylinositolRedundant motifsProtein
1993
Pleiotropic Insulin Signals are Engaged by Multisite Phosphorylation of IRS-1
Sun X, Crimmins D, Myers M, Miralpeix M, White M. Pleiotropic Insulin Signals are Engaged by Multisite Phosphorylation of IRS-1. Molecular And Cellular Biology 1993, 13: 7418-7428. DOI: 10.1128/mcb.13.12.7418-7428.1993.Peer-Reviewed Original ResearchSrc homology 2IRS-1SH2 domainInsulin signalingPotential tyrosine phosphorylation sitesTyrosine residuesSrc homology 2 domainSrc homology 2 proteinAmino-terminal SH2 domainInsulin stimulationPhosphorylation of tyrosine residuesTyrosine phosphorylation sitesMultisite docking proteinInsulin signal transmissionInsulin receptor substrateInsulin receptor kinaseInsulin-stimulated phosphorylationDownstream regulatory elementsPurified insulin receptorYMXM motifsActivating insulin receptor kinaseDocking proteinMultisite phosphorylationPhosphorylation sitesRegulatory elements