Featured Publications
Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
Xie L, Yuan Y, Xu S, Lu S, Gu J, Wang Y, Wang Y, Zhang X, Chen S, Li J, Lu J, Sun H, Hu R, Piao H, Wang W, Wang C, Wang J, Li N, White M, Han L, Jia W, Miao J, Liu J. Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. Cell Reports 2022, 41: 111498. PMID: 36261001, PMCID: PMC10153649, DOI: 10.1016/j.celrep.2022.111498.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseFatty liver diseaseLipid metabolism diseasesLipid catabolismHepatic lipid catabolismFatty acid oxidationDetectable hepatotoxicityCopper deficiencyNAFLD developmentLiver diseaseMetabolic diseasesMetabolism diseasesNormal levelsDiseaseMitochondrial biogenesisAcid oxidationAMPK activityAMPKAblationDeficiencyCatabolismLKB1Hepatotoxicity
2010
Insulin signaling meets mitochondria in metabolism
Cheng Z, Tseng Y, White M. Insulin signaling meets mitochondria in metabolism. Trends In Endocrinology And Metabolism 2010, 21: 589-598. PMID: 20638297, PMCID: PMC3994704, DOI: 10.1016/j.tem.2010.06.005.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseSirt1/PGC1α pathwayMitochondria generateRedox regulationTyrosine phosphataseIRS-PI3KMetabolic platformMitochondrial metabolismHigh ROS levelsMitochondrial biogenesisMolecular linkMitochondrial functionInsulin receptorMetabolic homeostasisMitochondrial dysfunctionROS levelsOxygen speciesMitochondriaInsulin actionMechanistic associationRecent studiesMetabolismMetabolic diseasesBiogenesisChain integrity